| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.0779903 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.075707 |
| MYCN | v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog | 0.0736245 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0444923 |
| PCBP2 | poly(rC) binding protein 2 | 0.0334647 |
| DST | dystonin | 0.0314807 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0301614 |
| DPH6 | diphthamine biosynthesis 6 | 0.0290603 |
| ZNF148 | zinc finger protein 148 | 0.0262406 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0254548 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0253395 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0251821 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0249566 |
| SEPTIN9 | septin 9 | 0.0246152 |
| VEGFA | vascular endothelial growth factor A | 0.0237572 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0224972 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0222335 |
| RPL4 | ribosomal protein L4 | 0.0221727 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0214444 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0213975 |
| RPL3 | ribosomal protein L3 | 0.0211067 |
| YEATS2 | YEATS domain containing 2 | 0.0199185 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0199117 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0197838 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0195912 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.019409 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0191348 |
| RAD51B | RAD51 paralog B | 0.0182405 |
| PFKP | phosphofructokinase, platelet | 0.0180593 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.018018 |
| SSBP3 | single stranded DNA binding protein 3 | 0.0174799 |
| TRIM25 | tripartite motif containing 25 | 0.0173901 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0172374 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0168881 |
| ANO6 | anoctamin 6 | 0.0166709 |
| FAM219A | family with sequence similarity 219, member A | 0.0162785 |
| PTEN | phosphatase and tensin homolog | 0.0162633 |
| ZNF292 | zinc finger protein 292 | 0.0162475 |
| IGSF9B | immunoglobulin superfamily, member 9B | 0.0158002 |
| CDK19 | cyclin-dependent kinase 19 | 0.015746 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.015605 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0155733 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0153806 |
| NGLY1 | N-glycanase 1 | 0.0151505 |
| C1D | C1D nuclear receptor corepressor | 0.0151134 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0150847 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0150428 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0149588 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0147777 |
| AFDN | afadin, adherens junction formation factor | 0.0147631 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | 0.0147615 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.014702 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0145842 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0145773 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.014182 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0140871 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0140022 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0139057 |
| PDGFC | platelet derived growth factor C | 0.0136999 |
| RNF144A | ring finger protein 144A | 0.0136081 |
| TBX2 | T-box 2 | 0.0135975 |
| ZNF160 | zinc finger protein 160 | 0.013513 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0134765 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0134461 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0133116 |
| ANK2 | ankyrin 2, neuronal | 0.0131356 |
| PCBP3 | poly(rC) binding protein 3 | 0.0131119 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0131058 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0129817 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0129329 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0129081 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0128619 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0128059 |
| CCNC | cyclin C | 0.0128047 |
| FNIP1 | folliculin interacting protein 1 | 0.0127096 |
| NBAS | neuroblastoma amplified sequence | 0.0127072 |
| MTSS2 | MTSS I-BAR domain containing 2 | 0.0126406 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0125183 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0123788 |
| DNMBP | dynamin binding protein | 0.0122442 |
| RARA | retinoic acid receptor, alpha | 0.0122246 |
| CABIN1 | calcineurin binding protein 1 | 0.0120571 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0117885 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0117308 |
| PCTP | phosphatidylcholine transfer protein | 0.0116778 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0116349 |
| METTL15 | methyltransferase like 15 | 0.0115751 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0115484 |
| MEIS1 | Meis homeobox 1 | 0.0114954 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0114256 |
| RPS12 | ribosomal protein S12 | 0.0112027 |
| STC2 | stanniocalcin 2 | 0.0111396 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0110861 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.011069 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0110621 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.011057 |
| ZNF395 | zinc finger protein 395 | 0.0110408 |
| LONP1 | lon peptidase 1, mitochondrial | 0.0109711 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.01093 |
| KIAA1671 | KIAA1671 | 0.0108823 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.496096 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.23922 |
| NRG1 | neuregulin 1 | -0.111582 |
| VIM | vimentin | -0.104148 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0988766 |
| RPS6 | ribosomal protein S6 | -0.0802957 |
| LSAMP | limbic system-associated membrane protein | -0.079627 |
| VCL | vinculin | -0.0754703 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0749059 |
| PTMA | prothymosin, alpha | -0.0705694 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.070548 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0692861 |
| SYT1 | synaptotagmin I | -0.0686774 |
| FMN1 | formin 1 | -0.0663105 |
| RPL35A | ribosomal protein L35a | -0.063781 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0624855 |
| MAP1B | microtubule-associated protein 1B | -0.0602933 |
| RPL19 | ribosomal protein L19 | -0.0601907 |
| ACTG1 | actin gamma 1 | -0.0585478 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0555141 |
| IER3 | immediate early response 3 | -0.0552818 |
| RPL23 | ribosomal protein L23 | -0.0546663 |
| RPL34 | ribosomal protein L34 | -0.0534205 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0533096 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0524606 |
| RPL38 | ribosomal protein L38 | -0.0430987 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0419603 |
| COL1A1 | collagen, type I, alpha 1 | -0.0411514 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0403648 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0402559 |
| TMSB10 | thymosin beta 10 | -0.0400266 |
| RPS24 | ribosomal protein S24 | -0.0391467 |
| FTL | ferritin, light polypeptide | -0.0389728 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0387227 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0386183 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0375562 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0373868 |
| CCND1 | cyclin D1 | -0.0368613 |
| LMNA | lamin A/C | -0.0360633 |
| PTK2 | protein tyrosine kinase 2 | -0.035976 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0346686 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0342417 |
| HIP1 | huntingtin interacting protein 1 | -0.0341179 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0340582 |
| H3-3B | H3.3 histone B | -0.0339243 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0338845 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0337961 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0336674 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0330086 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0328234 |
| S100A6 | S100 calcium binding protein A6 | -0.0326238 |
| RPLP1 | ribosomal protein, large, P1 | -0.0325252 |
| TLE4 | transducin-like enhancer of split 4 | -0.0323646 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0323472 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0315843 |
| EGR1 | early growth response 1 | -0.0309486 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -0.0307364 |
| RPLP0 | ribosomal protein, large, P0 | -0.0307299 |
| BPTF | bromodomain PHD finger transcription factor | -0.0296756 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0293979 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0291287 |
| ZNF804A | zinc finger protein 804A | -0.0289439 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0284481 |
| MED13 | mediator complex subunit 13 | -0.0278642 |
| HDLBP | high density lipoprotein binding protein | -0.0277748 |
| TPR | translocated promoter region, nuclear basket protein | -0.0276084 |
| CD36 | CD36 molecule (thrombospondin receptor) | -0.0275736 |
| CEP350 | centrosomal protein 350kDa | -0.0274435 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0273173 |
| RPS19 | ribosomal protein S19 | -0.0271339 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | -0.0268672 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0267938 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0264992 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0264945 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0264438 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0264175 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0263588 |
| CDK12 | cyclin-dependent kinase 12 | -0.0260792 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0260266 |
| CRH | corticotropin releasing hormone | -0.0258511 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.025773 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0257197 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0256751 |
| SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | -0.0254285 |
| FBXO11 | F-box protein 11 | -0.0254262 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0253952 |
| MYO6 | myosin VI | -0.0253713 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0252773 |
| ARF1 | ADP-ribosylation factor 1 | -0.0252457 |
| SPAG9 | sperm associated antigen 9 | -0.0252186 |
| GPATCH8 | G patch domain containing 8 | -0.0251425 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0251137 |
| DSTN | destrin (actin depolymerizing factor) | -0.0250964 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0250051 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0248472 |
| WDR45B | WD repeat domain 45B | -0.0246791 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0246514 |
| RPL26 | ribosomal protein L26 | -0.0244674 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0243944 |
| HAND2 | heart and neural crest derivatives expressed 2 | -0.0243904 |
