| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A retinoic acid that is all-trans-retinoic acid in which the double bond which is alpha,beta- to the carboxy group is isomerised to Z configuration. A synthetic retinoid, it is used for the treatment of severe cases of acne and other skin diseases. (Chemical Entities of Biological Interest Ontology, CHEBI_6067) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5282379 |
| Similar Terms | |
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199 proteins with high or low expression in Isotretinoin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SRD5A3 | steroid 5 alpha-reductase 3 | 2.91 |
| HMOX1 | heme oxygenase 1 | 1.8 |
| FAM160A1 | family with sequence similarity 160, member A1 | 0.98 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 0.94 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 0.94 |
| CPTP | ceramide-1-phosphate transfer protein | 0.81 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | 0.81 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.78 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 0.57 |
| PSEN2 | presenilin 2 | 0.56 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.53 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.53 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.51 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | 0.5 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.49 |
| ZC3H6 | zinc finger CCCH-type containing 6 | 0.49 |
| MAGEA2 | melanoma antigen family A2 | 0.49 |
| ZFP36 | ZFP36 ring finger protein | 0.48 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.48 |
| TET2 | tet methylcytosine dioxygenase 2 | 0.46 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.45 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.44 |
| ADCK5 | aarF domain containing kinase 5 | 0.44 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.43 |
| PROS1 | protein S (alpha) | 0.43 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.43 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.42 |
| SRXN1 | sulfiredoxin 1 | 0.42 |
| WSB2 | WD repeat and SOCS box containing 2 | 0.41 |
| MYH15 | myosin, heavy chain 15 | 0.4 |
| PFDN1 | prefoldin subunit 1 | 0.4 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.4 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.39 |
| KIAA1958 | KIAA1958 | 0.39 |
| RNF181 | ring finger protein 181 | 0.39 |
| TRIM16 | tripartite motif containing 16 | 0.39 |
| ZNF7 | zinc finger protein 7 | 0.38 |
| LGALSL | lectin, galactoside-binding-like | 0.38 |
| RPL26 | ribosomal protein L26 | 0.37 |
| TXNRD1 | thioredoxin reductase 1 | 0.37 |
| BCAS2 | breast carcinoma amplified sequence 2 | 0.37 |
| MRPL12 | mitochondrial ribosomal protein L12 | 0.37 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | 0.36 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.36 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | 0.36 |
| DGKE | diacylglycerol kinase, epsilon 64kDa | 0.36 |
| SYTL3 | synaptotagmin-like 3 | 0.36 |
| AMACR | alpha-methylacyl-CoA racemase | 0.36 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.35 |
| SC5D | sterol-C5-desaturase | 0.35 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.35 |
| SOD1 | superoxide dismutase 1, soluble | 0.35 |
| HES1 | hes family bHLH transcription factor 1 | 0.35 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.35 |
| ANKRD13D | ankyrin repeat domain 13 family, member D | 0.34 |
| HSPBAP1 | HSPB (heat shock 27kDa) associated protein 1 | 0.34 |
| C14ORF93 | chromosome 14 open reading frame 93 | 0.34 |
| EPHX4 | epoxide hydrolase 4 | 0.34 |
| ZNF142 | zinc finger protein 142 | 0.34 |
| ZNF35 | zinc finger protein 35 | 0.33 |
| FZD7 | frizzled class receptor 7 | 0.33 |
| NOTCH3 | notch 3 | 0.33 |
| GID8 | GID complex subunit 8 | 0.33 |
| TRIM9 | tripartite motif containing 9 | 0.33 |
| MIGA2 | mitoguardin 2 | 0.33 |
| RNF7 | ring finger protein 7 | 0.33 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.32 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.32 |
| MRPL50 | mitochondrial ribosomal protein L50 | 0.32 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.32 |
| PACRGL | PARK2 co-regulated-like | 0.31 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.31 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | 0.31 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.31 |
| KIAA1107 | KIAA1107 | 0.31 |
| PRR3 | proline rich 3 | 0.31 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.31 |
| MSANTD4 | Myb/SANT-like DNA-binding domain containing 4 with coiled-coils | 0.31 |
| COMMD6 | COMM domain containing 6 | 0.3 |
| C18ORF32 | chromosome 18 open reading frame 32 | 0.3 |
| MYCBP | MYC binding protein | 0.3 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.3 |
| CDK14 | cyclin-dependent kinase 14 | 0.3 |
| UBQLN1 | ubiquilin 1 | 0.3 |
| KLK6 | kallikrein-related peptidase 6 | 0.3 |
| KIAA1217 | KIAA1217 | 0.29 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 0.29 |
| POMP | proteasome maturation protein | 0.29 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.29 |
| HSPA1L | heat shock 70kDa protein 1-like | 0.29 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.29 |
| ZNF57 | zinc finger protein 57 | 0.29 |
| TPK1 | thiamin pyrophosphokinase 1 | 0.29 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.29 |
| FAM110C | family with sequence similarity 110, member C | 0.29 |
| ZNF354B | zinc finger protein 354B | 0.29 |
| C2CD3 | C2 calcium-dependent domain containing 3 | 0.28 |
| ANGPTL4 | angiopoietin-like 4 | 0.28 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 0.28 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYO7B | myosin VIIB | -1.2 |
| PIP | prolactin-induced protein | -1.09 |
| CETN1 | centrin, EF-hand protein, 1 | -0.85 |
| C7 | complement component 7 | -0.82 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.69 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.66 |
| MEX3C | mex-3 RNA binding family member C | -0.65 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | -0.62 |
| OGFOD2 | 2-oxoglutarate and iron-dependent oxygenase domain containing 2 | -0.6 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.59 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.59 |
| ZFHX3 | zinc finger homeobox 3 | -0.58 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.56 |
| GAS6 | growth arrest-specific 6 | -0.53 |
| RAB36 | RAB36, member RAS oncogene family | -0.53 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.51 |
| CLTCL1 | clathrin, heavy chain-like 1 | -0.49 |
| RGS19 | regulator of G-protein signaling 19 | -0.48 |
| DENND4A | DENN/MADD domain containing 4A | -0.47 |
| MCOLN3 | mucolipin 3 | -0.46 |
| ERCC6 | excision repair cross-complementation group 6 | -0.46 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.45 |
| DISP2 | dispatched homolog 2 (Drosophila) | -0.45 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.44 |
| NOP10 | NOP10 ribonucleoprotein | -0.44 |
| ANKRD22 | ankyrin repeat domain 22 | -0.43 |
| C8ORF76 | chromosome 8 open reading frame 76 | -0.43 |
| SMIM19 | small integral membrane protein 19 | -0.42 |
| TBC1D32 | TBC1 domain family, member 32 | -0.42 |
| ZNF526 | zinc finger protein 526 | -0.41 |
| ZADH2 | zinc binding alcohol dehydrogenase domain containing 2 | -0.41 |
| SLC22A5 | solute carrier family 22 (organic cation/carnitine transporter), member 5 | -0.41 |
| MT1X | metallothionein 1X | -0.41 |
| WASHC3 | WASH complex subunit 3 | -0.4 |
| CEP85L | centrosomal protein 85kDa-like | -0.4 |
| FN1 | fibronectin 1 | -0.4 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.39 |
| ZNF655 | zinc finger protein 655 | -0.39 |
| TPPP | tubulin polymerization promoting protein | -0.39 |
| ZFAND2A | zinc finger, AN1-type domain 2A | -0.39 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | -0.38 |
| ATP23 | ATP23 metallopeptidase and ATP synthase assembly factor homolog | -0.37 |
| ICA1 | islet cell autoantigen 1, 69kDa | -0.37 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.37 |
| ABHD13 | abhydrolase domain containing 13 | -0.36 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.36 |
| MROH6 | maestro heat-like repeat family member 6 | -0.36 |
| MNX1 | motor neuron and pancreas homeobox 1 | -0.36 |
| H1-0 | H1.0 linker histone | -0.35 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | -0.35 |
| JOSD1 | Josephin domain containing 1 | -0.35 |
| PLEKHA6 | pleckstrin homology domain containing, family A member 6 | -0.35 |
| MT2A | metallothionein 2A | -0.34 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.34 |
| SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | -0.34 |
| TMEM11 | transmembrane protein 11 | -0.34 |
| HIST1H1T | histone cluster 1, H1t | -0.34 |
| ZNRD1 | zinc ribbon domain containing 1 | -0.33 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | -0.33 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | -0.33 |
| TMEM104 | transmembrane protein 104 | -0.33 |
| CKM | creatine kinase, muscle | -0.33 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.33 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.32 |
| TSPAN3 | tetraspanin 3 | -0.32 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.32 |
| PRSS12 | protease, serine, 12 (neurotrypsin, motopsin) | -0.32 |
| TMEM222 | transmembrane protein 222 | -0.32 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.32 |
| MYO15B | myosin XVB | -0.31 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.31 |
| YIPF1 | Yip1 domain family, member 1 | -0.31 |
| RTL8C | retrotransposon Gag like 8C | -0.31 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.31 |
| PLK2 | polo-like kinase 2 | -0.3 |
| MAZ | MYC-associated zinc finger protein (purine-binding transcription factor) | -0.3 |
| MT1L | metallothionein 1L (gene/pseudogene) | -0.3 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | -0.29 |
| TRAIP | TRAF interacting protein | -0.29 |
| COX18 | COX18 cytochrome c oxidase assembly factor | -0.29 |
| CNTNAP3 | contactin associated protein-like 3 | -0.29 |
| NDUFAF6 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 | -0.29 |
| RBP1 | retinol binding protein 1, cellular | -0.29 |
| TOM1L2 | target of myb1-like 2 (chicken) | -0.29 |
| ANTXR2 | anthrax toxin receptor 2 | -0.28 |
| DOP1A | DOP1 leucine zipper like protein A | -0.28 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.28 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | -0.28 |
| DUSP6 | dual specificity phosphatase 6 | -0.28 |
| PEX26 | peroxisomal biogenesis factor 26 | -0.28 |
| FGB | fibrinogen beta chain | -0.28 |
| NOP16 | NOP16 nucleolar protein | -0.28 |
| METAP1D | methionyl aminopeptidase type 1D (mitochondrial) | -0.28 |
| FKTN | fukutin | -0.28 |
| BSN | bassoon presynaptic cytomatrix protein | -0.28 |
| FAM192A | family with sequence similarity 192, member A | -0.28 |
| HMGB3 | high mobility group box 3 | -0.28 |
| BCL6 | B-cell CLL/lymphoma 6 | -0.27 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.27 |
