| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.148861 |
| AHNAK | AHNAK nucleoprotein | 0.108463 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0935704 |
| PRELID2 | PRELI domain containing 2 | 0.0730431 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.066791 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0628788 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0582371 |
| ENO1 | enolase 1, (alpha) | 0.0551814 |
| RPL3 | ribosomal protein L3 | 0.052064 |
| PCBP2 | poly(rC) binding protein 2 | 0.0520361 |
| YEATS2 | YEATS domain containing 2 | 0.0516916 |
| MCL1 | myeloid cell leukemia 1 | 0.0496636 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0443199 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0434144 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0422365 |
| ZNF292 | zinc finger protein 292 | 0.0401882 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0396439 |
| RPL4 | ribosomal protein L4 | 0.0395288 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0390249 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0379302 |
| WDR26 | WD repeat domain 26 | 0.035762 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0348886 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0348033 |
| CCNG2 | cyclin G2 | 0.0346424 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.034499 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0343602 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0337266 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0331334 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0325917 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0319334 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0318679 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0314788 |
| RPL37A | ribosomal protein L37a | 0.0311295 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0311036 |
| NEBL | nebulette | 0.0308219 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0296531 |
| HELZ | helicase with zinc finger | 0.0294427 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0289612 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0288115 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0281132 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0276155 |
| RPS2 | ribosomal protein S2 | 0.0275774 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0275641 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0272249 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0271053 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0270111 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0268417 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0266472 |
| RUNX1 | runt-related transcription factor 1 | 0.0266057 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0264976 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0259774 |
| MNMIP1 | manchette microtubule inner protein 1 | 0.025941 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0257676 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0256356 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0255012 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0254281 |
| PFKP | phosphofructokinase, platelet | 0.0244966 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.024289 |
| NBAS | neuroblastoma amplified sequence | 0.0242636 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0241091 |
| HYOU1 | hypoxia up-regulated 1 | 0.0239493 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0239435 |
| RPS3 | ribosomal protein S3 | 0.0239127 |
| RAD51B | RAD51 paralog B | 0.0238858 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0238672 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.023846 |
| PTEN | phosphatase and tensin homolog | 0.0236389 |
| SMYD3 | SET and MYND domain containing 3 | 0.0235514 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0234315 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0233642 |
| BRD4 | bromodomain containing 4 | 0.0233083 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0233011 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0232552 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0232045 |
| YAP1 | Yes-associated protein 1 | 0.022968 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.02293 |
| TPM3 | tropomyosin 3 | 0.0229286 |
| ZNF638 | zinc finger protein 638 | 0.0228957 |
| RPS12 | ribosomal protein S12 | 0.0227405 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0224174 |
| WWC2 | WW and C2 domain containing 2 | 0.0223186 |
| EPN2 | epsin 2 | 0.0221153 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0219428 |
| USP34 | ubiquitin specific peptidase 34 | 0.0218248 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0217657 |
| WWOX | WW domain containing oxidoreductase | 0.0217042 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0216519 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.021535 |
| CDK19 | cyclin-dependent kinase 19 | 0.0213006 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0211336 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.021072 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0209915 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0209388 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0208331 |
| ATXN1 | ataxin 1 | 0.0207075 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0204924 |
| PLEC | plectin | 0.020492 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0204781 |
| NCKAP1 | NCK-associated protein 1 | 0.0203459 |
| POTEF | POTE ankyrin domain family, member F | 0.0203335 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.363688 |
| PTMA | prothymosin, alpha | -0.138692 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.107053 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.106145 |
| TMSB10 | thymosin beta 10 | -0.0947565 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.078187 |
| FTL | ferritin, light polypeptide | -0.0773031 |
| NDRG1 | N-myc downstream regulated 1 | -0.0689708 |
| RPS6 | ribosomal protein S6 | -0.0637478 |
| RPL35A | ribosomal protein L35a | -0.0593754 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0528206 |
| RPS24 | ribosomal protein S24 | -0.0469824 |
| RPL8 | ribosomal protein L8 | -0.0456153 |
| S100A10 | S100 calcium binding protein A10 | -0.0452042 |
| ARF4 | ADP-ribosylation factor 4 | -0.0447172 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0441278 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0427146 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0424671 |
| MKI67 | marker of proliferation Ki-67 | -0.0412541 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0412367 |
| RPLP0 | ribosomal protein, large, P0 | -0.0382749 |
| FAT1 | FAT atypical cadherin 1 | -0.0377545 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0377441 |
| JMJD1C | jumonji domain containing 1C | -0.0376172 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0357176 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0356783 |
| SCFD2 | sec1 family domain containing 2 | -0.0352797 |
| TUBB | tubulin, beta class I | -0.0343605 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0342502 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0341505 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0338094 |
| RPL34 | ribosomal protein L34 | -0.0335427 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0329832 |
| HMGA1 | high mobility group AT-hook 1 | -0.0329166 |
| CCNI | cyclin I | -0.0314474 |
| FUS | FUS RNA binding protein | -0.0314155 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0313062 |
| FRMD5 | FERM domain containing 5 | -0.0312086 |
| DIAPH3 | diaphanous-related formin 3 | -0.0309936 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0306813 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0303861 |
| TUBA1B | tubulin, alpha 1b | -0.0303834 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0295031 |
| RPL12 | ribosomal protein L12 | -0.0294736 |
| KRT19 | keratin 19, type I | -0.0294631 |
| S100A9 | S100 calcium binding protein A9 | -0.0293523 |
| HMGB1 | high mobility group box 1 | -0.029289 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0292397 |
| RPS25 | ribosomal protein S25 | -0.0286257 |
| CCND1 | cyclin D1 | -0.0286128 |
| TMEM123 | transmembrane protein 123 | -0.028539 |
| EGR1 | early growth response 1 | -0.0285247 |
| MT2A | metallothionein 2A | -0.0284788 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.028308 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0282281 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0280181 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0273832 |
| WASF2 | WAS protein family, member 2 | -0.0273268 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0266772 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0264838 |
| DSG2 | desmoglein 2 | -0.0262968 |
| MORF4L2 | mortality factor 4 like 2 | -0.026114 |
| RPS15 | ribosomal protein S15 | -0.0259855 |
| RPS13 | ribosomal protein S13 | -0.0258417 |
| WDR45B | WD repeat domain 45B | -0.0258291 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0257971 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0257874 |
| H1-0 | H1.0 linker histone | -0.0251599 |
| SERINC5 | serine incorporator 5 | -0.0250644 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0250613 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0250471 |
| EHBP1 | EH domain binding protein 1 | -0.0249324 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0247522 |
| TAOK1 | TAO kinase 1 | -0.0246132 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0245391 |
| RPL32 | ribosomal protein L32 | -0.0245182 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0244031 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.024356 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0242246 |
| TMEM263 | transmembrane protein 263 | -0.0241286 |
| NOP58 | NOP58 ribonucleoprotein | -0.0240064 |
| SRP72 | signal recognition particle 72kDa | -0.0234037 |
| CDCP1 | CUB domain containing protein 1 | -0.0230317 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0227122 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0227061 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0223315 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0222715 |
| RPS11 | ribosomal protein S11 | -0.0222507 |
| TCF12 | transcription factor 12 | -0.0221865 |
| RPL19 | ribosomal protein L19 | -0.0219607 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0218223 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0216941 |
| RPS21 | ribosomal protein S21 | -0.0216915 |
| NBEAL1 | neurobeachin-like 1 | -0.0213238 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0212656 |
| CENPF | centromere protein F, 350/400kDa | -0.0212552 |
| SEPTIN7 | septin 7 | -0.0210571 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0209315 |
| GLG1 | golgi glycoprotein 1 | -0.0207684 |
| S100A6 | S100 calcium binding protein A6 | -0.0207165 |
