| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Isocorydine perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Isocorydine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.218895 |
| COL11A1 | collagen, type XI, alpha 1 | 0.181492 |
| COL5A2 | collagen, type V, alpha 2 | 0.122995 |
| PEG10 | paternally expressed 10 | 0.119313 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.116525 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0911665 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0784492 |
| FOXP2 | forkhead box P2 | 0.0571078 |
| MKI67 | marker of proliferation Ki-67 | 0.0558607 |
| PRTG | protogenin | 0.0542898 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0501621 |
| CALR | calreticulin | 0.0500596 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0478001 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0474718 |
| FNDC3A | fibronectin type III domain containing 3A | 0.041287 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0401432 |
| NCKAP1 | NCK-associated protein 1 | 0.0395614 |
| PCBP2 | poly(rC) binding protein 2 | 0.0394853 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0392347 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0392102 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0378753 |
| GPC3 | glypican 3 | 0.0371145 |
| PDGFC | platelet derived growth factor C | 0.0367731 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0365446 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0355602 |
| USP22 | ubiquitin specific peptidase 22 | 0.0348348 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0338285 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0329629 |
| EGFR | epidermal growth factor receptor | 0.0320975 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0312686 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0305069 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0292571 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0289226 |
| POTEF | POTE ankyrin domain family, member F | 0.0277064 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0273249 |
| NFIB | nuclear factor I/B | 0.0271458 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0265232 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0262851 |
| RPS12 | ribosomal protein S12 | 0.0262462 |
| LRRC4C | leucine rich repeat containing 4C | 0.0262117 |
| GANAB | glucosidase, alpha; neutral AB | 0.0261267 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0260955 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0258394 |
| CNTN6 | contactin 6 | 0.0257201 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0256409 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0255821 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0254699 |
| ZNF462 | zinc finger protein 462 | 0.0254095 |
| APP | amyloid beta (A4) precursor protein | 0.0253133 |
| RPS2 | ribosomal protein S2 | 0.0253009 |
| TPM3 | tropomyosin 3 | 0.025224 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0248576 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0246176 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0245278 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0244777 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0244012 |
| MYH10 | myosin, heavy chain 10, non-muscle | 0.0243438 |
| SARS1 | seryl-tRNA synthetase 1 | 0.0241623 |
| RNF213 | ring finger protein 213 | 0.0239821 |
| EXOC4 | exocyst complex component 4 | 0.0238246 |
| CSRNP3 | cysteine-serine-rich nuclear protein 3 | 0.0237758 |
| GOLGA4 | golgin A4 | 0.0236427 |
| PCDH18 | protocadherin 18 | 0.0233613 |
| CALU | calumenin | 0.0232346 |
| PFN1 | profilin 1 | 0.0231496 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0228068 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0226827 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0226644 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.0224806 |
| SRPK2 | SRSF protein kinase 2 | 0.0224714 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0224293 |
| RBM6 | RNA binding motif protein 6 | 0.0222972 |
| FAM117B | family with sequence similarity 117, member B | 0.0219916 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0218162 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.021781 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0216513 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0215903 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.021502 |
| NF1 | neurofibromin 1 | 0.021346 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0213449 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0211528 |
| TTC21B | tetratricopeptide repeat domain 21B | 0.0211058 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0210658 |
| KIF5B | kinesin family member 5B | 0.0210296 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0209845 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 0.0209675 |
| FAT1 | FAT atypical cadherin 1 | 0.0209259 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0209074 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0206422 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0204528 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0204313 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0203944 |
| COL3A1 | collagen, type III, alpha 1 | 0.020189 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0200903 |
| AFDN | afadin, adherens junction formation factor | 0.020021 |
| RPL26 | ribosomal protein L26 | 0.0198026 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0197903 |
| MED12L | mediator complex subunit 12-like | 0.0197388 |
| TFG | TRK-fused gene | 0.0196096 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0195394 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.129311 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.10767 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.091628 |
| VIM | vimentin | -0.0910427 |
| PTMA | prothymosin, alpha | -0.0898486 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0881359 |
| PLPP1 | phospholipid phosphatase 1 | -0.0851361 |
| CADM2 | cell adhesion molecule 2 | -0.0792707 |
| NTM | neurotrimin | -0.0724786 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0671275 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0642088 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.058734 |
| RASAL2 | RAS protein activator like 2 | -0.0571186 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0564089 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0536584 |
| NRG1 | neuregulin 1 | -0.0519352 |
| EMP1 | epithelial membrane protein 1 | -0.051778 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0504065 |
| CDC73 | cell division cycle 73 | -0.0481564 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0480844 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0474231 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0474124 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0470728 |
| HDAC9 | histone deacetylase 9 | -0.0459405 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0446287 |
| RAI1 | retinoic acid induced 1 | -0.0444661 |
| TMSB4X | thymosin beta 4, X-linked | -0.0439735 |
| AHNAK | AHNAK nucleoprotein | -0.0430204 |
| ANKRD33B | ankyrin repeat domain 33B | -0.041659 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.041546 |
| TMSB10 | thymosin beta 10 | -0.0412384 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0409569 |
| GNAS | GNAS complex locus | -0.0404445 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0396935 |
| NHSL1 | NHS-like 1 | -0.0394729 |
| LYST | lysosomal trafficking regulator | -0.0390076 |
| MED13L | mediator complex subunit 13-like | -0.0389282 |
| HMGB1 | high mobility group box 1 | -0.0367977 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0367167 |
| NEBL | nebulette | -0.0365085 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0361081 |
| USP53 | ubiquitin specific peptidase 53 | -0.0359246 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.03585 |
| RPLP1 | ribosomal protein, large, P1 | -0.0357148 |
| HMGA2 | high mobility group AT-hook 2 | -0.0350345 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.034709 |
| RPS24 | ribosomal protein S24 | -0.0346954 |
| ZNF217 | zinc finger protein 217 | -0.0344088 |
| COL1A2 | collagen, type I, alpha 2 | -0.0342349 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.034058 |
| MPG | N-methylpurine-DNA glycosylase | -0.0332941 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0325422 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0321629 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.031438 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.030926 |
| USH2A | Usher syndrome 2A (autosomal recessive, mild) | -0.030609 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0305137 |
| FBXO11 | F-box protein 11 | -0.0300752 |
| UTRN | utrophin | -0.0299009 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0296583 |
| PALLD | palladin, cytoskeletal associated protein | -0.0295624 |
| PRELID2 | PRELI domain containing 2 | -0.0289631 |
| CAVIN1 | caveolae associated protein 1 | -0.0283626 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0283581 |
| FILIP1 | filamin A interacting protein 1 | -0.0280785 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0278275 |
| CERT1 | ceramide transporter 1 | -0.0275793 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.027568 |
| RDX | radixin | -0.0275071 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0274645 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0272578 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0272516 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0270329 |
| MAP4 | microtubule-associated protein 4 | -0.0270278 |
| SRP54 | signal recognition particle 54kDa | -0.0267164 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0265588 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0265266 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0264762 |
| DENND5B | DENN/MADD domain containing 5B | -0.0264254 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0264038 |
| CPA6 | carboxypeptidase A6 | -0.0263495 |
| JMJD1C | jumonji domain containing 1C | -0.0262512 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0262371 |
| RAD51B | RAD51 paralog B | -0.026235 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0261639 |
| PRR16 | proline rich 16 | -0.0260538 |
| PCDH9 | protocadherin 9 | -0.0257852 |
| DST | dystonin | -0.0255947 |
| KLHL5 | kelch-like family member 5 | -0.0254563 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0254399 |
| RTN4 | reticulon 4 | -0.0253613 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0252616 |
| TNS3 | tensin 3 | -0.0252513 |
| SLC44A5 | solute carrier family 44, member 5 | -0.0252468 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0250922 |
| ZNF385D | zinc finger protein 385D | -0.0249352 |
| UPP1 | uridine phosphorylase 1 | -0.0249118 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.024776 |
| BTBD3 | BTB (POZ) domain containing 3 | -0.0247383 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0246192 |
