Ivabradine (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.087955
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0633882
STAT1 signal transducer and activator of transcription 1, 91kDa 0.062551
RPL4 ribosomal protein L4 0.0606643
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0599104
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0596488
RPS3 ribosomal protein S3 0.0587717
KIAA1958 KIAA1958 0.0581431
NGLY1 N-glycanase 1 0.0558427
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0549179
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0515064
SLF1 SMC5-SMC6 complex localization factor 1 0.0512161
NFIA nuclear factor I/A 0.0495422
RPL3 ribosomal protein L3 0.0485159
RPS12 ribosomal protein S12 0.0479166
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0474678
RBM25 RNA binding motif protein 25 0.0453442
GYS1 glycogen synthase 1 (muscle) 0.0443809
YEATS2 YEATS domain containing 2 0.0438454
SOX2 SRY (sex determining region Y)-box 2 0.0436418
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0434009
ZNF292 zinc finger protein 292 0.0427239
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0394357
JMJD1C jumonji domain containing 1C 0.0385567
EIF4A1 eukaryotic translation initiation factor 4A1 0.0382812
CCNY cyclin Y 0.0382112
OGA O-GlcNAcase 0.037608
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0370651
TOP2B topoisomerase (DNA) II beta 180kDa 0.0370046
CCDC47 coiled-coil domain containing 47 0.0366982
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0366976
ENO1 enolase 1, (alpha) 0.0359454
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0358161
SET SET nuclear proto-oncogene 0.035438
KDM1A lysine (K)-specific demethylase 1A 0.0353623
PTCH1 patched 1 0.0353515
EIF4B eukaryotic translation initiation factor 4B 0.0353367
ARB2A ARB2 cotranscriptional regulator A 0.0347288
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0346958
RPL37A ribosomal protein L37a 0.0341244
RPL5 ribosomal protein L5 0.0332902
ZFP36L1 ZFP36 ring finger protein-like 1 0.0332635
EFNA5 ephrin-A5 0.0331609
FAM162A family with sequence similarity 162, member A 0.0330875
MXI1 MAX interactor 1, dimerization protein 0.032188
EEF2 eukaryotic translation elongation factor 2 0.0319224
NEK7 NIMA-related kinase 7 0.0313315
ARHGAP5 Rho GTPase activating protein 5 0.031308
RTN4 reticulon 4 0.0308434
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0306347
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0304001
EPN2 epsin 2 0.0301084
SMAP1 small ArfGAP 1 0.0300851
MIMS1 mitochondrial inner membrane scaffold 1 0.0298381
AFDN afadin, adherens junction formation factor 0.0297931
DIDO1 death inducer-obliterator 1 0.0296604
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0295317
HSPA8 heat shock 70kDa protein 8 0.0292125
ATRN attractin 0.0291297
FAM13A family with sequence similarity 13, member A 0.0287428
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0280092
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0279516
RPL23 ribosomal protein L23 0.027319
CHD7 chromodomain helicase DNA binding protein 7 0.0270159
ZNF608 zinc finger protein 608 0.0269948
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.026932
RPS17 ribosomal protein S17 0.0268896
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0267001
B2M beta-2-microglobulin 0.0266591
PRELID2 PRELI domain containing 2 0.0266402
NAMPT nicotinamide phosphoribosyltransferase 0.0266015
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0262517
FMNL2 formin-like 2 0.0262002
GJA1 gap junction protein, alpha 1, 43kDa 0.0260644
RLF rearranged L-myc fusion 0.0259702
MCL1 myeloid cell leukemia 1 0.025795
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 0.0255714
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0255658
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0255119
VMP1 vacuole membrane protein 1 0.0254195
UCK2 uridine-cytidine kinase 2 0.0254191
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0253859
PGAM4 phosphoglycerate mutase family member 4 0.0253674
INSIG2 insulin induced gene 2 0.0253645
SRSF4 serine/arginine-rich splicing factor 4 0.0253218
DPYSL2 dihydropyrimidinase-like 2 0.0253181
MEF2A myocyte enhancer factor 2A 0.0252373
ADAR adenosine deaminase, RNA-specific 0.0252257
RPS8 ribosomal protein S8 0.0251659
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0250581
LRRC1 leucine rich repeat containing 1 0.0250226
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0249828
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0249229
MED13L mediator complex subunit 13-like 0.0249088
SPRED1 sprouty-related, EVH1 domain containing 1 0.02469
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0245514
IPO7 importin 7 0.024464
AK4 adenylate kinase 4 0.0244412
RBM39 RNA binding motif protein 39 0.0242716
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0240993

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.237551
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.181651
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.126323
SLIT2 slit homolog 2 (Drosophila) -0.126064
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.103104
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.090265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0857226
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0840559
TENM3 teneurin transmembrane protein 3 -0.0764161
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0634405
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0617223
ARHGAP32 Rho GTPase activating protein 32 -0.0606696
ADGRG6 adhesion G protein-coupled receptor G6 -0.0551511
HMGA1 high mobility group AT-hook 1 -0.0532152
RAD51B RAD51 paralog B -0.0521168
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0508167
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0455206
FUS FUS RNA binding protein -0.0452981
CELF2 CUGBP, Elav-like family member 2 -0.0446133
PDIA3 protein disulfide isomerase family A, member 3 -0.0439983
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.043875
TBC1D32 TBC1 domain family, member 32 -0.0416766
HMGB1 high mobility group box 1 -0.0409717
CADM2 cell adhesion molecule 2 -0.038328
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0379229
ACTG1 actin gamma 1 -0.0368231
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0367863
MLIP muscular LMNA-interacting protein -0.0358132
IARS1 isoleucyl-tRNA synthetase 1 -0.0339096
CENPF centromere protein F, 350/400kDa -0.0330859
PRICKLE1 prickle homolog 1 (Drosophila) -0.0328411
TOM1L2 target of myb1-like 2 (chicken) -0.0321837
DENND1A DENN/MADD domain containing 1A -0.0321103
ZNF644 zinc finger protein 644 -0.0319948
PFN1 profilin 1 -0.0317942
VDAC1 voltage-dependent anion channel 1 -0.0316327
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0314732
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0313622
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0313329
CDH18 cadherin 18, type 2 -0.0310433
ZCCHC7 zinc finger, CCHC domain containing 7 -0.030932
SETX senataxin -0.0306146
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0304228
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0303911
EEF1G eukaryotic translation elongation factor 1 gamma -0.0299101
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0296789
NEBL nebulette -0.0296603
WLS wntless Wnt ligand secretion mediator -0.029528
RPS21 ribosomal protein S21 -0.0293447
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.02883
CCSER1 coiled-coil serine-rich protein 1 -0.028377
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0278831
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0278662
SLC38A2 solute carrier family 38, member 2 -0.0277012
CCAR1 cell division cycle and apoptosis regulator 1 -0.0271466
BCAS3 breast carcinoma amplified sequence 3 -0.026274
WDR27 WD repeat domain 27 -0.0260295
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0258515
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0256933
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0255742
DIAPH2 diaphanous-related formin 2 -0.0247561
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0247053
EXOC4 exocyst complex component 4 -0.0247052
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0246229
ATF6 activating transcription factor 6 -0.0246109
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0243377
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0243218
INTS6 integrator complex subunit 6 -0.024286
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0239674
RPL8 ribosomal protein L8 -0.0237404
RPS15 ribosomal protein S15 -0.0237329
RRM2 ribonucleotide reductase M2 -0.0236261
MKI67 marker of proliferation Ki-67 -0.0235945
SMC4 structural maintenance of chromosomes 4 -0.0235586
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0235444
ATP5F1B ATP synthase F1 subunit beta -0.0235079
UBAP2 ubiquitin associated protein 2 -0.0233034
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0230437
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0229613
GNAS GNAS complex locus -0.0227795
TRAF3 TNF receptor-associated factor 3 -0.0225641
BABAM2 BRISC and BRCA1 A complex member 2 -0.0222846
ACBD6 acyl-CoA binding domain containing 6 -0.0222663
SPDYA speedy/RINGO cell cycle regulator family member A -0.02225
SALL4 spalt-like transcription factor 4 -0.0220904
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.021972
IGF2 insulin-like growth factor 2 -0.0218185
INO80 INO80 complex subunit -0.0218001
PCNX4 pecanex 4 -0.0218
ZNF407 zinc finger protein 407 -0.0217005
RPL28 ribosomal protein L28 -0.0216225
RSF1 remodeling and spacing factor 1 -0.021538
TRAPPC9 trafficking protein particle complex 9 -0.0215187
E2F3 E2F transcription factor 3 -0.0212638
PRH1 proline-rich protein HaeIII subfamily 1 -0.0212387
ZNF609 zinc finger protein 609 -0.02121
SRSF3 serine/arginine-rich splicing factor 3 -0.0210594
TRRAP transformation/transcription domain-associated protein -0.0207608
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0207037
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0207023