| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.12363 |
| ENO1 | enolase 1, (alpha) | 0.116808 |
| ATP13A3 | ATPase type 13A3 | 0.0996049 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0973963 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0877373 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.08528 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0841654 |
| AHNAK | AHNAK nucleoprotein | 0.0832276 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0746537 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0699212 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0655105 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0631967 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0618033 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0602796 |
| SMAD3 | SMAD family member 3 | 0.0575823 |
| LOXL2 | lysyl oxidase-like 2 | 0.0538041 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0534333 |
| PTMA | prothymosin, alpha | 0.0531096 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.052824 |
| APP | amyloid beta (A4) precursor protein | 0.0489413 |
| COL3A1 | collagen, type III, alpha 1 | 0.0488802 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0454546 |
| TPM4 | tropomyosin 4 | 0.0453775 |
| CANX | calnexin | 0.044887 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0423698 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0419985 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0396561 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0395425 |
| ANXA2 | annexin A2 | 0.0387971 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0374199 |
| SPAG9 | sperm associated antigen 9 | 0.0371118 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0366918 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0358313 |
| STC1 | stanniocalcin 1 | 0.0354381 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0351545 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0348341 |
| CALR | calreticulin | 0.0342277 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0338197 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0325037 |
| RPL3 | ribosomal protein L3 | 0.0316679 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0307398 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0300861 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0294817 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0292764 |
| ZNF292 | zinc finger protein 292 | 0.0290021 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0287665 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0281806 |
| TMSB4X | thymosin beta 4, X-linked | 0.0280362 |
| SQLE | squalene epoxidase | 0.0277992 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0274181 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0270356 |
| RPS3 | ribosomal protein S3 | 0.0270028 |
| ASPH | aspartate beta-hydroxylase | 0.0268662 |
| COL1A1 | collagen, type I, alpha 1 | 0.0263767 |
| YBX1 | Y box binding protein 1 | 0.0260286 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0257669 |
| PRELID2 | PRELI domain containing 2 | 0.025528 |
| OGA | O-GlcNAcase | 0.0252839 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.0250456 |
| CENPF | centromere protein F, 350/400kDa | 0.0244699 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0243491 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0241225 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0240212 |
| RASA2 | RAS p21 protein activator 2 | 0.023849 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0229076 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0228407 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0226832 |
| PTK2 | protein tyrosine kinase 2 | 0.0226656 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0222958 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0219385 |
| SDC4 | syndecan 4 | 0.0219186 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0219111 |
| RPS12 | ribosomal protein S12 | 0.0218052 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0215758 |
| LDHA | lactate dehydrogenase A | 0.0215656 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0215096 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0214873 |
| VIM | vimentin | 0.0213062 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0213011 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0211105 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0210941 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0209892 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0207876 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0206438 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0206098 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0205573 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0204451 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0203569 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0203465 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.020293 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0199654 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0199016 |
| PLEC | plectin | 0.019821 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0191914 |
| TPR | translocated promoter region, nuclear basket protein | 0.0191276 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0190717 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0188269 |
| FAM20C | family with sequence similarity 20, member C | 0.0187012 |
| AFAP1 | actin filament associated protein 1 | 0.0181722 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0180527 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.278432 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.201064 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.142243 |
| NDRG1 | N-myc downstream regulated 1 | -0.115294 |
| FN1 | fibronectin 1 | -0.0771437 |
| MT2A | metallothionein 2A | -0.0742506 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.069438 |
| CDH13 | cadherin 13 | -0.0680748 |
| CADM1 | cell adhesion molecule 1 | -0.0565424 |
| COL6A1 | collagen, type VI, alpha 1 | -0.048509 |
| RPL35A | ribosomal protein L35a | -0.0459778 |
| LOX | lysyl oxidase | -0.0448457 |
| EGFR | epidermal growth factor receptor | -0.0398471 |
| EGR1 | early growth response 1 | -0.0387235 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0376634 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0369556 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0364719 |
| GOLGB1 | golgin B1 | -0.0351001 |
| PFN1 | profilin 1 | -0.0302925 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0301178 |
| CALD1 | caldesmon 1 | -0.028985 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0286881 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0279122 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0277008 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0272922 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.026514 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0264557 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0263024 |
| MYADM | myeloid-associated differentiation marker | -0.0262507 |
| FBN1 | fibrillin 1 | -0.0252698 |
| RPL28 | ribosomal protein L28 | -0.0251042 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0246317 |
| RPS6 | ribosomal protein S6 | -0.0246199 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0240946 |
| WASF2 | WAS protein family, member 2 | -0.0237017 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0234374 |
| HMGA1 | high mobility group AT-hook 1 | -0.0232778 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0220448 |
| RPS15 | ribosomal protein S15 | -0.021945 |
| FTL | ferritin, light polypeptide | -0.0216386 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0214635 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0211124 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0209563 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0209522 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0206783 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0206607 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0206519 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0203143 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0202556 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0201945 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0201486 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0200573 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0198923 |
| RPL8 | ribosomal protein L8 | -0.0198723 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0194417 |
| HM13 | histocompatibility (minor) 13 | -0.0193934 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0192117 |
| TMSB10 | thymosin beta 10 | -0.0190973 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0190161 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0188861 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.018865 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0187895 |
| NEK10 | NIMA-related kinase 10 | -0.0187813 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0187578 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0186682 |
| CCND1 | cyclin D1 | -0.0181587 |
| FUS | FUS RNA binding protein | -0.0181567 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0178497 |
| SCFD2 | sec1 family domain containing 2 | -0.0177427 |
| TENM3 | teneurin transmembrane protein 3 | -0.0174585 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0173688 |
| FBXO11 | F-box protein 11 | -0.0173241 |
| HLA-B | major histocompatibility complex, class I, B | -0.0172957 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0171954 |
| TRAM1 | translocation associated membrane protein 1 | -0.017191 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0168392 |
| MTDH | metadherin | -0.016827 |
| FNIP1 | folliculin interacting protein 1 | -0.0167709 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0167588 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0166624 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0164861 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.016439 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0164091 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0160009 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0158905 |
| ARF4 | ADP-ribosylation factor 4 | -0.0157056 |
| BRD2 | bromodomain containing 2 | -0.0155928 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.015501 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.015226 |
| DGKI | diacylglycerol kinase, iota | -0.0152134 |
| CCDC80 | coiled-coil domain containing 80 | -0.0150299 |
| PXDN | peroxidasin | -0.0149429 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0148177 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.0145504 |
| PRKCA | protein kinase C, alpha | -0.014521 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0144353 |
| GOLGA4 | golgin A4 | -0.0143721 |
| INTS6 | integrator complex subunit 6 | -0.0143115 |
| SQSTM1 | sequestosome 1 | -0.0142832 |
| TMEM263 | transmembrane protein 263 | -0.0142601 |
