| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Isocorydine perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Isocorydine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.242172 |
| TPM3 | tropomyosin 3 | 0.0879849 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0765848 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.072612 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0697999 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0661087 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0659112 |
| TXNRD1 | thioredoxin reductase 1 | 0.057235 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.05604 |
| ATP11A | ATPase, class VI, type 11A | 0.056039 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.054299 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0539519 |
| COPA | coatomer protein complex, subunit alpha | 0.0528202 |
| RTN4 | reticulon 4 | 0.0505389 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0503325 |
| SFPQ | splicing factor proline/glutamine-rich | 0.048392 |
| TMEM41B | transmembrane protein 41B | 0.0460163 |
| GRAMD1B | GRAM domain containing 1B | 0.0455751 |
| EGR1 | early growth response 1 | 0.0445967 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0424043 |
| VMP1 | vacuole membrane protein 1 | 0.0412079 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0403149 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0392865 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0375528 |
| MSN | moesin | 0.0361696 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0355998 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0354873 |
| LATS2 | large tumor suppressor kinase 2 | 0.035267 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0347771 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0347285 |
| KLF6 | Kruppel-like factor 6 | 0.0345506 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0343334 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.034158 |
| MEF2D | myocyte enhancer factor 2D | 0.033795 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0337911 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0335722 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0335713 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0334471 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.0329092 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0326762 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0323902 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0322113 |
| BRD2 | bromodomain containing 2 | 0.0318629 |
| ACTN1 | actinin, alpha 1 | 0.0317793 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0314744 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0311312 |
| CTTNBP2NL | CTTNBP2 N-terminal like | 0.0307307 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.030547 |
| CALU | calumenin | 0.0303604 |
| TLN1 | talin 1 | 0.0300663 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0297346 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0289552 |
| CTTN | cortactin | 0.0287068 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0286659 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0282457 |
| R3HDM2 | R3H domain containing 2 | 0.0281516 |
| BRD4 | bromodomain containing 4 | 0.0277823 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0276279 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0275268 |
| USP36 | ubiquitin specific peptidase 36 | 0.0274657 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0267801 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0256443 |
| CRY1 | cryptochrome circadian clock 1 | 0.0254806 |
| GSE1 | Gse1 coiled-coil protein | 0.0254755 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0253171 |
| GOLGA3 | golgin A3 | 0.0252787 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0250748 |
| ATXN2 | ataxin 2 | 0.0248854 |
| DIDO1 | death inducer-obliterator 1 | 0.0248733 |
| PCBP2 | poly(rC) binding protein 2 | 0.0241338 |
| KIF1A | kinesin family member 1A | 0.02413 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0240724 |
| AHCYL1 | adenosylhomocysteinase-like 1 | 0.0238159 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0237588 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0237331 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0235968 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0235108 |
| IGF2 | insulin-like growth factor 2 | 0.0234742 |
| GOLGB1 | golgin B1 | 0.0234491 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0234286 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0231031 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0230326 |
| RRP12 | ribosomal RNA processing 12 homolog (S. cerevisiae) | 0.0228781 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0228099 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0228026 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0227564 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0226552 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0225458 |
| RUNX1 | runt-related transcription factor 1 | 0.0224939 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0224363 |
| GANAB | glucosidase, alpha; neutral AB | 0.0223089 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.0222661 |
| CDK17 | cyclin-dependent kinase 17 | 0.0221403 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0220034 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0219562 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0219412 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0217265 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.021653 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0216307 |
| STK4 | serine/threonine kinase 4 | 0.0214825 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.157732 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.156865 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.140721 |
| PTMA | prothymosin, alpha | -0.13884 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.118664 |
| RAD51B | RAD51 paralog B | -0.110028 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0964538 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0942586 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0784171 |
| HMGA2 | high mobility group AT-hook 2 | -0.0728547 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0703798 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.067683 |
| TMSB10 | thymosin beta 10 | -0.066951 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0655308 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0643174 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0618215 |
| VIM | vimentin | -0.0613864 |
| EXOC4 | exocyst complex component 4 | -0.0587808 |
| RYR3 | ryanodine receptor 3 | -0.0569681 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0564565 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0554702 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0552318 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0551101 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0550338 |
| BBX | bobby sox homolog (Drosophila) | -0.0547634 |
| PRELID2 | PRELI domain containing 2 | -0.0539561 |
| GNAS | GNAS complex locus | -0.0488717 |
| TPI1 | triosephosphate isomerase 1 | -0.0484699 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0480526 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0476047 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0457688 |
| ACTG1 | actin gamma 1 | -0.0456389 |
| PHIP | pleckstrin homology domain interacting protein | -0.0434811 |
| ATXN1 | ataxin 1 | -0.0432283 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0428476 |
| CENPF | centromere protein F, 350/400kDa | -0.0426798 |
| RPS24 | ribosomal protein S24 | -0.0424355 |
| EFNA5 | ephrin-A5 | -0.0418697 |
| RPL12 | ribosomal protein L12 | -0.0407225 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0400581 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0394872 |
| RSF1 | remodeling and spacing factor 1 | -0.0390143 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0389846 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0385053 |
| H1-0 | H1.0 linker histone | -0.0377879 |
| AEBP2 | AE binding protein 2 | -0.037749 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0373405 |
| AHNAK | AHNAK nucleoprotein | -0.0370002 |
| FMN1 | formin 1 | -0.0367328 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0363539 |
| RPLP1 | ribosomal protein, large, P1 | -0.036296 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0356708 |
| TBC1D5 | TBC1 domain family, member 5 | -0.035647 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0356445 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0354959 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0350355 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.034592 |
| RPLP0 | ribosomal protein, large, P0 | -0.0341181 |
| USP34 | ubiquitin specific peptidase 34 | -0.0338201 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0337542 |
| DEK | DEK proto-oncogene | -0.0333435 |
| WWOX | WW domain containing oxidoreductase | -0.032964 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.032455 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0320873 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0320113 |
| THOC2 | THO complex 2 | -0.0319839 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0318683 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0314304 |
| CD2AP | CD2-associated protein | -0.0312407 |
| RYK | receptor-like tyrosine kinase | -0.0309838 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0309509 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0303584 |
| DIAPH2 | diaphanous-related formin 2 | -0.0303469 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0301835 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0301284 |
| KIAA1328 | KIAA1328 | -0.0299144 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0298011 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0296735 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0295779 |
| DIAPH3 | diaphanous-related formin 3 | -0.0289911 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0289675 |
| SEPTIN7 | septin 7 | -0.0288638 |
| LDHB | lactate dehydrogenase B | -0.0288376 |
| CBX3 | chromobox homolog 3 | -0.0286677 |
| DENND1A | DENN/MADD domain containing 1A | -0.0284647 |
| TPX2 | TPX2, microtubule-associated | -0.0283834 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0277608 |
| ENOSF1 | enolase superfamily member 1 | -0.02766 |
| TUBB | tubulin, beta class I | -0.0269952 |
| COMMD10 | COMM domain containing 10 | -0.0269679 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0267848 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0267504 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0265952 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0264969 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.026465 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0264425 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | -0.0263348 |
| NEK10 | NIMA-related kinase 10 | -0.0261522 |
| SGO2 | shugoshin 2 | -0.0258091 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0256441 |
