Isocorydine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Isocorydine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Isocorydine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.120313
LAMA4 laminin, alpha 4 0.104791
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0888035
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0871733
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0803132
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0785353
FAM13A family with sequence similarity 13, member A 0.0707936
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0686458
CXCL8 chemokine (C-X-C motif) ligand 8 0.0633302
SLTM SAFB-like, transcription modulator 0.0632391
ATP11A ATPase, class VI, type 11A 0.0626897
THSD4 thrombospondin, type I, domain containing 4 0.0606643
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0599072
NAMPT nicotinamide phosphoribosyltransferase 0.059884
SMAD3 SMAD family member 3 0.0540539
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0519193
SAMD4A sterile alpha motif domain containing 4A 0.0502105
PM20D1 peptidase M20 domain containing 1 0.0497961
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0487563
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0476821
IGFBP3 insulin-like growth factor binding protein 3 0.047044
TMEM45B transmembrane protein 45B 0.0469429
GRB10 growth factor receptor-bound protein 10 0.0463213
ELL2 elongation factor, RNA polymerase II, 2 0.0459731
EFNA5 ephrin-A5 0.0457485
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0449095
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0436985
CES1 carboxylesterase 1 0.0435342
CEMIP cell migration inducing protein, hyaluronan binding 0.0416901
BLZF1 basic leucine zipper nuclear factor 1 0.0414111
EGR1 early growth response 1 0.0398677
BCAR3 breast cancer anti-estrogen resistance 3 0.0397859
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0377848
LAMC2 laminin, gamma 2 0.0375671
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0369434
STC1 stanniocalcin 1 0.03617
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0357452
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0353744
ARRDC3 arrestin domain containing 3 0.0352038
EXT1 exostosin glycosyltransferase 1 0.0345201
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0338499
ERRFI1 ERBB receptor feedback inhibitor 1 0.0332304
SMYD3 SET and MYND domain containing 3 0.0326531
TPM3 tropomyosin 3 0.031786
MACC1 metastasis associated in colon cancer 1 0.0317409
DOCK5 dedicator of cytokinesis 5 0.0314589
PLEC plectin 0.0307993
LPP LIM domain containing preferred translocation partner in lipoma 0.0307597
SYAP1 synapse associated protein 1 0.0307024
FOXP1 forkhead box P1 0.0302886
ZMYND8 zinc finger, MYND-type containing 8 0.0292444
LMO7 LIM domain 7 0.0290788
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0288833
RNF213 ring finger protein 213 0.026693
LGALS12 lectin, galactoside-binding, soluble, 12 0.026684
CUL4A cullin 4A 0.0261648
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0261527
MAML3 mastermind-like 3 (Drosophila) 0.0258878
RAD51B RAD51 paralog B 0.0251303
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0249292
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0248747
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0248012
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0247014
FTH1 ferritin, heavy polypeptide 1 0.0245941
ANKRD11 ankyrin repeat domain 11 0.0245599
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0243123
SIK3 SIK family kinase 3 0.0241121
MYH9 myosin, heavy chain 9, non-muscle 0.0239936
EPAS1 endothelial PAS domain protein 1 0.0239837
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0235221
RAB27B RAB27B, member RAS oncogene family 0.0232935
BMAL2 basic helix-loop-helix ARNT like 2 0.0230227
YBX3 Y box binding protein 3 0.0227177
SAMD12 sterile alpha motif domain containing 12 0.0225972
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0225418
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.022534
AREG amphiregulin 0.0221737
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0219732
XDH xanthine dehydrogenase 0.0218732
MLKL mixed lineage kinase domain-like 0.0214361
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0211389
STK24 serine/threonine kinase 24 0.021007
SQOR sulfide quinone oxidoreductase 0.0208319
ITPKC inositol-trisphosphate 3-kinase C 0.0205692
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0205214
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0204872
EMP1 epithelial membrane protein 1 0.0201913
DOCK1 dedicator of cytokinesis 1 0.0201512
STC2 stanniocalcin 2 0.0201396
TBC1D5 TBC1 domain family, member 5 0.0198378
MSN moesin 0.0197966
MCTP1 multiple C2 domains, transmembrane 1 0.0195941
IGF2 insulin-like growth factor 2 0.0194095
RPL6 ribosomal protein L6 0.0192406
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0190806
NTN4 netrin 4 0.0190181
FOSL1 FOS-like antigen 1 0.0189911
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0189248
AHNAK2 AHNAK nucleoprotein 2 0.0188245
RTN4 reticulon 4 0.0186232

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.164557
EGFR epidermal growth factor receptor -0.130234
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.113096
PTMA prothymosin, alpha -0.106421
CAV1 caveolin 1, caveolae protein, 22kDa -0.101999
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0877546
PKM pyruvate kinase, muscle -0.0845061
FTL ferritin, light polypeptide -0.0841745
ASPH aspartate beta-hydroxylase -0.0775528
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0772332
AKR1C1 aldo-keto reductase family 1, member C1 -0.0758395
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0752739
RPS24 ribosomal protein S24 -0.0718422
ACTG1 actin gamma 1 -0.069226
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0691657
RPLP1 ribosomal protein, large, P1 -0.0687022
INTS6 integrator complex subunit 6 -0.0683911
TOP1 topoisomerase (DNA) I -0.0642199
S100A10 S100 calcium binding protein A10 -0.0599908
CST3 cystatin C -0.0595208
TXNRD1 thioredoxin reductase 1 -0.0590256
HDLBP high density lipoprotein binding protein -0.0574261
TMEM165 transmembrane protein 165 -0.0505261
RPL31 ribosomal protein L31 -0.0497862
H1-0 H1.0 linker histone -0.0477466
PDLIM5 PDZ and LIM domain 5 -0.0473221
RPS25 ribosomal protein S25 -0.0471226
EIF1 eukaryotic translation initiation factor 1 -0.0470726
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0453623
BZW1 basic leucine zipper and W2 domains 1 -0.0451612
RPL34 ribosomal protein L34 -0.0445564
KRT18 keratin 18, type I -0.0439658
KRT7 keratin 7, type II -0.0436008
WASF2 WAS protein family, member 2 -0.0434364
LOC112694756 uncharaterized LOC112694756 -0.0428573
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0425833
HOMER1 homer scaffolding protein 1 -0.0425455
RPL37A ribosomal protein L37a -0.0417845
ABLIM1 actin binding LIM protein 1 -0.0390147
KMT2E lysine (K)-specific methyltransferase 2E -0.0385612
RPL35A ribosomal protein L35a -0.0373274
GNAS GNAS complex locus -0.0370441
SEC61G Sec61 gamma subunit -0.0364964
ANKRD12 ankyrin repeat domain 12 -0.0364784
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0360865
BIRC3 baculoviral IAP repeat containing 3 -0.0348721
IGFBP5 insulin-like growth factor binding protein 5 -0.0347013
RPS27A ribosomal protein S27a -0.0346803
ZC3H11A zinc finger CCCH-type containing 11A -0.0346626
AHNAK AHNAK nucleoprotein -0.0346466
RPS23 ribosomal protein S23 -0.0341392
TKT transketolase -0.0336882
PGK1 phosphoglycerate kinase 1 -0.0332875
PATJ PATJ crumbs cell polarity complex component -0.033043
RPLP0 ribosomal protein, large, P0 -0.0329972
RPL4 ribosomal protein L4 -0.0328982
BRWD1 bromodomain and WD repeat domain containing 1 -0.0321369
RPL19 ribosomal protein L19 -0.0316378
RPS6 ribosomal protein S6 -0.0310145
UBC ubiquitin C -0.0309007
RNF145 ring finger protein 145 -0.0306589
RPS3 ribosomal protein S3 -0.0305314
CAMTA1 calmodulin binding transcription activator 1 -0.0303686
IER3 immediate early response 3 -0.0303305
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0298507
RPS17 ribosomal protein S17 -0.0296676
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0295183
S100A6 S100 calcium binding protein A6 -0.0294844
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0293832
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0286991
SPDYA speedy/RINGO cell cycle regulator family member A -0.0281806
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0279413
BTG1 B-cell translocation gene 1, anti-proliferative -0.0277315
RPS4X ribosomal protein S4, X-linked -0.0276748
SRRM2 serine/arginine repetitive matrix 2 -0.0276268
USP34 ubiquitin specific peptidase 34 -0.0275084
FBXO11 F-box protein 11 -0.027471
RPL30 ribosomal protein L30 -0.0273702
NFE2L2 nuclear factor, erythroid 2-like 2 -0.027189
NDE1 nudE neurodevelopment protein 1 -0.0271457
SETD5 SET domain containing 5 -0.0271333
RPS8 ribosomal protein S8 -0.0265681
AGR2 anterior gradient 2 -0.0264954
ATF4 activating transcription factor 4 -0.0263783
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0261451
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0259844
SPIRE1 spire-type actin nucleation factor 1 -0.0259004
RPL11 ribosomal protein L11 -0.0252934
RAB1A RAB1A, member RAS oncogene family -0.0252683
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0251904
CCNI cyclin I -0.0246885
GSK3B glycogen synthase kinase 3 beta -0.0245787
DSCAM Down syndrome cell adhesion molecule -0.0245169
ADAM32 ADAM metallopeptidase domain 32 -0.0244692
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0242488
RPS14 ribosomal protein S14 -0.024196
ANKRD10 ankyrin repeat domain 10 -0.0240828
MAP7 microtubule-associated protein 7 -0.0240674
PRRC2C proline-rich coiled-coil 2C -0.0238547
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0234705