Isocorydine_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Isocorydine perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Isocorydine_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.160636
FTH1 ferritin, heavy polypeptide 1 0.150617
AKAP12 A kinase (PRKA) anchor protein 12 0.144828
IGF2 insulin-like growth factor 2 0.1411
PM20D1 peptidase M20 domain containing 1 0.136905
TPM3 tropomyosin 3 0.127436
IGFBP3 insulin-like growth factor binding protein 3 0.111086
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.10888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.107826
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0922875
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0897369
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0797653
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0773551
HLA-B major histocompatibility complex, class I, B 0.0755872
SPTBN1 spectrin, beta, non-erythrocytic 1 0.073808
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0722998
HSPA8 heat shock 70kDa protein 8 0.0705942
CALR calreticulin 0.0683383
EEF2 eukaryotic translation elongation factor 2 0.0677657
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0625161
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0600706
ASPH aspartate beta-hydroxylase 0.0576148
RPS8 ribosomal protein S8 0.0572049
EEF1G eukaryotic translation elongation factor 1 gamma 0.0566587
LDHA lactate dehydrogenase A 0.0550065
MACF1 microtubule-actin crosslinking factor 1 0.0514034
TXNRD1 thioredoxin reductase 1 0.0507506
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0501394
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0498388
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0488096
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0462117
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0456091
RPL23 ribosomal protein L23 0.0432663
RPS12 ribosomal protein S12 0.0422414
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0410747
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0410181
PCBP2 poly(rC) binding protein 2 0.040623
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0403273
PFN1 profilin 1 0.0395718
MCL1 myeloid cell leukemia 1 0.0391943
RPS3 ribosomal protein S3 0.0391022
HMGA1 high mobility group AT-hook 1 0.0388554
RPL3 ribosomal protein L3 0.0388462
RPL26 ribosomal protein L26 0.0385847
SOD2 superoxide dismutase 2, mitochondrial 0.0378228
UBC ubiquitin C 0.0367515
MYH9 myosin, heavy chain 9, non-muscle 0.0364394
PDE4D phosphodiesterase 4D, cAMP-specific 0.0354334
GANAB glucosidase, alpha; neutral AB 0.0353293
TPT1 tumor protein, translationally-controlled 1 0.0353016
MT1X metallothionein 1X 0.0349685
SFPQ splicing factor proline/glutamine-rich 0.034921
IL6 interleukin 6 0.0346292
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0345701
PDIA3 protein disulfide isomerase family A, member 3 0.0342826
PDIA6 protein disulfide isomerase family A, member 6 0.0339594
ENO1 enolase 1, (alpha) 0.033832
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0335007
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0334229
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0325062
SMOC1 SPARC related modular calcium binding 1 0.0317843
HLA-A major histocompatibility complex, class I, A 0.0317498
RPS2 ribosomal protein S2 0.0316912
RPL37A ribosomal protein L37a 0.0316556
GRAMD1B GRAM domain containing 1B 0.0314333
RPL6 ribosomal protein L6 0.0314101
ADAR adenosine deaminase, RNA-specific 0.0305617
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0302219
TLN1 talin 1 0.0297597
RAB7A RAB7A, member RAS oncogene family 0.0296755
VASP vasodilator-stimulated phosphoprotein 0.0296728
NCKAP1 NCK-associated protein 1 0.0294681
TM4SF1 transmembrane 4 L six family member 1 0.0291879
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0288728
CANX calnexin 0.0286733
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.028216
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0281118
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0279238
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0278639
SIK3 SIK family kinase 3 0.0274072
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0273615
RPL13A ribosomal protein L13a 0.0272097
CLU clusterin 0.0270398
HLA-C major histocompatibility complex, class I, C 0.0264439
BRD2 bromodomain containing 2 0.0263779
RPS13 ribosomal protein S13 0.0261537
POTEF POTE ankyrin domain family, member F 0.026142
CTSL cathepsin L 0.0260781
SQSTM1 sequestosome 1 0.0257451
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0250706
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0249894
RPS7 ribosomal protein S7 0.024919
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0248078
BASP1 brain abundant, membrane attached signal protein 1 0.0246943
FLNA filamin A, alpha 0.0246538
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0243579
KIF5B kinesin family member 5B 0.0243247
MSN moesin 0.0239174
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0236252
EIF4A3 eukaryotic translation initiation factor 4A3 0.0234846

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.252218
VIM vimentin -0.184755
FTL ferritin, light polypeptide -0.178943
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.115332
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0935429
RPLP1 ribosomal protein, large, P1 -0.0829765
PTMA prothymosin, alpha -0.0776082
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0721069
BICC1 BicC family RNA binding protein 1 -0.0613688
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0567068
CAVIN1 caveolae associated protein 1 -0.0557839
TFPI2 tissue factor pathway inhibitor 2 -0.0523343
THSD4 thrombospondin, type I, domain containing 4 -0.0471919
RPL31 ribosomal protein L31 -0.0437388
PKM pyruvate kinase, muscle -0.0431325
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0393814
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0391117
AK1 adenylate kinase 1 -0.0388213
BIRC3 baculoviral IAP repeat containing 3 -0.0360026
IER3 immediate early response 3 -0.0351412
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0348408
USP34 ubiquitin specific peptidase 34 -0.0336152
S100A6 S100 calcium binding protein A6 -0.0329822
GNAS GNAS complex locus -0.0324164
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0319715
OSMR oncostatin M receptor -0.0319178
VDAC1 voltage-dependent anion channel 1 -0.0311947
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0311247
SNX14 sorting nexin 14 -0.0310625
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0303059
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0300639
NAV3 neuron navigator 3 -0.0294828
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0292813
NHSL1 NHS-like 1 -0.0290702
RPS20 ribosomal protein S20 -0.0288529
SOX4 SRY (sex determining region Y)-box 4 -0.0288486
BABAM2 BRISC and BRCA1 A complex member 2 -0.0283794
RPLP0 ribosomal protein, large, P0 -0.0275388
ZBTB20 zinc finger and BTB domain containing 20 -0.027011
RPS24 ribosomal protein S24 -0.0269922
RPS5 ribosomal protein S5 -0.0266704
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0266254
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0259455
EFNA5 ephrin-A5 -0.025935
DENND4A DENN/MADD domain containing 4A -0.0258526
RPL4 ribosomal protein L4 -0.0258425
TTC28 tetratricopeptide repeat domain 28 -0.025441
NEBL nebulette -0.0253444
CENPF centromere protein F, 350/400kDa -0.0252971
ERBIN erbb2 interacting protein -0.0250859
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0250593
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0250369
CFDP1 craniofacial development protein 1 -0.0249877
RBM25 RNA binding motif protein 25 -0.0249768
TPM4 tropomyosin 4 -0.024792
CFLAR CASP8 and FADD-like apoptosis regulator -0.0247642
SLC35F3 solute carrier family 35, member F3 -0.0247607
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0246333
RAB10 RAB10, member RAS oncogene family -0.0242715
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0240823
PARK7 parkinson protein 7 -0.0239876
HMGA2 high mobility group AT-hook 2 -0.0234724
RPL19 ribosomal protein L19 -0.0232834
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0231647
SHTN1 shootin 1 -0.023091
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0229226
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0227607
RPL30 ribosomal protein L30 -0.0226439
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0226376
KPNB1 karyopherin (importin) beta 1 -0.0226355
NPC1 Niemann-Pick disease, type C1 -0.0226158
TRIO trio Rho guanine nucleotide exchange factor -0.0225743
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0222862
BTG1 B-cell translocation gene 1, anti-proliferative -0.0220409
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0220101
MIS18BP1 MIS18 binding protein 1 -0.0218124
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0217486
BZW1 basic leucine zipper and W2 domains 1 -0.0216624
RASAL2 RAS protein activator like 2 -0.0216303
TMEM131 transmembrane protein 131 -0.0214456
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0214129
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0211797
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0210636
TUT4 terminal uridylyl transferase 4 -0.0209642
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0209155
SEPTIN7 septin 7 -0.0206288
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0202394
PDE8A phosphodiesterase 8A -0.020231
PCNX4 pecanex 4 -0.0200816
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0200425
BIRC6 baculoviral IAP repeat containing 6 -0.019754
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0196081
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0195575
MYL12B myosin, light chain 12B, regulatory -0.0195514
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma -0.0190227
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0189361
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0189192
TUBA1C tubulin, alpha 1c -0.0187368
NRG1 neuregulin 1 -0.0186218
ACACA acetyl-CoA carboxylase alpha -0.0185768