| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | 0.0916041 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0826355 |
| FLNB | filamin B, beta | 0.072631 |
| PLEC | plectin | 0.0610629 |
| GRB10 | growth factor receptor-bound protein 10 | 0.050123 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.040246 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0395099 |
| SMAD3 | SMAD family member 3 | 0.0375928 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0370338 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0354897 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0348276 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0337651 |
| LMTK2 | lemur tyrosine kinase 2 | 0.032365 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0287653 |
| SDC4 | syndecan 4 | 0.0284805 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0280899 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0271314 |
| OGA | O-GlcNAcase | 0.0261901 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0252589 |
| RPS2 | ribosomal protein S2 | 0.0246807 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0241362 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0236769 |
| NPTN | neuroplastin | 0.0233979 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0232357 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0231815 |
| TUFT1 | tuftelin 1 | 0.0229185 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0226736 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0224327 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0219551 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.021945 |
| CORO1C | coronin, actin binding protein, 1C | 0.0214444 |
| APP | amyloid beta (A4) precursor protein | 0.0212994 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0212603 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0203483 |
| NEK7 | NIMA-related kinase 7 | 0.0202255 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0200726 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0197128 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0196054 |
| ITGA6 | integrin, alpha 6 | 0.0195376 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0194516 |
| NIBAN2 | niban apoptosis regulator 2 | 0.019106 |
| AFDN | afadin, adherens junction formation factor | 0.0189088 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0186222 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0180917 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.017839 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0175191 |
| RASA3 | RAS p21 protein activator 3 | 0.0173963 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0173392 |
| IPO7 | importin 7 | 0.0172538 |
| YAP1 | Yes-associated protein 1 | 0.0172023 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0170703 |
| RPL4 | ribosomal protein L4 | 0.0170305 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0168498 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0166883 |
| CDHR2 | cadherin-related family member 2 | 0.0166736 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0165784 |
| PTK2B | protein tyrosine kinase 2 beta | 0.0164937 |
| CAPRIN2 | caprin family member 2 | 0.0164859 |
| DSPP | dentin sialophosphoprotein | 0.0164169 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0163007 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0162401 |
| FAM13A | family with sequence similarity 13, member A | 0.0162305 |
| RPS7 | ribosomal protein S7 | 0.0161029 |
| RPL3 | ribosomal protein L3 | 0.0158667 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0157662 |
| RPS12 | ribosomal protein S12 | 0.0157013 |
| FOXO1 | forkhead box O1 | 0.0149785 |
| ABI1 | abl-interactor 1 | 0.0148824 |
| MNMIP1 | manchette microtubule inner protein 1 | 0.014647 |
| YBX1 | Y box binding protein 1 | 0.0146389 |
| CSNK1G3 | casein kinase 1, gamma 3 | 0.0144893 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0143105 |
| SPOPL | speckle-type POZ protein-like | 0.0141151 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0140905 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0139287 |
| OSBP2 | oxysterol binding protein 2 | 0.0137178 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0136885 |
| HPCAL1 | hippocalcin-like 1 | 0.0135918 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0133589 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0132353 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.0130773 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0130128 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0129786 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0129426 |
| MCL1 | myeloid cell leukemia 1 | 0.0128898 |
| FMNL2 | formin-like 2 | 0.0128637 |
| ATP13A3 | ATPase type 13A3 | 0.0128091 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.0127985 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0126831 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0124874 |
| HAPSTR1 | HUWE1 associated protein modifying stress responses | 0.0124571 |
| GPX4 | glutathione peroxidase 4 | 0.0124389 |
| CAB39 | calcium binding protein 39 | 0.0123718 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0123349 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0122045 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0121788 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0121236 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0120013 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0119706 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0118851 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.192314 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.130739 |
| HMGA1 | high mobility group AT-hook 1 | -0.129997 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.111388 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.10773 |
| TMSB10 | thymosin beta 10 | -0.101394 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.100663 |
| MUC17 | mucin 17, cell surface associated | -0.0937958 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0923607 |
| VIM | vimentin | -0.0882438 |
| EGFR | epidermal growth factor receptor | -0.0855633 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | -0.0805321 |
| LDHA | lactate dehydrogenase A | -0.0776598 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0757754 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0754391 |
| EGR1 | early growth response 1 | -0.0751917 |
| S100A10 | S100 calcium binding protein A10 | -0.0729456 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.0724099 |
| LAMA4 | laminin, alpha 4 | -0.0721274 |
| MXD1 | MAX dimerization protein 1 | -0.0678166 |
| TXNRD1 | thioredoxin reductase 1 | -0.066864 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0666768 |
| UBC | ubiquitin C | -0.0635859 |
| RIOK3 | RIO kinase 3 | -0.0633976 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0631831 |
| EMP1 | epithelial membrane protein 1 | -0.0629372 |
| PGK1 | phosphoglycerate kinase 1 | -0.0623778 |
| LMO7 | LIM domain 7 | -0.0616326 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0610277 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.060199 |
| NDRG1 | N-myc downstream regulated 1 | -0.0581943 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0576584 |
| S100A6 | S100 calcium binding protein A6 | -0.0560678 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0546505 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0543674 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0537571 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0532745 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0532593 |
| PERP | PERP, TP53 apoptosis effector | -0.0530472 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.052011 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0516477 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0482101 |
| ANXA2 | annexin A2 | -0.0473732 |
| TRRAP | transformation/transcription domain-associated protein | -0.0466178 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0448037 |
| ARF4 | ADP-ribosylation factor 4 | -0.0437563 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0434992 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0432792 |
| RPS6 | ribosomal protein S6 | -0.0429178 |
| PTMA | prothymosin, alpha | -0.0429153 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0420604 |
| KRT19 | keratin 19, type I | -0.0420233 |
| POTEF | POTE ankyrin domain family, member F | -0.0419542 |
| RPL35A | ribosomal protein L35a | -0.0407406 |
| GOLGA4 | golgin A4 | -0.0404535 |
| S100A4 | S100 calcium binding protein A4 | -0.0400734 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0394206 |
| S100A11 | S100 calcium binding protein A11 | -0.0393625 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0393107 |
| MORF4L2 | mortality factor 4 like 2 | -0.0391797 |
| PFN1 | profilin 1 | -0.0384837 |
| WASF2 | WAS protein family, member 2 | -0.0381341 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0378141 |
| TAOK3 | TAO kinase 3 | -0.0377975 |
| DSG2 | desmoglein 2 | -0.0376149 |
| NPSR1 | neuropeptide S receptor 1 | -0.0375065 |
| RPL8 | ribosomal protein L8 | -0.037082 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0367155 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0366922 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0366739 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0364515 |
| CALU | calumenin | -0.0362174 |
| CD2AP | CD2-associated protein | -0.0360652 |
| TXNIP | thioredoxin interacting protein | -0.0360059 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0358632 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0353434 |
| KLK10 | kallikrein-related peptidase 10 | -0.035208 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0351764 |
| NBEAL1 | neurobeachin-like 1 | -0.0349946 |
| FBXO11 | F-box protein 11 | -0.0342669 |
| THOC2 | THO complex 2 | -0.0342227 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.033847 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0332024 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.033195 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0330976 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0324347 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.031995 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0319927 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.03195 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0317573 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0311801 |
| ERBIN | erbb2 interacting protein | -0.0304896 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0304784 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0302749 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0298597 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.029721 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0296655 |
| KCMF1 | potassium channel modulatory factor 1 | -0.02961 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0294612 |
| RASAL2 | RAS protein activator like 2 | -0.0293833 |
