| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VMP1 | vacuole membrane protein 1 | 0.110887 |
| RPL23 | ribosomal protein L23 | 0.109551 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.106112 |
| NDRG1 | N-myc downstream regulated 1 | 0.0869059 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0796597 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.0615867 |
| ENO1 | enolase 1, (alpha) | 0.0535499 |
| MCL1 | myeloid cell leukemia 1 | 0.052838 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0507053 |
| TSC22D2 | TSC22 domain family, member 2 | 0.049455 |
| ACTG1 | actin gamma 1 | 0.0469615 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0456303 |
| SET | SET nuclear proto-oncogene | 0.043553 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0433926 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0410707 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0397031 |
| TOM1L1 | target of myb1 (chicken)-like 1 | 0.0394383 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0379778 |
| RPS3 | ribosomal protein S3 | 0.037922 |
| CEP250 | centrosomal protein 250kDa | 0.0373838 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0364352 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.035375 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0348633 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0348126 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0334963 |
| TMEM165 | transmembrane protein 165 | 0.0327255 |
| RPL19 | ribosomal protein L19 | 0.0323334 |
| PRELID2 | PRELI domain containing 2 | 0.0322738 |
| PTMA | prothymosin, alpha | 0.0322609 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0321339 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0320061 |
| VEGFA | vascular endothelial growth factor A | 0.0319193 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0315701 |
| TOP6BL | TOP6B like initiator of meiotic double strand breaks | 0.0306897 |
| AHNAK | AHNAK nucleoprotein | 0.0305983 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0303823 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0296962 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0288257 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0287161 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0286789 |
| DSPP | dentin sialophosphoprotein | 0.0286651 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0285833 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0285649 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0282422 |
| APP | amyloid beta (A4) precursor protein | 0.0280433 |
| RAD51B | RAD51 paralog B | 0.0278101 |
| POTEF | POTE ankyrin domain family, member F | 0.0274318 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0268229 |
| FAM13A | family with sequence similarity 13, member A | 0.0262746 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0258761 |
| YAP1 | Yes-associated protein 1 | 0.0258442 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.025713 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0255794 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0255503 |
| TPD52 | tumor protein D52 | 0.025322 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0251281 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.025117 |
| PCBP2 | poly(rC) binding protein 2 | 0.0246337 |
| TPM3 | tropomyosin 3 | 0.0245296 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0241695 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0236156 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0234763 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0234467 |
| BBX | bobby sox homolog (Drosophila) | 0.0233694 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0227973 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0227904 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0226963 |
| ZNF292 | zinc finger protein 292 | 0.022679 |
| FBXO32 | F-box protein 32 | 0.0226164 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0224479 |
| ASPH | aspartate beta-hydroxylase | 0.0223915 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0221448 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0220405 |
| CCNY | cyclin Y | 0.0220018 |
| YEATS2 | YEATS domain containing 2 | 0.021973 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0219042 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0218099 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0216493 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0210112 |
| FLNB | filamin B, beta | 0.02095 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | 0.0207593 |
| RPL3 | ribosomal protein L3 | 0.0206103 |
| RPS12 | ribosomal protein S12 | 0.0204932 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0204456 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0203623 |
| FOXO3 | forkhead box O3 | 0.0202972 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0193451 |
| SBF2 | SET binding factor 2 | 0.0192748 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0191206 |
| IPO7 | importin 7 | 0.0190672 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0189242 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0180583 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 0.0179944 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0179379 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.0179053 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0178878 |
| USP53 | ubiquitin specific peptidase 53 | 0.0178564 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0178405 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0178037 |
| TMEM45B | transmembrane protein 45B | 0.0176854 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CATSPERB | catsper channel auxiliary subunit beta | -0.0708971 |
| CDK12 | cyclin-dependent kinase 12 | -0.0685142 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0663949 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0515058 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.0483799 |
| CCND1 | cyclin D1 | -0.0475346 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0445604 |
| NTN4 | netrin 4 | -0.0431346 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0406541 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0366056 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.035297 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0333201 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0330375 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0269119 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0264977 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0246763 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0243082 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0232873 |
| KAZN | kazrin, periplakin interacting protein | -0.0227469 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0219043 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0215728 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0214019 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0213764 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0211917 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0207364 |
| INSR | insulin receptor | -0.0206439 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.019802 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0196491 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0194244 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0194153 |
| GLCCI1 | glucocorticoid induced 1 | -0.0193482 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0188718 |
| TNS3 | tensin 3 | -0.018201 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0181601 |
| MED13L | mediator complex subunit 13-like | -0.017986 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0176742 |
| RAB1B | RAB1B, member RAS oncogene family | -0.0173025 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0172916 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.017078 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.016967 |
| TTC6 | tetratricopeptide repeat domain 6 | -0.0165885 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0163632 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0161738 |
| OLA1 | Obg-like ATPase 1 | -0.0159248 |
| HLA-C | major histocompatibility complex, class I, C | -0.0157419 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0155949 |
| HMGB1 | high mobility group box 1 | -0.015468 |
| NF1 | neurofibromin 1 | -0.0153217 |
| INTS6 | integrator complex subunit 6 | -0.0152916 |
| ATF6 | activating transcription factor 6 | -0.0152771 |
| DUSP16 | dual specificity phosphatase 16 | -0.0148558 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0147017 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0145839 |
| NRP1 | neuropilin 1 | -0.0145186 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0144093 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0143636 |
| GPC5 | glypican 5 | -0.0142691 |
| NRCAM | neuronal cell adhesion molecule | -0.0142585 |
| FNDC3B | fibronectin type III domain containing 3B | -0.014234 |
| SYNRG | synergin, gamma | -0.0141085 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0138128 |
| AGR2 | anterior gradient 2 | -0.0136913 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0135135 |
| H1-0 | H1.0 linker histone | -0.0135044 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0133986 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0132134 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0131913 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0131368 |
| CUX1 | cut-like homeobox 1 | -0.0131068 |
| S100A9 | S100 calcium binding protein A9 | -0.0129942 |
| PLCB4 | phospholipase C, beta 4 | -0.0129734 |
| SPTSSB | serine palmitoyltransferase, small subunit B | -0.0129486 |
| S100A8 | S100 calcium binding protein A8 | -0.0129436 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0129361 |
| TP53INP2 | tumor protein p53 inducible nuclear protein 2 | -0.012797 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0126046 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0124311 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0124299 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0123528 |
| RPL34 | ribosomal protein L34 | -0.0123151 |
| FASN | fatty acid synthase | -0.0123087 |
| RPS24 | ribosomal protein S24 | -0.0123067 |
| GALNT10 | polypeptide N-acetylgalactosaminyltransferase 10 | -0.0122962 |
| RPL35A | ribosomal protein L35a | -0.0122811 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0122269 |
| ANKRD30A | ankyrin repeat domain 30A | -0.012166 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0121411 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0121052 |
| OSMR | oncostatin M receptor | -0.0118622 |
| STXBP4 | syntaxin binding protein 4 | -0.0118611 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0118569 |
| XBP1 | X-box binding protein 1 | -0.0118421 |
| SMIM14 | small integral membrane protein 14 | -0.0118188 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0118149 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0116078 |
| SEPTIN11 | septin 11 | -0.0115756 |
| TRIM37 | tripartite motif containing 37 | -0.0115049 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0114473 |
| IER3 | immediate early response 3 | -0.0112682 |
| TOX3 | TOX high mobility group box family member 3 | -0.0112059 |
