Ivabradine (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0790963
CCL2 chemokine (C-C motif) ligand 2 0.0640358
MYH9 myosin, heavy chain 9, non-muscle 0.0614133
ATP13A3 ATPase type 13A3 0.0563573
FTH1 ferritin, heavy polypeptide 1 0.0560351
CSF1 colony stimulating factor 1 (macrophage) 0.0525589
PTBP3 polypyrimidine tract binding protein 3 0.0519915
UGCG UDP-glucose ceramide glucosyltransferase 0.0472409
DENND2B DENN domain containing 2B 0.0460247
ANKRD33B ankyrin repeat domain 33B 0.042288
CADM1 cell adhesion molecule 1 0.0409159
WAC WW domain containing adaptor with coiled-coil 0.0407172
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0404126
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0403094
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0371915
ANKRD10 ankyrin repeat domain 10 0.0370069
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0366406
ANKRD11 ankyrin repeat domain 11 0.035164
MSN moesin 0.0349573
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0349451
ICAM1 intercellular adhesion molecule 1 0.034696
KMT2E lysine (K)-specific methyltransferase 2E 0.034096
WDR43 WD repeat domain 43 0.0336162
NRIP1 nuclear receptor interacting protein 1 0.0333801
GLS2 glutaminase 2 (liver, mitochondrial) 0.0330285
MARCHF6 membrane associated ring-CH-type finger 6 0.0324529
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0323392
G0S2 G0/G1 switch 2 0.0323348
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0318286
FLNA filamin A, alpha 0.0304637
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0298002
DDIT4 DNA-damage-inducible transcript 4 0.0297402
MYO10 myosin X 0.0292635
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.0286337
VCAM1 vascular cell adhesion molecule 1 0.0284225
POTEF POTE ankyrin domain family, member F 0.0281722
USP3 ubiquitin specific peptidase 3 0.0277736
RNF145 ring finger protein 145 0.0277456
COL4A1 collagen, type IV, alpha 1 0.0267029
ADAM17 ADAM metallopeptidase domain 17 0.0266676
SMAD3 SMAD family member 3 0.0260746
BHLHE40 basic helix-loop-helix family, member e40 0.0260139
RBM39 RNA binding motif protein 39 0.0256795
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0255981
SPAG9 sperm associated antigen 9 0.0255357
APP amyloid beta (A4) precursor protein 0.0254759
KMT2C lysine (K)-specific methyltransferase 2C 0.024905
LENG8 leukocyte receptor cluster (LRC) member 8 0.0245092
KDM6A lysine (K)-specific demethylase 6A 0.0244966
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0244869
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0241964
RPL3 ribosomal protein L3 0.0241831
PCBP2 poly(rC) binding protein 2 0.0240771
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0237865
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0237168
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0236381
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0236023
COL7A1 collagen, type VII, alpha 1 0.0235817
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0235513
ZFP36L1 ZFP36 ring finger protein-like 1 0.023289
QKI QKI, KH domain containing, RNA binding 0.023156
ZBTB10 zinc finger and BTB domain containing 10 0.0230335
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0228671
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0228031
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0227162
AZIN1 antizyme inhibitor 1 0.0223956
SRRT serrate, RNA effector molecule 0.02238
RBM33 RNA binding motif protein 33 0.0222382
AGFG1 ArfGAP with FG repeats 1 0.0221479
DENND5A DENN/MADD domain containing 5A 0.0221075
NAMPT nicotinamide phosphoribosyltransferase 0.0219932
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0219798
RAB8B RAB8B, member RAS oncogene family 0.0214617
TFG TRK-fused gene 0.0208697
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0206904
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0206741
TNIP1 TNFAIP3 interacting protein 1 0.0203993
TGFB2 transforming growth factor, beta 2 0.0203716
CXCL2 chemokine (C-X-C motif) ligand 2 0.020114
ITGAV integrin, alpha V 0.0199797
CUL3 cullin 3 0.0199137
OSBPL3 oxysterol binding protein-like 3 0.0198851
PTK2 protein tyrosine kinase 2 0.0198693
CXCL3 chemokine (C-X-C motif) ligand 3 0.0197907
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0197459
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0196833
CYB5R3 cytochrome b5 reductase 3 0.0196817
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0193994
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0193095
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0192828
ABI1 abl-interactor 1 0.0192341
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0192139
NAP1L1 nucleosome assembly protein 1-like 1 0.0191349
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0191334
SLMAP sarcolemma associated protein 0.0190711
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0188522
TRIO trio Rho guanine nucleotide exchange factor 0.0186558
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0184691
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0184393
YTHDC1 YTH domain containing 1 0.0184367

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.249283
FRMD4A FERM domain containing 4A -0.223495
VIM vimentin -0.163055
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.152784
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.149428
TMSB10 thymosin beta 10 -0.135638
ASPH aspartate beta-hydroxylase -0.121483
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.117456
GPC6 glypican 6 -0.117417
FTL ferritin, light polypeptide -0.108791
EXT1 exostosin glycosyltransferase 1 -0.108566
CD44 CD44 molecule (Indian blood group) -0.107636
HLA-B major histocompatibility complex, class I, B -0.0858503
TXNRD1 thioredoxin reductase 1 -0.0787252
RPS6 ribosomal protein S6 -0.0768067
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0702634
TPT1 tumor protein, translationally-controlled 1 -0.0653926
UBC ubiquitin C -0.0647788
B2M beta-2-microglobulin -0.0635108
MAP1B microtubule-associated protein 1B -0.0623671
RPL35A ribosomal protein L35a -0.05929
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0578681
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0570542
HM13 histocompatibility (minor) 13 -0.0562461
CTSD cathepsin D -0.0531381
SEC31A SEC31 homolog A (S. cerevisiae) -0.052626
ZBTB20 zinc finger and BTB domain containing 20 -0.0513657
HSPB1 heat shock 27kDa protein 1 -0.0513372
GOLGB1 golgin B1 -0.0509446
PDE4D phosphodiesterase 4D, cAMP-specific -0.0501455
RIGI RNA sensor RIG-I -0.0498349
RPL12 ribosomal protein L12 -0.0496458
CA12 carbonic anhydrase XII -0.0488576
PDIA3 protein disulfide isomerase family A, member 3 -0.0480035
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0475606
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0470548
BLZF1 basic leucine zipper nuclear factor 1 -0.0469136
SP100 SP100 nuclear antigen -0.0466689
RPS19 ribosomal protein S19 -0.046166
RPL8 ribosomal protein L8 -0.0460445
CANX calnexin -0.0456012
VCL vinculin -0.0455606
RPL34 ribosomal protein L34 -0.0454723
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0452665
RRBP1 ribosome binding protein 1 -0.0450468
CREB5 cAMP responsive element binding protein 5 -0.0442217
RPL19 ribosomal protein L19 -0.0441248
RPLP1 ribosomal protein, large, P1 -0.0437194
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0425927
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0422878
TFPI2 tissue factor pathway inhibitor 2 -0.041948
RPS5 ribosomal protein S5 -0.0417084
AKAP9 A kinase (PRKA) anchor protein 9 -0.0413637
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0410568
EGR1 early growth response 1 -0.0408357
RPS24 ribosomal protein S24 -0.040615
ANXA2 annexin A2 -0.0401036
CALU calumenin -0.0399375
IFI16 interferon, gamma-inducible protein 16 -0.0395196
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0385237
CALR calreticulin -0.0383767
CP ceruloplasmin (ferroxidase) -0.038362
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.038024
RPS4X ribosomal protein S4, X-linked -0.0379671
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0377892
MT2A metallothionein 2A -0.0376215
EHBP1 EH domain binding protein 1 -0.0374215
PFN1 profilin 1 -0.037346
SOD2 superoxide dismutase 2, mitochondrial -0.037228
NAV2 neuron navigator 2 -0.0371552
RNF213 ring finger protein 213 -0.0370598
RPL28 ribosomal protein L28 -0.0366944
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0365962
SDCBP syndecan binding protein (syntenin) -0.0359999
PRKCA protein kinase C, alpha -0.0359832
RAI14 retinoic acid induced 14 -0.0357179
TUBA1B tubulin, alpha 1b -0.0356912
MYADM myeloid-associated differentiation marker -0.0354114
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0352788
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0348495
BICD1 bicaudal D homolog 1 (Drosophila) -0.0347775
IFIH1 interferon induced with helicase C domain 1 -0.0345246
SETX senataxin -0.0344437
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0341984
RND3 Rho family GTPase 3 -0.0340806
S100A10 S100 calcium binding protein A10 -0.033955
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.033924
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0332835
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0332588
SPDYA speedy/RINGO cell cycle regulator family member A -0.033136
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0330731
RPL26 ribosomal protein L26 -0.0329436
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0326825
OSMR oncostatin M receptor -0.0324794
HDAC9 histone deacetylase 9 -0.032081
SCFD2 sec1 family domain containing 2 -0.0320298
IARS1 isoleucyl-tRNA synthetase 1 -0.0318258
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0318184
RAB7A RAB7A, member RAS oncogene family -0.0316575
PLIN2 perilipin 2 -0.0316427