| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MCL1 | myeloid cell leukemia 1 | 0.0856412 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.075443 |
| EFNA5 | ephrin-A5 | 0.0591855 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0449385 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0439557 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0417254 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0403285 |
| CMIP | c-Maf inducing protein | 0.0398168 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.038476 |
| ACTG1 | actin gamma 1 | 0.0357271 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0355005 |
| NAV2 | neuron navigator 2 | 0.0354124 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.034889 |
| RPL4 | ribosomal protein L4 | 0.0348182 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0336607 |
| SMAD3 | SMAD family member 3 | 0.0328464 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0282743 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0280857 |
| PRELID2 | PRELI domain containing 2 | 0.026663 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0264057 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | 0.0262186 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0259082 |
| FLNA | filamin A, alpha | 0.0258446 |
| C1D | C1D nuclear receptor corepressor | 0.0256257 |
| USP47 | ubiquitin specific peptidase 47 | 0.0247156 |
| GPATCH2L | G patch domain containing 2-like | 0.0244547 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.023664 |
| BTBD10 | BTB (POZ) domain containing 10 | 0.023375 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0230422 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0228237 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0226584 |
| MSN | moesin | 0.0223052 |
| POTEF | POTE ankyrin domain family, member F | 0.0222668 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0217316 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.0214125 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0213917 |
| RPL37A | ribosomal protein L37a | 0.0209826 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0207417 |
| BCL2L1 | BCL2-like 1 | 0.0206161 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0205773 |
| LAMC2 | laminin, gamma 2 | 0.0204579 |
| RPL3 | ribosomal protein L3 | 0.0198707 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0196508 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0196326 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0191072 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0190756 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0190238 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.018969 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0188969 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0187787 |
| PLEC | plectin | 0.0186771 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0184481 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0182692 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.018079 |
| TNS1 | tensin 1 | 0.0180373 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0179374 |
| LUZP1 | leucine zipper protein 1 | 0.017779 |
| CEP95 | centrosomal protein 95kDa | 0.0176773 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0175755 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0173803 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0173033 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0172033 |
| AXL | AXL receptor tyrosine kinase | 0.0171927 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0170676 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0169045 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0169034 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0168854 |
| SMYD3 | SET and MYND domain containing 3 | 0.0165476 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0162482 |
| LAMA5 | laminin, alpha 5 | 0.0161974 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0158835 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0157984 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0157692 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0157358 |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 0.0156673 |
| CDK19 | cyclin-dependent kinase 19 | 0.0153847 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0153283 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0153049 |
| FLNB | filamin B, beta | 0.0152999 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0150561 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0150262 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.014939 |
| R3HDM2 | R3H domain containing 2 | 0.0149359 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0148828 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0145245 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | 0.0144941 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0144194 |
| ACTN1 | actinin, alpha 1 | 0.0143984 |
| TUT7 | terminal uridylyl transferase 7 | 0.0143698 |
| TPM3 | tropomyosin 3 | 0.0141047 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.0138168 |
| RPS17 | ribosomal protein S17 | 0.0137956 |
| PMM2 | phosphomannomutase 2 | 0.0137882 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0136802 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0135754 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0135125 |
| VCL | vinculin | 0.0133116 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0133053 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.0132085 |
| URI1 | URI1, prefoldin-like chaperone | 0.0131966 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.377656 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.201686 |
| FTL | ferritin, light polypeptide | -0.198786 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.176607 |
| USP3 | ubiquitin specific peptidase 3 | -0.13549 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.132387 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.127912 |
| NDRG1 | N-myc downstream regulated 1 | -0.119928 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.116984 |
| RPS6 | ribosomal protein S6 | -0.114429 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.107488 |
| SPAG9 | sperm associated antigen 9 | -0.0848448 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0775068 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0761896 |
| UBC | ubiquitin C | -0.0743974 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0738148 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0734547 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0687979 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0672674 |
| PTMA | prothymosin, alpha | -0.0666099 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0655029 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0644084 |
| RPS19 | ribosomal protein S19 | -0.0639537 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0632176 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0624195 |
| CA12 | carbonic anhydrase XII | -0.0613926 |
| RPLP1 | ribosomal protein, large, P1 | -0.0610954 |
| KYNU | kynureninase | -0.0610553 |
| TKT | transketolase | -0.0603854 |
| PFN1 | profilin 1 | -0.0599181 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0595409 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0593383 |
| STC1 | stanniocalcin 1 | -0.0574767 |
| MT2A | metallothionein 2A | -0.0565576 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0560175 |
| HELZ | helicase with zinc finger | -0.0556743 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0554099 |
| RNF213 | ring finger protein 213 | -0.0553271 |
| RPLP0 | ribosomal protein, large, P0 | -0.0553251 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0515275 |
| PARD3 | par-3 family cell polarity regulator | -0.0501609 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0498663 |
| VIM | vimentin | -0.048448 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.047401 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0469268 |
| LDHA | lactate dehydrogenase A | -0.0466777 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0463508 |
| RPS5 | ribosomal protein S5 | -0.0462036 |
| IER3 | immediate early response 3 | -0.0456074 |
| TXNRD1 | thioredoxin reductase 1 | -0.0449768 |
| FAM13A | family with sequence similarity 13, member A | -0.0446612 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0441221 |
| RPL12 | ribosomal protein L12 | -0.0432068 |
| DENND4C | DENN/MADD domain containing 4C | -0.0428234 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0427637 |
| RPL19 | ribosomal protein L19 | -0.0422551 |
| MT1X | metallothionein 1X | -0.0421034 |
| S100A10 | S100 calcium binding protein A10 | -0.0417037 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0414894 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0412587 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0409646 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0408433 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0407635 |
| ANXA2 | annexin A2 | -0.040164 |
| PTK2 | protein tyrosine kinase 2 | -0.039969 |
| RPS16 | ribosomal protein S16 | -0.0398975 |
| WDR45B | WD repeat domain 45B | -0.0394573 |
| KCMF1 | potassium channel modulatory factor 1 | -0.039406 |
| NUP58 | nucleoporin 58 | -0.0392992 |
| GOLGA4 | golgin A4 | -0.0385954 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0380784 |
| MYO1B | myosin IB | -0.0378149 |
| RPS23 | ribosomal protein S23 | -0.0377216 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0374841 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.037245 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0372261 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0370856 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0370459 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0364206 |
| RAI14 | retinoic acid induced 14 | -0.0363743 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0362988 |
| LOC112694756 | uncharaterized LOC112694756 | -0.036207 |
| RPS24 | ribosomal protein S24 | -0.0361885 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0361651 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0359379 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0357952 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0356469 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0348929 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0345457 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0344379 |
| FMNL2 | formin-like 2 | -0.0341938 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0340443 |
| PDE10A | phosphodiesterase 10A | -0.0339916 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.033916 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0339125 |
| RPS13 | ribosomal protein S13 | -0.0338299 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0337884 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0337866 |
| H1-0 | H1.0 linker histone | -0.0331399 |
| CLINT1 | clathrin interactor 1 | -0.0329811 |
