| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0901326 |
| ENO1 | enolase 1, (alpha) | 0.0800927 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0769561 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0745324 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0717364 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.071513 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0684117 |
| CDC73 | cell division cycle 73 | 0.0570828 |
| VGF | VGF nerve growth factor inducible | 0.055924 |
| FMNL2 | formin-like 2 | 0.051988 |
| PRELID2 | PRELI domain containing 2 | 0.0495072 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0484536 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0476671 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.046688 |
| AHNAK | AHNAK nucleoprotein | 0.0441273 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0421054 |
| ASPH | aspartate beta-hydroxylase | 0.0417342 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.041681 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0411288 |
| TMEM178B | transmembrane protein 178B | 0.0407877 |
| PTMA | prothymosin, alpha | 0.0405966 |
| FBXO7 | F-box protein 7 | 0.0400753 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0391057 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.0386476 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.038126 |
| APP | amyloid beta (A4) precursor protein | 0.0362742 |
| ZNF292 | zinc finger protein 292 | 0.0340042 |
| TPR | translocated promoter region, nuclear basket protein | 0.033375 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0331886 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0325337 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0317742 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0315615 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0313583 |
| CENPF | centromere protein F, 350/400kDa | 0.0310388 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0309408 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0308914 |
| OGA | O-GlcNAcase | 0.0306934 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0301924 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.029751 |
| VIM | vimentin | 0.0294854 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0287291 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0284387 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0277114 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0275964 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0265811 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0261656 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0258573 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0257845 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0254745 |
| RNF145 | ring finger protein 145 | 0.0247194 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0244465 |
| DST | dystonin | 0.0243462 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0237355 |
| RPL3 | ribosomal protein L3 | 0.0234993 |
| PARVB | parvin, beta | 0.0233018 |
| INSIG2 | insulin induced gene 2 | 0.0229222 |
| SMAD3 | SMAD family member 3 | 0.022405 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0220426 |
| FRMD6 | FERM domain containing 6 | 0.0219818 |
| NDRG1 | N-myc downstream regulated 1 | 0.02196 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0218678 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0216776 |
| MRTFA | myocardin related transcription factor A | 0.0216376 |
| ANXA5 | annexin A5 | 0.0216317 |
| NEK7 | NIMA-related kinase 7 | 0.0215699 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0215013 |
| VGLL4 | vestigial-like family member 4 | 0.0214762 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0210113 |
| SSH1 | slingshot protein phosphatase 1 | 0.0209034 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.0208991 |
| CD109 | CD109 molecule | 0.0208796 |
| WDR45B | WD repeat domain 45B | 0.019993 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0197045 |
| AFDN | afadin, adherens junction formation factor | 0.0197034 |
| NIBAN2 | niban apoptosis regulator 2 | 0.019683 |
| LNPK | lunapark, ER junction formation factor | 0.0196648 |
| PYGB | phosphorylase, glycogen; brain | 0.0193886 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0193252 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.01925 |
| HELZ | helicase with zinc finger | 0.0192035 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0190215 |
| YBX1 | Y box binding protein 1 | 0.0189988 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0189449 |
| FLNB | filamin B, beta | 0.0189401 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0187789 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0186958 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0186672 |
| MCL1 | myeloid cell leukemia 1 | 0.0186621 |
| ZYX | zyxin | 0.0185719 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0185294 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0183802 |
| CCDC47 | coiled-coil domain containing 47 | 0.0182798 |
| CALR | calreticulin | 0.0182115 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0182008 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 0.0180112 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.0179891 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0179579 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0179065 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0176798 |
| NUP58 | nucleoporin 58 | 0.0172329 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.38653 |
| FN1 | fibronectin 1 | -0.228013 |
| EGR1 | early growth response 1 | -0.0970881 |
| FMN1 | formin 1 | -0.0962938 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0699544 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0591295 |
| VCL | vinculin | -0.0583124 |
| TNNC1 | troponin C type 1 (slow) | -0.0564677 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.05449 |
| COL19A1 | collagen, type XIX, alpha 1 | -0.0539614 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0537191 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0495542 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0482988 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0371365 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0361246 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0361131 |
| ATF6 | activating transcription factor 6 | -0.0359838 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0339111 |
| PTCHD4 | patched domain containing 4 | -0.0330987 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0322276 |
| RTN4 | reticulon 4 | -0.03121 |
| ADNP | activity-dependent neuroprotector homeobox | -0.031115 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.03044 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0295872 |
| CALU | calumenin | -0.028775 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0272497 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0268191 |
| MYO1E | myosin IE | -0.0266201 |
| IGF2 | insulin-like growth factor 2 | -0.0265846 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0265263 |
| TRRAP | transformation/transcription domain-associated protein | -0.0262082 |
| PAX3 | paired box 3 | -0.0261861 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0260488 |
| A2M | alpha-2-macroglobulin | -0.0258899 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0255667 |
| CTSD | cathepsin D | -0.0253292 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0251386 |
| FUS | FUS RNA binding protein | -0.0244411 |
| CUX1 | cut-like homeobox 1 | -0.0240379 |
| MMP16 | matrix metallopeptidase 16 (membrane-inserted) | -0.0240377 |
| HLA-B | major histocompatibility complex, class I, B | -0.0235741 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | -0.0235011 |
| HMGA1 | high mobility group AT-hook 1 | -0.022992 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0227847 |
| FRMD4A | FERM domain containing 4A | -0.0225852 |
| TLE4 | transducin-like enhancer of split 4 | -0.0215752 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0214192 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0213742 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0208955 |
| TAGLN2 | transgelin 2 | -0.0204117 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0203048 |
| DCT | dopachrome tautomerase | -0.0202265 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0201461 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0199923 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0199343 |
| BPTF | bromodomain PHD finger transcription factor | -0.0199064 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0197833 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0193821 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.019357 |
| OSMR | oncostatin M receptor | -0.0191985 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0190612 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0188314 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0183491 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0182914 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0182545 |
| SDCBP | syndecan binding protein (syntenin) | -0.018178 |
| ERBIN | erbb2 interacting protein | -0.0178996 |
| LIMA1 | LIM domain and actin binding 1 | -0.0176129 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0174688 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0174471 |
| NLGN1 | neuroligin 1 | -0.0173044 |
| CLIC4 | chloride intracellular channel 4 | -0.0172379 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0172249 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0171982 |
| RHOJ | ras homolog family member J | -0.0171223 |
| ACTG1 | actin gamma 1 | -0.0170952 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | -0.0170536 |
| POTEF | POTE ankyrin domain family, member F | -0.0169848 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0164225 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0163476 |
| CD44 | CD44 molecule (Indian blood group) | -0.016118 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0160658 |
| FHL2 | four and a half LIM domains 2 | -0.0160083 |
| CYTH3 | cytohesin 3 | -0.0159892 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0159281 |
| HDAC9 | histone deacetylase 9 | -0.0158922 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0157673 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0155911 |
| PNLIPRP3 | pancreatic lipase-related protein 3 | -0.0155706 |
| SFTPA2 | surfactant protein A2 | -0.0154931 |
| MTPN | myotrophin | -0.0151189 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0148661 |
| CPQ | carboxypeptidase Q | -0.0147613 |
| RANBP17 | RAN binding protein 17 | -0.0146859 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0146456 |
| GANAB | glucosidase, alpha; neutral AB | -0.0145468 |
| POU2F1 | POU class 2 homeobox 1 | -0.0145089 |
| RPL35A | ribosomal protein L35a | -0.0144818 |
| TRIM24 | tripartite motif containing 24 | -0.0143151 |
| EHBP1 | EH domain binding protein 1 | -0.0142963 |
