| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FBN1 | fibrillin 1 | 0.142388 |
| COL3A1 | collagen, type III, alpha 1 | 0.0965506 |
| AHNAK | AHNAK nucleoprotein | 0.0737563 |
| TMSB10 | thymosin beta 10 | 0.0693039 |
| AUTS2 | autism susceptibility candidate 2 | 0.0679869 |
| MT2A | metallothionein 2A | 0.0646209 |
| COL1A2 | collagen, type I, alpha 2 | 0.0613121 |
| PLAT | plasminogen activator, tissue | 0.0605019 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0592928 |
| FLNB | filamin B, beta | 0.0585828 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0553355 |
| COL5A2 | collagen, type V, alpha 2 | 0.0522044 |
| APP | amyloid beta (A4) precursor protein | 0.0509728 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0507716 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0496645 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0495056 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0491348 |
| OGA | O-GlcNAcase | 0.0489306 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0461298 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.045996 |
| GPC6 | glypican 6 | 0.0448126 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.044543 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0441247 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.042853 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0425215 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0394333 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0388216 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0385723 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0379389 |
| PRELID2 | PRELI domain containing 2 | 0.0375574 |
| ATP13A3 | ATPase type 13A3 | 0.0374877 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0373618 |
| GLIS3 | GLIS family zinc finger 3 | 0.037253 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0364722 |
| SBF2 | SET binding factor 2 | 0.0364307 |
| SEPTIN9 | septin 9 | 0.0362527 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0358019 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0350592 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.034157 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0338218 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0332226 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0328166 |
| DENND5A | DENN/MADD domain containing 5A | 0.032021 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0318579 |
| SDC4 | syndecan 4 | 0.0316584 |
| ADAR | adenosine deaminase, RNA-specific | 0.0314911 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0312821 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0312617 |
| STC1 | stanniocalcin 1 | 0.0299916 |
| FRMD5 | FERM domain containing 5 | 0.029776 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0292013 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0281576 |
| SVIL | supervillin | 0.0274995 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0272613 |
| EHBP1 | EH domain binding protein 1 | 0.0270796 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0269821 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0267721 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0259181 |
| SP3 | Sp3 transcription factor | 0.0258007 |
| KIFAP3 | kinesin-associated protein 3 | 0.0255573 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0254985 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0254126 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0251979 |
| TDRD7 | tudor domain containing 7 | 0.0251151 |
| CD44 | CD44 molecule (Indian blood group) | 0.0246864 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0242608 |
| OPTN | optineurin | 0.0238092 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0238014 |
| PTMA | prothymosin, alpha | 0.0236781 |
| AFDN | afadin, adherens junction formation factor | 0.0232981 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0231048 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0229188 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0227128 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0225409 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0225101 |
| LOXL2 | lysyl oxidase-like 2 | 0.0224433 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0222744 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0221995 |
| ABI1 | abl-interactor 1 | 0.0218339 |
| MTSS1 | metastasis suppressor 1 | 0.0216717 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0216701 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0216329 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0215953 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0213186 |
| TRIM22 | tripartite motif containing 22 | 0.0212776 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.021255 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0211096 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0210814 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0210321 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0208239 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.020787 |
| ZNF148 | zinc finger protein 148 | 0.0205884 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0204883 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0202119 |
| PCM1 | pericentriolar material 1 | 0.0201811 |
| MYOF | myoferlin | 0.020167 |
| ATXN1 | ataxin 1 | 0.0200815 |
| RUNX1 | runt-related transcription factor 1 | 0.0200743 |
| VMP1 | vacuole membrane protein 1 | 0.0199618 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0197045 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.250983 |
| PODXL | podocalyxin-like | -0.20116 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.170161 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.149998 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.111922 |
| CSTB | cystatin B (stefin B) | -0.111875 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.110617 |
| LOX | lysyl oxidase | -0.109354 |
| FN1 | fibronectin 1 | -0.106699 |
| MAP1B | microtubule-associated protein 1B | -0.103469 |
| NDRG1 | N-myc downstream regulated 1 | -0.0987571 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.095651 |
| CCND1 | cyclin D1 | -0.0951203 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0869175 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0813077 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0785391 |
| CDH13 | cadherin 13 | -0.0771932 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0726293 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0713589 |
| LDHA | lactate dehydrogenase A | -0.0705319 |
| S100A6 | S100 calcium binding protein A6 | -0.0700993 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0650176 |
| TPM4 | tropomyosin 4 | -0.0609979 |
| EGFR | epidermal growth factor receptor | -0.0590095 |
| S100A10 | S100 calcium binding protein A10 | -0.0573324 |
| DCLK2 | doublecortin-like kinase 2 | -0.0561534 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0555964 |
| RAB7A | RAB7A, member RAS oncogene family | -0.054886 |
| COL5A1 | collagen, type V, alpha 1 | -0.0540458 |
| LMNA | lamin A/C | -0.0538949 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0530448 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0528951 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0527665 |
| MYADM | myeloid-associated differentiation marker | -0.0476782 |
| FOSL1 | FOS-like antigen 1 | -0.0465567 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0454816 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0443572 |
| TAGLN2 | transgelin 2 | -0.0439459 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0427949 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0427876 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0407615 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0405186 |
| VIM | vimentin | -0.0402354 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0400824 |
| PFN1 | profilin 1 | -0.0396857 |
| RND3 | Rho family GTPase 3 | -0.0395927 |
| GOLGA4 | golgin A4 | -0.0393057 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0380133 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.037797 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0374678 |
| SQSTM1 | sequestosome 1 | -0.036303 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0360144 |
| MSI2 | musashi RNA-binding protein 2 | -0.0357675 |
| PKM | pyruvate kinase, muscle | -0.0357208 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0355382 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -0.0353852 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.034826 |
| RPL35A | ribosomal protein L35a | -0.034525 |
| RTN4 | reticulon 4 | -0.0338696 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0337053 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0333732 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0332958 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0332565 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0326274 |
| ULK1 | unc-51 like autophagy activating kinase 1 | -0.0319913 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0318397 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0317054 |
| IL7R | interleukin 7 receptor | -0.0315889 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0313113 |
| FTL | ferritin, light polypeptide | -0.0298726 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0298123 |
| PLXNA2 | plexin A2 | -0.0292573 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.0291755 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0289109 |
| SUCNR1 | succinate receptor 1 | -0.0288819 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0288067 |
| CALR | calreticulin | -0.028778 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0285677 |
| JUN | jun proto-oncogene | -0.0281869 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0280974 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0280228 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0279045 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0278808 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0277216 |
| ADM | adrenomedullin | -0.0273836 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0272409 |
| MEIS2 | Meis homeobox 2 | -0.0267552 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0267093 |
| S100A11 | S100 calcium binding protein A11 | -0.0261342 |
| RIGI | RNA sensor RIG-I | -0.0261243 |
| SEPTIN7 | septin 7 | -0.0259051 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0256873 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.025534 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0251109 |
| EGR1 | early growth response 1 | -0.0250454 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0250076 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0248203 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0248107 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0244546 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0243223 |
