| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.11782 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.114949 |
| FAM13A | family with sequence similarity 13, member A | 0.0843213 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0591984 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0584599 |
| FLNB | filamin B, beta | 0.0555679 |
| COL5A1 | collagen, type V, alpha 1 | 0.0524517 |
| MCL1 | myeloid cell leukemia 1 | 0.0500111 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0484026 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0436485 |
| NDRG1 | N-myc downstream regulated 1 | 0.0423079 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0377719 |
| PRELID2 | PRELI domain containing 2 | 0.0373821 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.037069 |
| ENO1 | enolase 1, (alpha) | 0.0344217 |
| NGLY1 | N-glycanase 1 | 0.0338938 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0310962 |
| RPL3 | ribosomal protein L3 | 0.0302717 |
| PCBP3 | poly(rC) binding protein 3 | 0.0302095 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0294514 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0294352 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0291787 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0291171 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0287814 |
| TNS1 | tensin 1 | 0.0286182 |
| RUNX1 | runt-related transcription factor 1 | 0.0284869 |
| SEPTIN9 | septin 9 | 0.0281523 |
| VEGFA | vascular endothelial growth factor A | 0.028117 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0266965 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0264512 |
| PCBP2 | poly(rC) binding protein 2 | 0.0262466 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0259112 |
| CD109 | CD109 molecule | 0.025772 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0256722 |
| CAPRIN2 | caprin family member 2 | 0.0250359 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0245474 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.024204 |
| PDE10A | phosphodiesterase 10A | 0.0240594 |
| CEP192 | centrosomal protein 192kDa | 0.0235379 |
| LOX | lysyl oxidase | 0.0231347 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0227662 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0226175 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0223868 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0218858 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0215073 |
| YEATS2 | YEATS domain containing 2 | 0.0212601 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0212522 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0212252 |
| RASA3 | RAS p21 protein activator 3 | 0.0211007 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0209609 |
| MSN | moesin | 0.0207458 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0205506 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.02053 |
| MLPH | melanophilin | 0.0204372 |
| INSIG2 | insulin induced gene 2 | 0.0204208 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0202202 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0198268 |
| DTNA | dystrobrevin, alpha | 0.0195088 |
| CDK19 | cyclin-dependent kinase 19 | 0.0194791 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0192966 |
| SET | SET nuclear proto-oncogene | 0.0192904 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0192345 |
| RNF149 | ring finger protein 149 | 0.0190448 |
| AXL | AXL receptor tyrosine kinase | 0.0190094 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0183245 |
| ZNF148 | zinc finger protein 148 | 0.0182253 |
| NAV2 | neuron navigator 2 | 0.0181558 |
| EFNA5 | ephrin-A5 | 0.0181033 |
| SPAG9 | sperm associated antigen 9 | 0.0179908 |
| ACTN1 | actinin, alpha 1 | 0.017788 |
| IRS2 | insulin receptor substrate 2 | 0.0177736 |
| DUSP6 | dual specificity phosphatase 6 | 0.0175722 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0174421 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0171664 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0169705 |
| L1CAM | L1 cell adhesion molecule | 0.0169168 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0167756 |
| FAM219A | family with sequence similarity 219, member A | 0.0166745 |
| SPAG5 | sperm associated antigen 5 | 0.0165933 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0165411 |
| SMAD3 | SMAD family member 3 | 0.0164928 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0162959 |
| WDR26 | WD repeat domain 26 | 0.0161821 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0161658 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0160444 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0160375 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0159648 |
| APP | amyloid beta (A4) precursor protein | 0.0159329 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.015894 |
| HPCAL1 | hippocalcin-like 1 | 0.0156586 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0156538 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0155871 |
| SRP54 | signal recognition particle 54kDa | 0.0155261 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0150948 |
| CCNL1 | cyclin L1 | 0.01503 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0150288 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0144694 |
| TPM3 | tropomyosin 3 | 0.0144128 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0144046 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0143419 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.482745 |
| VIM | vimentin | -0.238101 |
| TMSB10 | thymosin beta 10 | -0.131937 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0952824 |
| CD44 | CD44 molecule (Indian blood group) | -0.0936853 |
| IGF2 | insulin-like growth factor 2 | -0.0785169 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0779412 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.07701 |
| RPS6 | ribosomal protein S6 | -0.0749825 |
| FN1 | fibronectin 1 | -0.0691141 |
| IER3 | immediate early response 3 | -0.0681306 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0610834 |
| CCND1 | cyclin D1 | -0.0549132 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0541652 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0528262 |
| RPL35A | ribosomal protein L35a | -0.0481047 |
| FTL | ferritin, light polypeptide | -0.0479454 |
| RPL12 | ribosomal protein L12 | -0.0461692 |
| RPS24 | ribosomal protein S24 | -0.0452237 |
| CDH13 | cadherin 13 | -0.0447154 |
| EGR1 | early growth response 1 | -0.0426901 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0421799 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0418518 |
| MT2A | metallothionein 2A | -0.0415567 |
| S100A10 | S100 calcium binding protein A10 | -0.0412011 |
| RPLP1 | ribosomal protein, large, P1 | -0.0406155 |
| RPL34 | ribosomal protein L34 | -0.0393603 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0382831 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0380646 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0371383 |
| HMGA1 | high mobility group AT-hook 1 | -0.0367269 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0352155 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0343075 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0340781 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0335298 |
| RRBP1 | ribosome binding protein 1 | -0.0330283 |
| VDAC1 | voltage-dependent anion channel 1 | -0.032923 |
| RPLP0 | ribosomal protein, large, P0 | -0.0327736 |
| GNAS | GNAS complex locus | -0.0323177 |
| ANXA2 | annexin A2 | -0.0322884 |
| TUBB | tubulin, beta class I | -0.0316208 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0316002 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0307773 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0300198 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0297472 |
| RPS8 | ribosomal protein S8 | -0.0291925 |
| MAP1B | microtubule-associated protein 1B | -0.0290351 |
| HMGA2 | high mobility group AT-hook 2 | -0.0286319 |
| RPL8 | ribosomal protein L8 | -0.0282909 |
| MORF4L2 | mortality factor 4 like 2 | -0.0281533 |
| EMP1 | epithelial membrane protein 1 | -0.0281442 |
| RPS16 | ribosomal protein S16 | -0.0279286 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0278193 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0273356 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.02717 |
| TPI1 | triosephosphate isomerase 1 | -0.026805 |
| RPL32 | ribosomal protein L32 | -0.0264803 |
| HDLBP | high density lipoprotein binding protein | -0.0264098 |
| STC1 | stanniocalcin 1 | -0.0263345 |
| FBXO11 | F-box protein 11 | -0.026029 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0257752 |
| CLMP | CXADR-like membrane protein | -0.0248904 |
| RAB7A | RAB7A, member RAS oncogene family | -0.024806 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0242442 |
| MAP4 | microtubule-associated protein 4 | -0.024226 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0241997 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0241236 |
| GLIS3 | GLIS family zinc finger 3 | -0.0239949 |
| ARF1 | ADP-ribosylation factor 1 | -0.0237351 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0234848 |
| RAI14 | retinoic acid induced 14 | -0.023341 |
| LMNA | lamin A/C | -0.0227706 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.022162 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0220706 |
| RPS19 | ribosomal protein S19 | -0.0218511 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.021842 |
| TXNRD1 | thioredoxin reductase 1 | -0.0215404 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0215394 |
| FUS | FUS RNA binding protein | -0.0215136 |
| RPLP2 | ribosomal protein, large, P2 | -0.0214987 |
| NF1 | neurofibromin 1 | -0.0214146 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.021216 |
| INHBA | inhibin, beta A | -0.0209498 |
| RPL27A | ribosomal protein L27a | -0.0205726 |
| QKI | QKI, KH domain containing, RNA binding | -0.0205561 |
| HMGB1 | high mobility group box 1 | -0.0204397 |
| CANX | calnexin | -0.020432 |
| TUBB6 | tubulin, beta 6 class V | -0.0203943 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0203181 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0203159 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0202292 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0202197 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0201431 |
| CDCP1 | CUB domain containing protein 1 | -0.0200438 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0198316 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0196801 |
| RPS21 | ribosomal protein S21 | -0.0196419 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0196172 |
| RPL28 | ribosomal protein L28 | -0.0194788 |
| CLIC4 | chloride intracellular channel 4 | -0.0194164 |
