Ivabradine (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0655342
PSD3 pleckstrin and Sec7 domain containing 3 0.0485414
MYH9 myosin, heavy chain 9, non-muscle 0.0431458
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0428958
ASPH aspartate beta-hydroxylase 0.041993
APP amyloid beta (A4) precursor protein 0.0394562
PRELID2 PRELI domain containing 2 0.0390353
FNDC3B fibronectin type III domain containing 3B 0.0358304
PAX8 paired box 8 0.0337132
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0336444
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0327525
OSBPL10 oxysterol binding protein-like 10 0.0314383
ANKRD36 ankyrin repeat domain 36 0.0305912
SVIL supervillin 0.027644
RPL3 ribosomal protein L3 0.0274894
VCAN versican 0.0274364
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0273798
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0271425
ERRFI1 ERBB receptor feedback inhibitor 1 0.0261616
AFDN afadin, adherens junction formation factor 0.0254886
USP9X ubiquitin specific peptidase 9, X-linked 0.0253572
RAD51B RAD51 paralog B 0.0242755
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0241073
MACF1 microtubule-actin crosslinking factor 1 0.024088
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0231466
SMYD3 SET and MYND domain containing 3 0.022997
ANXA3 annexin A3 0.022787
POTEF POTE ankyrin domain family, member F 0.0226016
ITGB8 integrin, beta 8 0.0225324
LIMCH1 LIM and calponin homology domains 1 0.0223887
LAMC2 laminin, gamma 2 0.0222764
TPM3 tropomyosin 3 0.022126
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0212141
ECT2 epithelial cell transforming 2 0.021194
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208178
SBF2 SET binding factor 2 0.020739
HMGA2 high mobility group AT-hook 2 0.0199171
ZNF644 zinc finger protein 644 0.0198249
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.019748
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.019255
LPP LIM domain containing preferred translocation partner in lipoma 0.019233
SYNE2 spectrin repeat containing, nuclear envelope 2 0.019145
DIAPH1 diaphanous-related formin 1 0.0187865
PTBP2 polypyrimidine tract binding protein 2 0.0185707
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0184056
ZNF148 zinc finger protein 148 0.0183932
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0182275
ANKRD11 ankyrin repeat domain 11 0.0181983
PICALM phosphatidylinositol binding clathrin assembly protein 0.0180224
HELZ helicase with zinc finger 0.0179493
EIF4B eukaryotic translation initiation factor 4B 0.017329
RBM26 RNA binding motif protein 26 0.0171993
FNBP1L formin binding protein 1-like 0.0171256
PDGFC platelet derived growth factor C 0.0167685
KDM6A lysine (K)-specific demethylase 6A 0.016765
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0167201
CTBP2 C-terminal binding protein 2 0.0167178
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 0.0164103
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0162504
ZC3H11A zinc finger CCCH-type containing 11A 0.0162311
GPR39 G protein-coupled receptor 39 0.0161301
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0160968
MYEOV myeloma overexpressed 0.0155457
MACC1 metastasis associated in colon cancer 1 0.0152887
ANO6 anoctamin 6 0.0151638
BCAR3 breast cancer anti-estrogen resistance 3 0.0150683
TBC1D5 TBC1 domain family, member 5 0.0150047
EGFR epidermal growth factor receptor 0.0149651
SLTM SAFB-like, transcription modulator 0.0148336
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0148032
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0147853
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.014617
YAP1 Yes-associated protein 1 0.0145102
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0144803
TBC1D22A TBC1 domain family, member 22A 0.0144762
USP24 ubiquitin specific peptidase 24 0.0143897
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0143857
PTPRK protein tyrosine phosphatase, receptor type, K 0.0143336
FNIP1 folliculin interacting protein 1 0.0142788
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0142554
UBASH3B ubiquitin associated and SH3 domain containing B 0.0142298
SET SET nuclear proto-oncogene 0.0140956
TBCD tubulin folding cofactor D 0.014067
FMNL2 formin-like 2 0.0139762
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0139159
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0138559
PCBP2 poly(rC) binding protein 2 0.0136109
EXOC4 exocyst complex component 4 0.0135867
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0135645
TNIP1 TNFAIP3 interacting protein 1 0.0133912
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0133887
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0133734
ITGA6 integrin, alpha 6 0.0133666
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.013295
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0132935
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0132744
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0129602
ECPAS Ecm29 proteasome adaptor and scaffold 0.0129011
VMP1 vacuole membrane protein 1 0.0128663
CCDC93 coiled-coil domain containing 93 0.0125241

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.3424
MT2A metallothionein 2A -0.191798
FTL ferritin, light polypeptide -0.154604
TPT1 tumor protein, translationally-controlled 1 -0.154422
RPL35A ribosomal protein L35a -0.143016
TMSB10 thymosin beta 10 -0.142091
RPS19 ribosomal protein S19 -0.112202
RPS6 ribosomal protein S6 -0.106458
RPLP1 ribosomal protein, large, P1 -0.0950896
RPL31 ribosomal protein L31 -0.0913123
RPS8 ribosomal protein S8 -0.0909512
RPL19 ribosomal protein L19 -0.0908244
RPL32 ribosomal protein L32 -0.088621
RPL12 ribosomal protein L12 -0.0863248
B2M beta-2-microglobulin -0.0858563
ACTG1 actin gamma 1 -0.0850763
RPLP2 ribosomal protein, large, P2 -0.0744754
RPL23 ribosomal protein L23 -0.0713379
RPL34 ribosomal protein L34 -0.0704974
RPL28 ribosomal protein L28 -0.0661698
CCND1 cyclin D1 -0.0649698
EIF1 eukaryotic translation initiation factor 1 -0.0641058
RPL35 ribosomal protein L35 -0.0634696
RPLP0 ribosomal protein, large, P0 -0.0623729
S100A10 S100 calcium binding protein A10 -0.0607223
RPL11 ribosomal protein L11 -0.05977
RPL9 ribosomal protein L9 -0.058237
RPS11 ribosomal protein S11 -0.0577253
RPS29 ribosomal protein S29 -0.055293
RPS16 ribosomal protein S16 -0.0538203
RPS14 ribosomal protein S14 -0.0535171
RPL36 ribosomal protein L36 -0.0519447
RPS27A ribosomal protein S27a -0.0512701
RPS13 ribosomal protein S13 -0.0512567
PKM pyruvate kinase, muscle -0.0505003
RPS23 ribosomal protein S23 -0.0501951
RPL26 ribosomal protein L26 -0.0495881
PTMA prothymosin, alpha -0.0486521
RPS25 ribosomal protein S25 -0.0479477
S100A6 S100 calcium binding protein A6 -0.0471053
RPS15 ribosomal protein S15 -0.0465653
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0464446
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0460216
RPS24 ribosomal protein S24 -0.0456495
EGR1 early growth response 1 -0.0450459
RPL37A ribosomal protein L37a -0.0446624
RPL8 ribosomal protein L8 -0.0445334
RPL7A ribosomal protein L7a -0.0442677
MT1X metallothionein 1X -0.0438639
RPS5 ribosomal protein S5 -0.0434058
RPL38 ribosomal protein L38 -0.0430979
TUBB4B tubulin, beta 4B class IVb -0.0419047
TPI1 triosephosphate isomerase 1 -0.0415667
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0408395
RPS10 ribosomal protein S10 -0.0400423
RPL5 ribosomal protein L5 -0.0399034
GNAS GNAS complex locus -0.0388343
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0386834
RPS27 ribosomal protein S27 -0.0381557
RACK1 receptor for activated C kinase 1 -0.0374297
RPS4X ribosomal protein S4, X-linked -0.0372561
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0368932
RPS21 ribosomal protein S21 -0.0368434
RPL30 ribosomal protein L30 -0.0365079
RPL37 ribosomal protein L37 -0.0363677
RPS12 ribosomal protein S12 -0.0361735
EEF1G eukaryotic translation elongation factor 1 gamma -0.0361649
RPL18 ribosomal protein L18 -0.0357078
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0355799
WSB1 WD repeat and SOCS box containing 1 -0.0350106
LOC112694756 uncharaterized LOC112694756 -0.034789
VDAC1 voltage-dependent anion channel 1 -0.0339473
RPL15 ribosomal protein L15 -0.0336445
RPS3 ribosomal protein S3 -0.0329001
GSTP1 glutathione S-transferase pi 1 -0.0322017
HMGB1 high mobility group box 1 -0.0321946
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0318191
CCNI cyclin I -0.0315852
RPL27A ribosomal protein L27a -0.0311409
RPS17 ribosomal protein S17 -0.0306567
TUBB tubulin, beta class I -0.0302129
SEPTIN7 septin 7 -0.0300303
H3-3B H3.3 histone B -0.030024
RPL13A ribosomal protein L13a -0.0296735
DEK DEK proto-oncogene -0.0295768
RPL36A ribosomal protein L36a -0.0289364
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0289127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0283552
CDCP1 CUB domain containing protein 1 -0.028267
MYL12B myosin, light chain 12B, regulatory -0.028261
H1-0 H1.0 linker histone -0.0279672
WDR45B WD repeat domain 45B -0.0277996
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0277318
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0276695
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.027467
LDHA lactate dehydrogenase A -0.0273926
S100A9 S100 calcium binding protein A9 -0.0273645
PFN1 profilin 1 -0.0271913
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0271231
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0271049