Isocorydine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Isocorydine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Isocorydine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.130645
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.12649
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.108045
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0963782
COL6A3 collagen, type VI, alpha 3 0.0826364
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.076086
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0749612
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0728307
VEGFA vascular endothelial growth factor A 0.0715255
ARRDC3 arrestin domain containing 3 0.0644046
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0566689
VMP1 vacuole membrane protein 1 0.0538632
LDHA lactate dehydrogenase A 0.0526452
HLA-B major histocompatibility complex, class I, B 0.0512561
EEF1G eukaryotic translation elongation factor 1 gamma 0.050448
EEF2 eukaryotic translation elongation factor 2 0.0485996
FTH1 ferritin, heavy polypeptide 1 0.0448427
KLF6 Kruppel-like factor 6 0.0439354
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0415455
PPARD peroxisome proliferator-activated receptor delta 0.0393518
TENT5A terminal nucleotidyltransferase 5A 0.0378878
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0375853
FLNA filamin A, alpha 0.0363219
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0358316
MT2A metallothionein 2A 0.0356932
EGR1 early growth response 1 0.0354391
GANAB glucosidase, alpha; neutral AB 0.0347382
MSN moesin 0.0339266
ICAM1 intercellular adhesion molecule 1 0.0336179
TPM3 tropomyosin 3 0.033266
PCBP2 poly(rC) binding protein 2 0.0327876
SMAD3 SMAD family member 3 0.0317335
RPS12 ribosomal protein S12 0.0315597
GPC6 glypican 6 0.0296254
RTN4 reticulon 4 0.0294751
HSPA8 heat shock 70kDa protein 8 0.0294718
FN1 fibronectin 1 0.0293508
RPL13A ribosomal protein L13a 0.0286544
RPL6 ribosomal protein L6 0.0281102
CALR calreticulin 0.0269764
DDIT4 DNA-damage-inducible transcript 4 0.0258595
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0254514
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0252266
MKI67 marker of proliferation Ki-67 0.0244965
RPS2 ribosomal protein S2 0.0242107
ENO1 enolase 1, (alpha) 0.0241865
RND3 Rho family GTPase 3 0.0238913
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0235621
RPL26 ribosomal protein L26 0.0230489
NDRG1 N-myc downstream regulated 1 0.0227018
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.022653
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0222989
HMGA1 high mobility group AT-hook 1 0.0220792
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0219416
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0219162
RPL5 ribosomal protein L5 0.0219068
SFPQ splicing factor proline/glutamine-rich 0.0215368
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0215319
IGF2 insulin-like growth factor 2 0.0213055
YBX1 Y box binding protein 1 0.0212024
RPS3 ribosomal protein S3 0.0203687
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0202326
CD59 CD59 molecule, complement regulatory protein 0.0200844
NCKAP1 NCK-associated protein 1 0.0200344
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0199959
RPL23 ribosomal protein L23 0.0197489
CCNL1 cyclin L1 0.0197217
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0196212
SEPTIN9 septin 9 0.0196139
CALU calumenin 0.0193362
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0190959
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0190153
ATXN1 ataxin 1 0.0188851
SQSTM1 sequestosome 1 0.0187801
APLP2 amyloid beta (A4) precursor-like protein 2 0.0187466
CD68 CD68 molecule 0.0187451
ZNF84 zinc finger protein 84 0.0186141
STC2 stanniocalcin 2 0.0184292
TNIP1 TNFAIP3 interacting protein 1 0.0182449
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0181013
FLNB filamin B, beta 0.0180923
DUSP5 dual specificity phosphatase 5 0.0178361
CTSB cathepsin B 0.0177345
RAD23B RAD23 homolog B (S. cerevisiae) 0.0177018
OPTN optineurin 0.0174108
CEP250 centrosomal protein 250kDa 0.0172308
ACTN4 actinin, alpha 4 0.0171386
HLA-C major histocompatibility complex, class I, C 0.0170457
SDC4 syndecan 4 0.0169874
TXNIP thioredoxin interacting protein 0.0167815
POTEF POTE ankyrin domain family, member F 0.016656
ANLN anillin, actin binding protein 0.0166377
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0164484
KLF10 Kruppel-like factor 10 0.0163955
MLPH melanophilin 0.0162874
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0161977
WWTR1 WW domain containing transcription regulator 1 0.0160032
GADD45B growth arrest and DNA-damage-inducible, beta 0.0159809
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0158374
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0155477

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.20742
FRMD4A FERM domain containing 4A -0.167344
AKAP12 A kinase (PRKA) anchor protein 12 -0.114318
IER3 immediate early response 3 -0.104141
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.100331
BTG1 B-cell translocation gene 1, anti-proliferative -0.0852139
CADM1 cell adhesion molecule 1 -0.0846586
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0828409
PLIN2 perilipin 2 -0.0822367
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0812925
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0792721
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0787689
CDH13 cadherin 13 -0.075507
HMGA2 high mobility group AT-hook 2 -0.0732413
TMSB10 thymosin beta 10 -0.0728269
DIAPH2 diaphanous-related formin 2 -0.0726601
FTL ferritin, light polypeptide -0.066886
TMSB4X thymosin beta 4, X-linked -0.0658425
PDE10A phosphodiesterase 10A -0.0650971
GNAS GNAS complex locus -0.0638953
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0630352
TRIO trio Rho guanine nucleotide exchange factor -0.0614818
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0613923
ZMYND8 zinc finger, MYND-type containing 8 -0.0604414
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0595405
RPS24 ribosomal protein S24 -0.0570716
GLIS3 GLIS family zinc finger 3 -0.0565669
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0562926
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0546171
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0530747
KYNU kynureninase -0.0522452
DLG1 discs, large homolog 1 (Drosophila) -0.0521174
FRMPD4 FERM and PDZ domain containing 4 -0.0515399
RAI14 retinoic acid induced 14 -0.0514607
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0512959
MMP12 matrix metallopeptidase 12 -0.0507429
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0488417
AFF3 AF4/FMR2 family, member 3 -0.0485019
INTS6 integrator complex subunit 6 -0.0483907
ZBTB20 zinc finger and BTB domain containing 20 -0.0481137
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0468085
EGFR epidermal growth factor receptor -0.0465835
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0462868
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0453017
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0442335
SLC38A1 solute carrier family 38, member 1 -0.043905
PTPRK protein tyrosine phosphatase, receptor type, K -0.0434916
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0434556
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0428599
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0421753
VCAN versican -0.0420153
PTMA prothymosin, alpha -0.0418134
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0404075
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0402234
CLIC4 chloride intracellular channel 4 -0.0389555
ZFAND3 zinc finger, AN1-type domain 3 -0.0386413
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0379755
CLMP CXADR-like membrane protein -0.0379057
RPLP1 ribosomal protein, large, P1 -0.0373384
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0368124
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0367023
PGK1 phosphoglycerate kinase 1 -0.0364142
NRN1 neuritin 1 -0.0353246
PHF3 PHD finger protein 3 -0.0350126
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0349648
SAMD3 sterile alpha motif domain containing 3 -0.034822
IFI16 interferon, gamma-inducible protein 16 -0.0342234
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0339541
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.033648
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0331129
SOD2 superoxide dismutase 2, mitochondrial -0.0330012
TUBB tubulin, beta class I -0.0329705
ZBTB38 zinc finger and BTB domain containing 38 -0.0328341
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0327628
SP100 SP100 nuclear antigen -0.0326601
TKT transketolase -0.0325567
AFF4 AF4/FMR2 family, member 4 -0.0322351
TMEM132D transmembrane protein 132D -0.0321932
FNIP1 folliculin interacting protein 1 -0.031978
FBXO32 F-box protein 32 -0.0318549
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0318075
NAV1 neuron navigator 1 -0.0315779
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.0309772
RPS4X ribosomal protein S4, X-linked -0.0302891
FBXO11 F-box protein 11 -0.0300982
COL1A1 collagen, type I, alpha 1 -0.0299162
INHBA inhibin, beta A -0.0295295
BNC2 basonuclin 2 -0.0294307
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0291195
QKI QKI, KH domain containing, RNA binding -0.0289094
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0286873
PKM pyruvate kinase, muscle -0.028613
SLC35F3 solute carrier family 35, member F3 -0.0285682
RRBP1 ribosome binding protein 1 -0.028285
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.028276
PSD3 pleckstrin and Sec7 domain containing 3 -0.0281449
CAVIN1 caveolae associated protein 1 -0.0276149
TMEM263 transmembrane protein 263 -0.0276074
SPDYA speedy/RINGO cell cycle regulator family member A -0.0272965
ENO2 enolase 2 (gamma, neuronal) -0.0272097