| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEST | mesoderm specific transcript | 0.185626 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.125 |
| PTMA | prothymosin, alpha | 0.0927278 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0763198 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.060989 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0544079 |
| CALR | calreticulin | 0.051142 |
| RPS2 | ribosomal protein S2 | 0.0481619 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0478802 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0474292 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0471751 |
| RPL3 | ribosomal protein L3 | 0.0458754 |
| VEGFA | vascular endothelial growth factor A | 0.0450406 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0441179 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0424429 |
| RPS12 | ribosomal protein S12 | 0.0422583 |
| YBX1 | Y box binding protein 1 | 0.041786 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0406974 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0400566 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0390282 |
| ENO1 | enolase 1, (alpha) | 0.0383807 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0375112 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0366927 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0366254 |
| MED13L | mediator complex subunit 13-like | 0.0357287 |
| CANX | calnexin | 0.034664 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.033418 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0328767 |
| YAP1 | Yes-associated protein 1 | 0.0324542 |
| APP | amyloid beta (A4) precursor protein | 0.0308783 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0308712 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0307487 |
| ITGAV | integrin, alpha V | 0.0303076 |
| TMSB4X | thymosin beta 4, X-linked | 0.0300324 |
| MATR3 | matrin 3 | 0.0293998 |
| TPM3 | tropomyosin 3 | 0.0292436 |
| AHNAK | AHNAK nucleoprotein | 0.0291625 |
| FTL | ferritin, light polypeptide | 0.0288213 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0285488 |
| FMNL2 | formin-like 2 | 0.0279842 |
| RBM39 | RNA binding motif protein 39 | 0.0278362 |
| CABIN1 | calcineurin binding protein 1 | 0.0275856 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0274313 |
| WDR45B | WD repeat domain 45B | 0.0271905 |
| RPS3 | ribosomal protein S3 | 0.0264958 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0262505 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.026033 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0258481 |
| EZR | ezrin | 0.0257792 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0255421 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0251284 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0249824 |
| RPL4 | ribosomal protein L4 | 0.0247588 |
| PEX3 | peroxisomal biogenesis factor 3 | 0.0245474 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0242968 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0241441 |
| NFYA | nuclear transcription factor Y, alpha | 0.0239722 |
| SET | SET nuclear proto-oncogene | 0.0238566 |
| CHD3 | chromodomain helicase DNA binding protein 3 | 0.02354 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0232189 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0231836 |
| RPL37A | ribosomal protein L37a | 0.0231227 |
| POTEF | POTE ankyrin domain family, member F | 0.0229954 |
| DST | dystonin | 0.0229698 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0229351 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0225808 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0224717 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0224534 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0223741 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.022199 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0221016 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0220926 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0220745 |
| DENR | density-regulated protein | 0.0219925 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0217335 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.0216957 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0216573 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0216417 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0216291 |
| YTHDC1 | YTH domain containing 1 | 0.0212354 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.021225 |
| RPS7 | ribosomal protein S7 | 0.021167 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0209937 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.020906 |
| HLTF | helicase-like transcription factor | 0.0208842 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.0205026 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.020389 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0203824 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0201677 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0200827 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0200214 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.0199453 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0199236 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0198896 |
| FBL | fibrillarin | 0.0197124 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0194952 |
| PDS5B | PDS5 cohesin associated factor B | 0.0194271 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0194074 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0193255 |
| GTF3C3 | general transcription factor IIIC, polypeptide 3, 102kDa | 0.0192903 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.186855 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.182833 |
| HMGA2 | high mobility group AT-hook 2 | -0.0899057 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.089859 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0873332 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.0786026 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0677563 |
| PEG10 | paternally expressed 10 | -0.0649833 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0648055 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0610342 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0577985 |
| TUBB | tubulin, beta class I | -0.0574937 |
| PDE10A | phosphodiesterase 10A | -0.0573225 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0572468 |
| MEOX2 | mesenchyme homeobox 2 | -0.0488433 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0485293 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0485129 |
| ERBIN | erbb2 interacting protein | -0.0483559 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0477408 |
| FN1 | fibronectin 1 | -0.0473285 |
| PTK2 | protein tyrosine kinase 2 | -0.0461053 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0441007 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0435231 |
| CUX1 | cut-like homeobox 1 | -0.0433816 |
| RPS6 | ribosomal protein S6 | -0.0433556 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0431787 |
| EXOC4 | exocyst complex component 4 | -0.042739 |
| VIM | vimentin | -0.0425113 |
| TCF12 | transcription factor 12 | -0.0424723 |
| GPHN | gephyrin | -0.0420702 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0420477 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0406507 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0401101 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0400185 |
| HMGA1 | high mobility group AT-hook 1 | -0.0399751 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0390833 |
| SBF2 | SET binding factor 2 | -0.0387752 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0387165 |
| RANBP17 | RAN binding protein 17 | -0.0375755 |
| DIAPH3 | diaphanous-related formin 3 | -0.0373032 |
| RAD51B | RAD51 paralog B | -0.0369805 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0368908 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0361681 |
| PHIP | pleckstrin homology domain interacting protein | -0.0358224 |
| TULP4 | tubby like protein 4 | -0.0353732 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0349554 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0347479 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0344021 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0340826 |
| HDAC8 | histone deacetylase 8 | -0.0336891 |
| MAP1B | microtubule-associated protein 1B | -0.0336536 |
| SPAG9 | sperm associated antigen 9 | -0.0336332 |
| EGFR | epidermal growth factor receptor | -0.0335458 |
| IER3 | immediate early response 3 | -0.0332766 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0328417 |
| FUS | FUS RNA binding protein | -0.0328356 |
| HMGB1 | high mobility group box 1 | -0.0328002 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0327644 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0327449 |
| FNIP1 | folliculin interacting protein 1 | -0.0325634 |
| NFIA | nuclear factor I/A | -0.032472 |
| RPS24 | ribosomal protein S24 | -0.0323662 |
| KLHL24 | kelch-like family member 24 | -0.0320026 |
| SMYD3 | SET and MYND domain containing 3 | -0.0317039 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0316357 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0315465 |
| SEPTIN11 | septin 11 | -0.0308326 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0305836 |
| PDE8A | phosphodiesterase 8A | -0.0304864 |
| CCNI | cyclin I | -0.0304772 |
| ZNF609 | zinc finger protein 609 | -0.0303378 |
| GPC6 | glypican 6 | -0.0300472 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0300368 |
| GMPS | guanine monphosphate synthase | -0.0292008 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0290812 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0290285 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0289126 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0287039 |
| FAM193A | family with sequence similarity 193, member A | -0.0284262 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0279666 |
| ATF6 | activating transcription factor 6 | -0.0279208 |
| BPTF | bromodomain PHD finger transcription factor | -0.0278598 |
| ZFHX3 | zinc finger homeobox 3 | -0.0271042 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | -0.0270612 |
| MT2A | metallothionein 2A | -0.0268669 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0268107 |
| RLF | rearranged L-myc fusion | -0.0266913 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0262503 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0261514 |
| GOLGA4 | golgin A4 | -0.0260226 |
| POM121C | POM121 transmembrane nucleoporin C | -0.0257548 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0257372 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0256488 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0256459 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0254214 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | -0.0254131 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0253135 |
| MIPOL1 | mirror-image polydactyly 1 | -0.0252956 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0252753 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0252347 |
