| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.0812905 |
| AHNAK | AHNAK nucleoprotein | 0.0741249 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0723495 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0675602 |
| ACTN4 | actinin, alpha 4 | 0.0650013 |
| OGA | O-GlcNAcase | 0.0626451 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0623282 |
| STK24 | serine/threonine kinase 24 | 0.0615066 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0598989 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0581621 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0527121 |
| RPL4 | ribosomal protein L4 | 0.0513989 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0504244 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0497988 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0494406 |
| RPL23 | ribosomal protein L23 | 0.0493361 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0490472 |
| BCL2L1 | BCL2-like 1 | 0.0486596 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0481401 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0480506 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0475286 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0462031 |
| PTK2 | protein tyrosine kinase 2 | 0.0459948 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0446496 |
| PCBP2 | poly(rC) binding protein 2 | 0.0426824 |
| WWC1 | WW and C2 domain containing 1 | 0.0414546 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0405452 |
| RBM39 | RNA binding motif protein 39 | 0.0405112 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0397291 |
| HYOU1 | hypoxia up-regulated 1 | 0.0393592 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0391794 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0391438 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0388901 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0388428 |
| COG5 | component of oligomeric golgi complex 5 | 0.0380575 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0375618 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0374028 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0371643 |
| ANXA11 | annexin A11 | 0.0369693 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0367393 |
| MSN | moesin | 0.0364661 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0360636 |
| SMAD3 | SMAD family member 3 | 0.0358023 |
| RPS12 | ribosomal protein S12 | 0.0356119 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.035589 |
| PUM2 | pumilio RNA-binding family member 2 | 0.035437 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0352085 |
| FAM135A | family with sequence similarity 135, member A | 0.0350403 |
| RPL3 | ribosomal protein L3 | 0.0346946 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0345893 |
| AFDN | afadin, adherens junction formation factor | 0.034558 |
| TOP1 | topoisomerase (DNA) I | 0.0344335 |
| ATXN1 | ataxin 1 | 0.0342002 |
| NF1 | neurofibromin 1 | 0.0340357 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0337808 |
| RPS17 | ribosomal protein S17 | 0.0336491 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0335226 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.03326 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0330924 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0329732 |
| TES | testin LIM domain protein | 0.0326067 |
| RPS3 | ribosomal protein S3 | 0.0325136 |
| VMP1 | vacuole membrane protein 1 | 0.0321188 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.032033 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0319 |
| NIBAN2 | niban apoptosis regulator 2 | 0.031304 |
| JMJD1C | jumonji domain containing 1C | 0.0312926 |
| ANLN | anillin, actin binding protein | 0.0312711 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0312586 |
| TPM3 | tropomyosin 3 | 0.0310608 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0308476 |
| CENPF | centromere protein F, 350/400kDa | 0.0307149 |
| MED13L | mediator complex subunit 13-like | 0.0305946 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0305075 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0304471 |
| SEPTIN9 | septin 9 | 0.0304272 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0302138 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0300675 |
| RBM33 | RNA binding motif protein 33 | 0.0299501 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0297836 |
| SBF2 | SET binding factor 2 | 0.0296747 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0296402 |
| IPO7 | importin 7 | 0.0293864 |
| NEK7 | NIMA-related kinase 7 | 0.0290471 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0290372 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0289375 |
| USP34 | ubiquitin specific peptidase 34 | 0.0288968 |
| ITGB4 | integrin, beta 4 | 0.028797 |
| TUFT1 | tuftelin 1 | 0.028732 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.028649 |
| VCL | vinculin | 0.0284275 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0283558 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0282783 |
| LATS2 | large tumor suppressor kinase 2 | 0.0282702 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0281179 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0281127 |
| RNF145 | ring finger protein 145 | 0.0278889 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.0275983 |
| AGRN | agrin | 0.0275547 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0275139 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.208018 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.191035 |
| KRT20 | keratin 20, type I | -0.190356 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.178942 |
| FRY | furry homolog (Drosophila) | -0.0996979 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0956069 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0952624 |
| EGR1 | early growth response 1 | -0.0855392 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0749633 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0738314 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0729458 |
| LDHA | lactate dehydrogenase A | -0.0697643 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0668644 |
| JUN | jun proto-oncogene | -0.0646325 |
| PGK1 | phosphoglycerate kinase 1 | -0.0620899 |
| KRT19 | keratin 19, type I | -0.0615133 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0602065 |
| AGR2 | anterior gradient 2 | -0.0587744 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0584975 |
| RPS6 | ribosomal protein S6 | -0.0568694 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0564114 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0563809 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0561908 |
| RPL35A | ribosomal protein L35a | -0.0530253 |
| LMO7 | LIM domain 7 | -0.0509223 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0507143 |
| POF1B | premature ovarian failure, 1B | -0.0493139 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0492758 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0490956 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0483432 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0460739 |
| RNF213 | ring finger protein 213 | -0.0459765 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0459732 |
| TMEM123 | transmembrane protein 123 | -0.0450882 |
| RPLP0 | ribosomal protein, large, P0 | -0.0448436 |
| MMP7 | matrix metallopeptidase 7 | -0.0441486 |
| ACTG1 | actin gamma 1 | -0.044106 |
| EZR | ezrin | -0.0440708 |
| WDR45B | WD repeat domain 45B | -0.0437921 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.043093 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0399931 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0394685 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0389796 |
| TJP1 | tight junction protein 1 | -0.0388515 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0385968 |
| LAMA4 | laminin, alpha 4 | -0.0380884 |
| FBXO32 | F-box protein 32 | -0.0374886 |
| TRIB1 | tribbles pseudokinase 1 | -0.0372958 |
| SQSTM1 | sequestosome 1 | -0.0360278 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | -0.0350758 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0348582 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0337543 |
| EMP1 | epithelial membrane protein 1 | -0.0331351 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0331231 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0329476 |
| FOXO3 | forkhead box O3 | -0.032572 |
| GNAS | GNAS complex locus | -0.0321563 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0317768 |
| TMEM65 | transmembrane protein 65 | -0.0313203 |
| EXPH5 | exophilin 5 | -0.0309944 |
| MUC13 | mucin 13, cell surface associated | -0.0308015 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0303992 |
| AREG | amphiregulin | -0.0303252 |
| LYZ | lysozyme | -0.0302204 |
| B2M | beta-2-microglobulin | -0.0299299 |
| S100A6 | S100 calcium binding protein A6 | -0.0297393 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0297018 |
| S100A10 | S100 calcium binding protein A10 | -0.0295256 |
| RRBP1 | ribosome binding protein 1 | -0.0292946 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0289445 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0285398 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0284901 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0280374 |
| CD63 | CD63 molecule | -0.027986 |
| HMGA1 | high mobility group AT-hook 1 | -0.0277763 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0273448 |
| RPL13A | ribosomal protein L13a | -0.026926 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.026613 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.026575 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.026193 |
| PKM | pyruvate kinase, muscle | -0.0261854 |
| TLE4 | transducin-like enhancer of split 4 | -0.0261735 |
| PCED1B | PC-esterase domain containing 1B | -0.0259013 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0257985 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0255958 |
| DIAPH2 | diaphanous-related formin 2 | -0.0255582 |
| RPS11 | ribosomal protein S11 | -0.0250721 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0249422 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.024636 |
| GSN | gelsolin | -0.0244393 |
| ZFHX3 | zinc finger homeobox 3 | -0.0244012 |
| FBXO11 | F-box protein 11 | -0.0241072 |
| ARF4 | ADP-ribosylation factor 4 | -0.0240255 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0239776 |
| TMEM45B | transmembrane protein 45B | -0.0239179 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0238687 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0238441 |
| SDCBP | syndecan binding protein (syntenin) | -0.0237317 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0237191 |
| MYADM | myeloid-associated differentiation marker | -0.0234675 |
