| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.111659 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0492664 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0431039 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0430236 |
| RNF149 | ring finger protein 149 | 0.0413137 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0411949 |
| RNF43 | ring finger protein 43 | 0.0406772 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0395475 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0394371 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0341383 |
| CANX | calnexin | 0.0324178 |
| PTEN | phosphatase and tensin homolog | 0.0308992 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0303048 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0299531 |
| TXNIP | thioredoxin interacting protein | 0.0296871 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0280692 |
| OGA | O-GlcNAcase | 0.027688 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0269909 |
| RUNX1 | runt-related transcription factor 1 | 0.0266842 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0265919 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0262613 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0250105 |
| USP3 | ubiquitin specific peptidase 3 | 0.024734 |
| RBM26 | RNA binding motif protein 26 | 0.0241239 |
| MLPH | melanophilin | 0.0237618 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0232356 |
| SBF2 | SET binding factor 2 | 0.0231379 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0231151 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0229791 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0229248 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0228245 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0221326 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0221171 |
| RBM39 | RNA binding motif protein 39 | 0.0220371 |
| HELZ | helicase with zinc finger | 0.0216101 |
| ARHGEF10L | Rho guanine nucleotide exchange factor (GEF) 10-like | 0.0214861 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0214812 |
| TMEM51 | transmembrane protein 51 | 0.0214615 |
| ZNF638 | zinc finger protein 638 | 0.0212259 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0204456 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0203993 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0202952 |
| PRELID2 | PRELI domain containing 2 | 0.0202707 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0200989 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0200325 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0200236 |
| GRAMD2B | GRAM domain containing 2B | 0.0196891 |
| EHF | ets homologous factor | 0.0196334 |
| YEATS2 | YEATS domain containing 2 | 0.0191499 |
| SEC24D | SEC24 family member D | 0.0189487 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0184782 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0184469 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.018256 |
| DIAPH3 | diaphanous-related formin 3 | 0.0182149 |
| NUCB2 | nucleobindin 2 | 0.0180845 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0178715 |
| RASSF6 | Ras association (RalGDS/AF-6) domain family member 6 | 0.0175529 |
| IL20RA | interleukin 20 receptor, alpha | 0.0173213 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0171979 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0171037 |
| ARRDC3 | arrestin domain containing 3 | 0.0170847 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0169416 |
| H1-0 | H1.0 linker histone | 0.0168932 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0167693 |
| TMEM39A | transmembrane protein 39A | 0.016681 |
| HYOU1 | hypoxia up-regulated 1 | 0.0165812 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0164125 |
| AHNAK | AHNAK nucleoprotein | 0.0162131 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | 0.0160536 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0160368 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0159962 |
| TMEM62 | transmembrane protein 62 | 0.0159751 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0159124 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0157826 |
| RNF145 | ring finger protein 145 | 0.0156978 |
| HDLBP | high density lipoprotein binding protein | 0.0156686 |
| LRRC1 | leucine rich repeat containing 1 | 0.0156475 |
| RARS1 | arginyl-tRNA synthetase 1 | 0.0156222 |
| COG6 | component of oligomeric golgi complex 6 | 0.015539 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0155161 |
| SRP54 | signal recognition particle 54kDa | 0.0153512 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0152768 |
| XPO1 | exportin 1 | 0.0152336 |
| IFNGR1 | interferon gamma receptor 1 | 0.0152218 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0151398 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0150314 |
| ZNF652 | zinc finger protein 652 | 0.0147591 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0147167 |
| PREPL | prolyl endopeptidase-like | 0.0147019 |
| AOPEP | aminopeptidase O (putative) | 0.0146716 |
| TUBGCP3 | tubulin, gamma complex associated protein 3 | 0.0144684 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | 0.0144554 |
| SSR1 | signal sequence receptor, alpha | 0.0143943 |
| TMEM245 | transmembrane protein 245 | 0.0143506 |
| EXOC1 | exocyst complex component 1 | 0.0143152 |
| UBAC2 | UBA domain containing 2 | 0.0142988 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0142643 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0142139 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0142087 |
| NEMF | nuclear export mediator factor | 0.014153 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.195628 |
| ANXA2 | annexin A2 | -0.151166 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.149288 |
| INTS6 | integrator complex subunit 6 | -0.145767 |
| EGR1 | early growth response 1 | -0.138325 |
| RNF213 | ring finger protein 213 | -0.128903 |
| LYZ | lysozyme | -0.122176 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.121952 |
| B2M | beta-2-microglobulin | -0.112044 |
| RAB7A | RAB7A, member RAS oncogene family | -0.111653 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.111068 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.106817 |
| SP100 | SP100 nuclear antigen | -0.103223 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.101603 |
| AREG | amphiregulin | -0.099602 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0976591 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0965052 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0935724 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0931776 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0888793 |
| PERP | PERP, TP53 apoptosis effector | -0.0863457 |
| LCN2 | lipocalin 2 | -0.0858285 |
| RIGI | RNA sensor RIG-I | -0.0842141 |
| MX2 | MX dynamin-like GTPase 2 | -0.0797984 |
| ERBIN | erbb2 interacting protein | -0.0789846 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0778361 |
| MX1 | MX dynamin-like GTPase 1 | -0.0776372 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0748732 |
| PLSCR2 | phospholipid scramblase 2 | -0.0739318 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0726093 |
| NPSR1 | neuropeptide S receptor 1 | -0.0725193 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0712304 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0708059 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0680029 |
| ACTG1 | actin gamma 1 | -0.066629 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0661832 |
| PKM | pyruvate kinase, muscle | -0.0646299 |
| TM4SF19 | transmembrane 4 L six family member 19 | -0.063226 |
| VCL | vinculin | -0.0621926 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0621141 |
| PRKCA | protein kinase C, alpha | -0.062031 |
| PTMA | prothymosin, alpha | -0.0615688 |
| TJP1 | tight junction protein 1 | -0.061415 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0613183 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0601279 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0595256 |
| MYO1E | myosin IE | -0.0580794 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0573542 |
| EFNB2 | ephrin-B2 | -0.0561601 |
| XAF1 | XIAP associated factor 1 | -0.0561422 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0551535 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0551077 |
| ASPH | aspartate beta-hydroxylase | -0.0549377 |
| SQSTM1 | sequestosome 1 | -0.0546739 |
| ITGA6 | integrin, alpha 6 | -0.0545141 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0544361 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.053831 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.053553 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0535203 |
| VMP1 | vacuole membrane protein 1 | -0.0531128 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0529881 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0527573 |
| HLA-B | major histocompatibility complex, class I, B | -0.0525108 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.052139 |
| EZR | ezrin | -0.0520571 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0513171 |
| MCL1 | myeloid cell leukemia 1 | -0.0512276 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0507705 |
| FTL | ferritin, light polypeptide | -0.0496788 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0495885 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0494377 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0489819 |
| MAP7 | microtubule-associated protein 7 | -0.0482998 |
| PLSCR1 | phospholipid scramblase 1 | -0.0452285 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0452066 |
| NABP1 | nucleic acid binding protein 1 | -0.0447751 |
| SMAD3 | SMAD family member 3 | -0.0446017 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0445435 |
| UBAP2 | ubiquitin associated protein 2 | -0.0440675 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0438571 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0433079 |
| MCU | mitochondrial calcium uniporter | -0.0420164 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0419755 |
| RPL35A | ribosomal protein L35a | -0.0413762 |
| PMP22 | peripheral myelin protein 22 | -0.0398794 |
| LAMA4 | laminin, alpha 4 | -0.0396283 |
| TMSB10 | thymosin beta 10 | -0.0395772 |
| JUN | jun proto-oncogene | -0.0389374 |
| POTEF | POTE ankyrin domain family, member F | -0.0386347 |
| TMC5 | transmembrane channel-like 5 | -0.0378599 |
| DIAPH1 | diaphanous-related formin 1 | -0.037722 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0371882 |
| KRT19 | keratin 19, type I | -0.0360979 |
| UBC | ubiquitin C | -0.0356064 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.035332 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0352706 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0348988 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0344579 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0335282 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0334248 |
