| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.158078 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0904759 |
| FAM13A | family with sequence similarity 13, member A | 0.0898187 |
| ENO1 | enolase 1, (alpha) | 0.0811878 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0764083 |
| NDRG1 | N-myc downstream regulated 1 | 0.0727899 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0719886 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0609708 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0578963 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0573378 |
| PCBP2 | poly(rC) binding protein 2 | 0.0572873 |
| NAV2 | neuron navigator 2 | 0.0542717 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0541781 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0537317 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0519475 |
| RPL3 | ribosomal protein L3 | 0.0509151 |
| SET | SET nuclear proto-oncogene | 0.0491547 |
| COL5A1 | collagen, type V, alpha 1 | 0.0490567 |
| HELZ | helicase with zinc finger | 0.0464705 |
| ANLN | anillin, actin binding protein | 0.045254 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0446558 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0443548 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0425239 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0420276 |
| CENPF | centromere protein F, 350/400kDa | 0.0410615 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0403351 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0400855 |
| AHNAK | AHNAK nucleoprotein | 0.0400709 |
| TPM3 | tropomyosin 3 | 0.0388878 |
| CALR | calreticulin | 0.0385689 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.03782 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0377907 |
| RPS3 | ribosomal protein S3 | 0.0376942 |
| ZNF160 | zinc finger protein 160 | 0.037642 |
| YBX1 | Y box binding protein 1 | 0.0374447 |
| SRP54 | signal recognition particle 54kDa | 0.0374395 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0373686 |
| OGA | O-GlcNAcase | 0.0372307 |
| MCL1 | myeloid cell leukemia 1 | 0.0371878 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0370395 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0367756 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0365223 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0347671 |
| PRELID2 | PRELI domain containing 2 | 0.0339324 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.03386 |
| TXNIP | thioredoxin interacting protein | 0.0331972 |
| MSN | moesin | 0.0331485 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0331275 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0330832 |
| VEGFA | vascular endothelial growth factor A | 0.0329567 |
| STC1 | stanniocalcin 1 | 0.0324987 |
| SDC4 | syndecan 4 | 0.032423 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0319885 |
| PTMA | prothymosin, alpha | 0.0318262 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0314013 |
| CORO1C | coronin, actin binding protein, 1C | 0.0313033 |
| POTEF | POTE ankyrin domain family, member F | 0.030895 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.030775 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) | 0.0305782 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0300211 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0300119 |
| FNIP1 | folliculin interacting protein 1 | 0.0296292 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0291438 |
| FAM219A | family with sequence similarity 219, member A | 0.0284856 |
| B2M | beta-2-microglobulin | 0.0283697 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0280522 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0280208 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.027844 |
| RPL4 | ribosomal protein L4 | 0.0278172 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0276936 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0272897 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0269717 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0269586 |
| INSIG2 | insulin induced gene 2 | 0.0267819 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.026673 |
| YEATS2 | YEATS domain containing 2 | 0.0264474 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0262679 |
| FLNB | filamin B, beta | 0.0262135 |
| ZNF395 | zinc finger protein 395 | 0.0261871 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0261032 |
| ZNF841 | zinc finger protein 841 | 0.0260623 |
| RPL37A | ribosomal protein L37a | 0.0259354 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.025859 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0258007 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0256894 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0256355 |
| MYOF | myoferlin | 0.0255021 |
| APP | amyloid beta (A4) precursor protein | 0.0254172 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0252163 |
| PRRC2C | proline-rich coiled-coil 2C | 0.024853 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0247342 |
| VIM | vimentin | 0.024605 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0245424 |
| AXL | AXL receptor tyrosine kinase | 0.0242849 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0239227 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0239151 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0238165 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0236927 |
| DTNA | dystrobrevin, alpha | 0.0236075 |
| NGLY1 | N-glycanase 1 | 0.023592 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.31492 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.179323 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.169005 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.12683 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.117801 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0958665 |
| FN1 | fibronectin 1 | -0.0929063 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0898195 |
| TNNC1 | troponin C type 1 (slow) | -0.0774126 |
| OSMR | oncostatin M receptor | -0.0731957 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0699182 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0658837 |
| RTN4 | reticulon 4 | -0.0646803 |
| MAP1B | microtubule-associated protein 1B | -0.0591013 |
| CD44 | CD44 molecule (Indian blood group) | -0.0542487 |
| KYNU | kynureninase | -0.0517268 |
| INHBA | inhibin, beta A | -0.0495067 |
| TMSB10 | thymosin beta 10 | -0.0492933 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0460627 |
| SCFD2 | sec1 family domain containing 2 | -0.0454271 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0444258 |
| LOX | lysyl oxidase | -0.0441169 |
| HLA-B | major histocompatibility complex, class I, B | -0.0435582 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0430042 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0422286 |
| TPM4 | tropomyosin 4 | -0.0403921 |
| MAP4 | microtubule-associated protein 4 | -0.0401811 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0395279 |
| VCL | vinculin | -0.0388366 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0387398 |
| TENM3 | teneurin transmembrane protein 3 | -0.0384991 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0370652 |
| TUBB | tubulin, beta class I | -0.037006 |
| AK1 | adenylate kinase 1 | -0.0364447 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0362314 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0354884 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0352244 |
| SBF2 | SET binding factor 2 | -0.0351474 |
| RPS6 | ribosomal protein S6 | -0.0349887 |
| GLIS3 | GLIS family zinc finger 3 | -0.0343987 |
| GPHN | gephyrin | -0.0343682 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0343354 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0342493 |
| HDLBP | high density lipoprotein binding protein | -0.0341961 |
| ARF1 | ADP-ribosylation factor 1 | -0.0340658 |
| IL6ST | interleukin 6 signal transducer | -0.0339473 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.032904 |
| TXNRD1 | thioredoxin reductase 1 | -0.0326694 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0323639 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0317876 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0317022 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0315689 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0314579 |
| CCND1 | cyclin D1 | -0.0312816 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0304562 |
| FUS | FUS RNA binding protein | -0.0299977 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.029895 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0297135 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0296354 |
| PTCHD4 | patched domain containing 4 | -0.0293482 |
| TNS3 | tensin 3 | -0.0292753 |
| LRRC49 | leucine rich repeat containing 49 | -0.0290533 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0284782 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0284035 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0283912 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0283266 |
| RPS24 | ribosomal protein S24 | -0.0281572 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0280632 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0278378 |
| NF1 | neurofibromin 1 | -0.0277629 |
| TCF12 | transcription factor 12 | -0.0275112 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0274112 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0273958 |
| CADM1 | cell adhesion molecule 1 | -0.027208 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0269856 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0266531 |
| STK17A | serine/threonine kinase 17a | -0.0265983 |
| CALU | calumenin | -0.0259509 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0259378 |
| RPLP0 | ribosomal protein, large, P0 | -0.0258896 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0258151 |
| PHF14 | PHD finger protein 14 | -0.0257978 |
| RRBP1 | ribosome binding protein 1 | -0.0256656 |
| RPL34 | ribosomal protein L34 | -0.025303 |
| PTK2 | protein tyrosine kinase 2 | -0.0250977 |
| PALLD | palladin, cytoskeletal associated protein | -0.0248403 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0248063 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0247971 |
| COMMD10 | COMM domain containing 10 | -0.0247762 |
| RPL35A | ribosomal protein L35a | -0.0247067 |
| SQSTM1 | sequestosome 1 | -0.024622 |
| CDK6 | cyclin-dependent kinase 6 | -0.0243416 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0242296 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0240833 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0239827 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0239708 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0236091 |
| MYO9A | myosin IXA | -0.0235751 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0234445 |
| RNF216 | ring finger protein 216 | -0.0233968 |
