| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NHSL1 | NHS-like 1 | 0.0625104 |
| PDGFC | platelet derived growth factor C | 0.0503761 |
| YAP1 | Yes-associated protein 1 | 0.0501012 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0438326 |
| AHNAK | AHNAK nucleoprotein | 0.0432609 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0424663 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0412186 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0386343 |
| ACTG1 | actin gamma 1 | 0.0386298 |
| DST | dystonin | 0.0344243 |
| POTEF | POTE ankyrin domain family, member F | 0.0312968 |
| NLGN1 | neuroligin 1 | 0.0289586 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0284777 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0282022 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0278164 |
| PCBP2 | poly(rC) binding protein 2 | 0.0275194 |
| FSTL5 | follistatin-like 5 | 0.0263308 |
| SFPQ | splicing factor proline/glutamine-rich | 0.025519 |
| ENO1 | enolase 1, (alpha) | 0.0253349 |
| EHBP1 | EH domain binding protein 1 | 0.0237878 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0216034 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0213342 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0210304 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0206456 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0202973 |
| CLDND1 | claudin domain containing 1 | 0.0201298 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0195581 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0182494 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0179186 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0177659 |
| RPL3 | ribosomal protein L3 | 0.0167171 |
| EDARADD | EDAR-associated death domain | 0.0166801 |
| RASAL2 | RAS protein activator like 2 | 0.0161354 |
| FAT1 | FAT atypical cadherin 1 | 0.0160734 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.015711 |
| TENM3 | teneurin transmembrane protein 3 | 0.0157036 |
| RPL4 | ribosomal protein L4 | 0.0155072 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0153839 |
| RNF213 | ring finger protein 213 | 0.0153426 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 0.0150915 |
| DIAPH1 | diaphanous-related formin 1 | 0.0148658 |
| MCL1 | myeloid cell leukemia 1 | 0.0148531 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0138955 |
| ZNF407 | zinc finger protein 407 | 0.0136499 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0133861 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.013227 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0131149 |
| RAD51B | RAD51 paralog B | 0.0130651 |
| NAV3 | neuron navigator 3 | 0.0127386 |
| NOP2 | NOP2 nucleolar protein | 0.0125555 |
| KSR2 | kinase suppressor of ras 2 | 0.0124686 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0123129 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | 0.0120839 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0118696 |
| ECT2 | epithelial cell transforming 2 | 0.011837 |
| HMGA2 | high mobility group AT-hook 2 | 0.011785 |
| VCL | vinculin | 0.0116178 |
| FBL | fibrillarin | 0.0114675 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0114625 |
| UNC13A | unc-13 homolog A (C. elegans) | 0.011406 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0111771 |
| DCTN1 | dynactin 1 | 0.0110314 |
| CNTLN | centlein, centrosomal protein | 0.0110309 |
| KLHDC4 | kelch domain containing 4 | 0.0110248 |
| POLD2 | polymerase (DNA directed), delta 2, accessory subunit | 0.0110096 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0109477 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0109403 |
| IPO7 | importin 7 | 0.0108682 |
| ALMS1 | Alstrom syndrome protein 1 | 0.0108259 |
| TMEM267 | transmembrane protein 267 | 0.0108039 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0106353 |
| CEP112 | centrosomal protein 112kDa | 0.0106194 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0105925 |
| PARD3B | par-3 family cell polarity regulator beta | 0.010584 |
| CALR | calreticulin | 0.0103903 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0103091 |
| ANK2 | ankyrin 2, neuronal | 0.0102888 |
| ZNF618 | zinc finger protein 618 | 0.0100349 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.00996462 |
| AK2 | adenylate kinase 2 | 0.00995525 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0099457 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.00992822 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.00979654 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | 0.00974813 |
| KRT8 | keratin 8, type II | 0.00960154 |
| URI1 | URI1, prefoldin-like chaperone | 0.00951215 |
| DENND1B | DENN/MADD domain containing 1B | 0.00944824 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.00944256 |
| CNOT9 | CCR4-NOT transcription complex subunit 9 | 0.00931165 |
| FGF14 | fibroblast growth factor 14 | 0.00930626 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.00927622 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.00919587 |
| COL5A2 | collagen, type V, alpha 2 | 0.00913084 |
| CSMD1 | CUB and Sushi multiple domains 1 | 0.00911289 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.0090292 |
| DACH1 | dachshund family transcription factor 1 | 0.00901842 |
| PKM | pyruvate kinase, muscle | 0.00900633 |
| KIF18B | kinesin family member 18B | 0.00900325 |
| CEP43 | centrosomal protein 43 | 0.00895177 |
| AATF | apoptosis antagonizing transcription factor | 0.00892437 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.356338 |
| VIM | vimentin | -0.188708 |
| AREG | amphiregulin | -0.150827 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.139093 |
| TMSB10 | thymosin beta 10 | -0.118957 |
| FTL | ferritin, light polypeptide | -0.106166 |
| RPS2 | ribosomal protein S2 | -0.086816 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0830888 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0775165 |
| RPS6 | ribosomal protein S6 | -0.0762611 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0695317 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0676073 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.066659 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0626673 |
| TXNRD1 | thioredoxin reductase 1 | -0.0612732 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0612406 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.060154 |
| JMJD1C | jumonji domain containing 1C | -0.0560444 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0521106 |
| RPL19 | ribosomal protein L19 | -0.0500111 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0498729 |
| VMP1 | vacuole membrane protein 1 | -0.0493525 |
| H1-0 | H1.0 linker histone | -0.0492757 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0492635 |
| YBX3 | Y box binding protein 3 | -0.0490083 |
| CLTC | clathrin, heavy chain (Hc) | -0.046813 |
| CCND1 | cyclin D1 | -0.0466204 |
| MMP12 | matrix metallopeptidase 12 | -0.0464713 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.046186 |
| RPS8 | ribosomal protein S8 | -0.045402 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0439649 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0434638 |
| HMGA1 | high mobility group AT-hook 1 | -0.0429299 |
| RPL8 | ribosomal protein L8 | -0.0426051 |
| RPL38 | ribosomal protein L38 | -0.0424193 |
| RPL12 | ribosomal protein L12 | -0.0403388 |
| RPL11 | ribosomal protein L11 | -0.0399433 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0397134 |
| RPLP1 | ribosomal protein, large, P1 | -0.0391216 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0389149 |
| RPLP2 | ribosomal protein, large, P2 | -0.0388502 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0388198 |
| TPI1 | triosephosphate isomerase 1 | -0.0387473 |
| RTN4 | reticulon 4 | -0.038667 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0384255 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0382501 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0382279 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0378774 |
| TUBA1B | tubulin, alpha 1b | -0.0373651 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0373389 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0371915 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0371176 |
| VDAC1 | voltage-dependent anion channel 1 | -0.037086 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0369235 |
| RPL26 | ribosomal protein L26 | -0.0367685 |
| IL6ST | interleukin 6 signal transducer | -0.036673 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0365086 |
| HDLBP | high density lipoprotein binding protein | -0.0363936 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.036263 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.035965 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0357197 |
| PCDH7 | protocadherin 7 | -0.0356463 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0356359 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0355106 |
| MGAT4C | MGAT4 family, member C | -0.0351954 |
| RPS5 | ribosomal protein S5 | -0.0347123 |
| RPL34 | ribosomal protein L34 | -0.034471 |
| FBXO11 | F-box protein 11 | -0.0344653 |
| RPS19 | ribosomal protein S19 | -0.0344139 |
| RPS13 | ribosomal protein S13 | -0.0343669 |
| RPS16 | ribosomal protein S16 | -0.034197 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0341205 |
| SPAG9 | sperm associated antigen 9 | -0.0332704 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0332654 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0331495 |
| GOLGA4 | golgin A4 | -0.0331397 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0330558 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0330007 |
| SQSTM1 | sequestosome 1 | -0.0329428 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0328045 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0327655 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0327233 |
| SETD5 | SET domain containing 5 | -0.032523 |
| RPS29 | ribosomal protein S29 | -0.0323071 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0322648 |
| RPLP0 | ribosomal protein, large, P0 | -0.0322593 |
| RPS23 | ribosomal protein S23 | -0.0322088 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0320986 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0320785 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0320437 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0319249 |
| FUS | FUS RNA binding protein | -0.03189 |
| RPS24 | ribosomal protein S24 | -0.0314697 |
| RPL32 | ribosomal protein L32 | -0.031103 |
| EDN1 | endothelin 1 | -0.0307776 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0306238 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0303867 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | -0.0299993 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0298537 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0297735 |
