Ivabradine (hydrochloride)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
C3 complement component 3 0.0974556
LRMDA leucine rich melanocyte differentiation associated 0.06215
APOB apolipoprotein B 0.0448945
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0433867
AFDN afadin, adherens junction formation factor 0.0408134
NKD1 naked cuticle homolog 1 (Drosophila) 0.0390358
ARHGAP9 Rho GTPase activating protein 9 0.0388577
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0383273
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0323401
MYH9 myosin, heavy chain 9, non-muscle 0.0307752
ZMIZ1 zinc finger, MIZ-type containing 1 0.030154
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0300714
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.029937
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0296946
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0273486
TMEM51 transmembrane protein 51 0.0270807
TNS1 tensin 1 0.0268389
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0260382
MSI2 musashi RNA-binding protein 2 0.0252625
RUNX1 runt-related transcription factor 1 0.0248666
KDM3A lysine (K)-specific demethylase 3A 0.024318
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0237747
NFE2L1 nuclear factor, erythroid 2-like 1 0.0225829
MTUS1 microtubule associated tumor suppressor 1 0.0224434
SMAD3 SMAD family member 3 0.0221359
COL7A1 collagen, type VII, alpha 1 0.0218327
PLAC8 placenta-specific 8 0.0214679
GSE1 Gse1 coiled-coil protein 0.0213685
NPAS2 neuronal PAS domain protein 2 0.0208639
IL4R interleukin 4 receptor 0.0205508
MTSS1 metastasis suppressor 1 0.0202496
RBM39 RNA binding motif protein 39 0.0199323
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0198355
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0193431
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.019212
ITGB5 integrin, beta 5 0.0189337
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.018875
DOCK5 dedicator of cytokinesis 5 0.0187864
NRIP1 nuclear receptor interacting protein 1 0.018397
CFB complement factor B 0.0182382
ZFC3H1 zinc finger, C3H1-type containing 0.0177669
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0174945
EIF4B eukaryotic translation initiation factor 4B 0.0174637
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0173318
ERRFI1 ERBB receptor feedback inhibitor 1 0.0171248
SERINC1 serine incorporator 1 0.0170687
TULP4 tubby like protein 4 0.0168552
SPOPL speckle-type POZ protein-like 0.0168522
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0164766
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0162842
RPL4 ribosomal protein L4 0.0161493
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0160109
STRN3 striatin, calmodulin binding protein 3 0.015989
PLEKHA7 pleckstrin homology domain containing, family A member 7 0.015723
ICAM1 intercellular adhesion molecule 1 0.0157191
NPTN neuroplastin 0.0154636
DNAH17 dynein, axonemal, heavy chain 17 0.0153328
ABTB3 ankyrin repeat and BTB domain containing 3 0.0150234
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0148901
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.0147271
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.014343
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0141114
PRELID2 PRELI domain containing 2 0.0140507
SET SET nuclear proto-oncogene 0.0138406
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0136127
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0135824
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0135298
CYTH1 cytohesin 1 0.0133685
CDHR2 cadherin-related family member 2 0.0133504
IGF2R insulin-like growth factor 2 receptor 0.0132295
TRIM33 tripartite motif containing 33 0.0131772
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0131601
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0131248
SOCS5 suppressor of cytokine signaling 5 0.0131199
KANSL3 KAT8 regulatory NSL complex subunit 3 0.0130839
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0130724
IGF1R insulin-like growth factor 1 receptor 0.0129218
WAC WW domain containing adaptor with coiled-coil 0.0127508
ARHGAP17 Rho GTPase activating protein 17 0.0126476
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0125242
ENKUR enkurin, TRPC channel interacting protein 0.0124805
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0124511
DENND5A DENN/MADD domain containing 5A 0.0123802
SDC4 syndecan 4 0.0123336
CEP250 centrosomal protein 250kDa 0.012324
CLTB clathrin, light chain B 0.0123055
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0122781
AGFG1 ArfGAP with FG repeats 1 0.0121314
ELP2 elongator acetyltransferase complex subunit 2 0.0119015
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.0118224
HSPA12A heat shock 70kDa protein 12A 0.011804
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0117011
SAMD4A sterile alpha motif domain containing 4A 0.0116016
SF1 splicing factor 1 0.0115975
ASXL1 additional sex combs like transcriptional regulator 1 0.0115416
ABI1 abl-interactor 1 0.0115082
BHLHE40 basic helix-loop-helix family, member e40 0.0114778
CRLS1 cardiolipin synthase 1 0.0114274
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0113299
NMT2 N-myristoyltransferase 2 0.011308

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.465395
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194505
AKAP12 A kinase (PRKA) anchor protein 12 -0.185461
IGF2 insulin-like growth factor 2 -0.173569
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.165847
MT2A metallothionein 2A -0.129421
FTL ferritin, light polypeptide -0.123067
APOA2 apolipoprotein A-II -0.112763
RPS6 ribosomal protein S6 -0.109815
TPT1 tumor protein, translationally-controlled 1 -0.0949266
AHSG alpha-2-HS-glycoprotein -0.0940235
SLC38A2 solute carrier family 38, member 2 -0.0935137
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0893567
FBF1 Fas (TNFRSF6) binding factor 1 -0.086707
RPLP0 ribosomal protein, large, P0 -0.0859902
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0831682
EHBP1 EH domain binding protein 1 -0.0795795
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0791458
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0727832
RPS8 ribosomal protein S8 -0.0727537
TMSB10 thymosin beta 10 -0.0725968
ENO1 enolase 1, (alpha) -0.0701801
HMGA1 high mobility group AT-hook 1 -0.0677816
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0645486
PLIN2 perilipin 2 -0.0642296
RPS24 ribosomal protein S24 -0.0622899
CCL20 chemokine (C-C motif) ligand 20 -0.060016
RPL35A ribosomal protein L35a -0.0596477
GMDS GDP-mannose 4,6-dehydratase -0.0574668
ASPH aspartate beta-hydroxylase -0.05743
RPL34 ribosomal protein L34 -0.0573668
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0566861
ZBTB20 zinc finger and BTB domain containing 20 -0.0563738
RPS5 ribosomal protein S5 -0.055435
EXT1 exostosin glycosyltransferase 1 -0.0548086
IGFBP1 insulin-like growth factor binding protein 1 -0.0522235
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0507213
RPS14 ribosomal protein S14 -0.0496057
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0489987
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0488418
PDIA3 protein disulfide isomerase family A, member 3 -0.0477253
MBNL2 muscleblind-like splicing regulator 2 -0.0477119
RACK1 receptor for activated C kinase 1 -0.0463117
GPC6 glypican 6 -0.0458056
UBC ubiquitin C -0.0453208
RPL32 ribosomal protein L32 -0.0451069
RPL11 ribosomal protein L11 -0.0442679
SVIL supervillin -0.0442022
NDRG1 N-myc downstream regulated 1 -0.0440805
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0438152
RPL12 ribosomal protein L12 -0.041526
TMEM123 transmembrane protein 123 -0.0399632
RPLP1 ribosomal protein, large, P1 -0.0393237
RPL23 ribosomal protein L23 -0.0390644
LYZ lysozyme -0.0385546
RPS23 ribosomal protein S23 -0.0383808
RPS25 ribosomal protein S25 -0.0382338
PTMA prothymosin, alpha -0.0381578
CANX calnexin -0.038156
GOLGA4 golgin A4 -0.0380588
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0378391
A2M alpha-2-macroglobulin -0.0376743
FAM107B family with sequence similarity 107, member B -0.0376711
TRAM1 translocation associated membrane protein 1 -0.037387
RPL8 ribosomal protein L8 -0.0371549
CP ceruloplasmin (ferroxidase) -0.036641
TM4SF1 transmembrane 4 L six family member 1 -0.0362189
RPS13 ribosomal protein S13 -0.0360637
EGR1 early growth response 1 -0.0359329
DSPP dentin sialophosphoprotein -0.0356698
LOC112694756 uncharaterized LOC112694756 -0.0353643
RPL31 ribosomal protein L31 -0.0352396
RPL5 ribosomal protein L5 -0.035237
RPLP2 ribosomal protein, large, P2 -0.0349548
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0348407
RPS19 ribosomal protein S19 -0.0345845
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0343624
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0337907
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0337071
RPL27A ribosomal protein L27a -0.0334591
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0333358
FRMD5 FERM domain containing 5 -0.0328148
APOA1 apolipoprotein A-I -0.0327954
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0327631
LDHA lactate dehydrogenase A -0.0326974
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.032449
DST dystonin -0.0322078
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0319485
GNAS GNAS complex locus -0.0319466
KLF6 Kruppel-like factor 6 -0.0318689
P4HB prolyl 4-hydroxylase, beta polypeptide -0.031818
PTCHD4 patched domain containing 4 -0.0316669
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0316083
AMBP alpha-1-microglobulin/bikunin precursor -0.0314036
FOXP1 forkhead box P1 -0.0313713
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0313228
PDLIM5 PDZ and LIM domain 5 -0.0310196
RPS21 ribosomal protein S21 -0.0309609
RPS12 ribosomal protein S12 -0.0306625
RPL37A ribosomal protein L37a -0.0306027