| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Isocorydine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Isocorydine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNA5 | ephrin-A5 | 0.095935 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0817719 |
| IGF2 | insulin-like growth factor 2 | 0.080932 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0757402 |
| FNDC3B | fibronectin type III domain containing 3B | 0.070125 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0642626 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0638818 |
| LAMB3 | laminin, beta 3 | 0.0628677 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.062002 |
| NAV2 | neuron navigator 2 | 0.059154 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0563765 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0540757 |
| FLNB | filamin B, beta | 0.0531535 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.052647 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0506684 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0497843 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0483769 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0470002 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0468 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0456018 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0448083 |
| KYNU | kynureninase | 0.0446091 |
| RUNX1 | runt-related transcription factor 1 | 0.0440325 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0432801 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0426169 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0425254 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0424779 |
| LAMC2 | laminin, gamma 2 | 0.0422618 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0414851 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0404612 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0400831 |
| SPAG9 | sperm associated antigen 9 | 0.0398956 |
| ASPH | aspartate beta-hydroxylase | 0.0398499 |
| TXNRD1 | thioredoxin reductase 1 | 0.039819 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0385215 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0381923 |
| USP53 | ubiquitin specific peptidase 53 | 0.0378604 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0377731 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0375876 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0371277 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.037025 |
| EGFR | epidermal growth factor receptor | 0.0368474 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0364549 |
| FMNL2 | formin-like 2 | 0.0363254 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0360712 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0360406 |
| SEPTIN9 | septin 9 | 0.0356984 |
| TJP1 | tight junction protein 1 | 0.0356969 |
| ANXA1 | annexin A1 | 0.0356943 |
| GOLGA4 | golgin A4 | 0.0356846 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0355435 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0355327 |
| DTNA | dystrobrevin, alpha | 0.0352713 |
| SRPK1 | SRSF protein kinase 1 | 0.0335535 |
| SETD2 | SET domain containing 2 | 0.0334023 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0330243 |
| OGA | O-GlcNAcase | 0.0326578 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0325974 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0325745 |
| PDE10A | phosphodiesterase 10A | 0.0325173 |
| PLEC | plectin | 0.0325099 |
| WDR45B | WD repeat domain 45B | 0.0323655 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0321482 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0317038 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0316654 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.0314347 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0312915 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.031096 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.031014 |
| FLNA | filamin A, alpha | 0.0305049 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0303472 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0301971 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0301022 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0299089 |
| STK17A | serine/threonine kinase 17a | 0.0295093 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0292866 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.0286359 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0285403 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0284467 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0281957 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0281307 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0281261 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.028011 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0277354 |
| MFF | mitochondrial fission factor | 0.0276881 |
| CDH13 | cadherin 13 | 0.0276118 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0274868 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0273517 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.027254 |
| PHF3 | PHD finger protein 3 | 0.0271498 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.027124 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0267231 |
| CDCP1 | CUB domain containing protein 1 | 0.0266664 |
| MEMO1 | mediator of cell motility 1 | 0.026653 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0265119 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.0264824 |
| KRT17 | keratin 17, type I | 0.0263507 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0263186 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0263152 |
| HDAC9 | histone deacetylase 9 | 0.026206 |
| Symbol | Name | Standardized Value |
|---|---|---|
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.153751 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.14853 |
| MUC16 | mucin 16, cell surface associated | -0.135052 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.102035 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0937285 |
| ATOSA | atos homolog A | -0.087022 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0865373 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0851821 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0791429 |
| LMO7 | LIM domain 7 | -0.0783439 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0741793 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0736373 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0734365 |
| GPC6 | glypican 6 | -0.0668465 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0630961 |
| SVIL | supervillin | -0.0630533 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0617445 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0616496 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0611094 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0589462 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0578501 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0559465 |
| TAOK3 | TAO kinase 3 | -0.0547833 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0533474 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0530156 |
| ERBIN | erbb2 interacting protein | -0.0520713 |
| SRPK2 | SRSF protein kinase 2 | -0.0517321 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0512567 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0501047 |
| JUP | junction plakoglobin | -0.049572 |
| DST | dystonin | -0.0488944 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0483229 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0482963 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0479861 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0479464 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0473061 |
| FN1 | fibronectin 1 | -0.0462345 |
| OSMR | oncostatin M receptor | -0.0459224 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.045119 |
| SLMAP | sarcolemma associated protein | -0.0444488 |
| AK1 | adenylate kinase 1 | -0.0444269 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0437722 |
| FMN1 | formin 1 | -0.0434578 |
| NEK7 | NIMA-related kinase 7 | -0.0430656 |
| MYO5B | myosin VB | -0.0421658 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0421091 |
| FDPS | farnesyl diphosphate synthase | -0.0415668 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0413351 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0413296 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.04108 |
| LDLR | low density lipoprotein receptor | -0.0407338 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0403648 |
| ETV6 | ets variant 6 | -0.0403067 |
| FOXO1 | forkhead box O1 | -0.0401571 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0399665 |
| EXOC4 | exocyst complex component 4 | -0.0398032 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0395215 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0391207 |
| CDK14 | cyclin-dependent kinase 14 | -0.038634 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0384426 |
| STEAP4 | STEAP family member 4 | -0.0384198 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0378431 |
| NPSR1 | neuropeptide S receptor 1 | -0.037089 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.0368953 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0367261 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0364671 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0360725 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0358109 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0357822 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0357395 |
| VGF | VGF nerve growth factor inducible | -0.0357368 |
| EZR | ezrin | -0.0356735 |
| CXXC1 | CXXC finger protein 1 | -0.0356191 |
| CD2AP | CD2-associated protein | -0.0356146 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0355001 |
| CNKSR3 | CNKSR family member 3 | -0.0353271 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.035161 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0350377 |
| TOP1 | topoisomerase (DNA) I | -0.0349993 |
| PLAU | plasminogen activator, urokinase | -0.0349916 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0344758 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0343534 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.0343195 |
| CUX1 | cut-like homeobox 1 | -0.0341654 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0340584 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0340303 |
| NBEAL1 | neurobeachin-like 1 | -0.033636 |
| NAV1 | neuron navigator 1 | -0.0335623 |
| SH3PXD2A | SH3 and PX domains 2A | -0.033354 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0333494 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0330916 |
| RCOR1 | REST corepressor 1 | -0.0327485 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.03251 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0324976 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0323184 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0321724 |
| WASL | Wiskott-Aldrich syndrome-like | -0.03209 |
| PTEN | phosphatase and tensin homolog | -0.0320376 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0320043 |
| CMIP | c-Maf inducing protein | -0.031824 |
