Ivabradine (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0743914
NALF1 NALCN channel auxiliary factor 1 0.0675755
COL5A1 collagen, type V, alpha 1 0.0636202
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0597491
SLC12A8 solute carrier family 12, member 8 0.0585934
ZNF841 zinc finger protein 841 0.0562922
MYH9 myosin, heavy chain 9, non-muscle 0.0523928
DST dystonin 0.0520727
FLNB filamin B, beta 0.0503064
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0463034
FNDC3B fibronectin type III domain containing 3B 0.0440032
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0412364
ASPH aspartate beta-hydroxylase 0.0392257
NAV2 neuron navigator 2 0.0384831
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0383602
AHNAK AHNAK nucleoprotein 0.0376147
TRIO trio Rho guanine nucleotide exchange factor 0.0308218
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0301166
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0301046
SDK1 sidekick cell adhesion molecule 1 0.0292519
EGFR epidermal growth factor receptor 0.0272335
COL7A1 collagen, type VII, alpha 1 0.0269626
CD44 CD44 molecule (Indian blood group) 0.0266754
PHACTR1 phosphatase and actin regulator 1 0.0248956
ZEB2 zinc finger E-box binding homeobox 2 0.0245014
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0241875
MSN moesin 0.0237651
TPM3 tropomyosin 3 0.0237391
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0236688
MACF1 microtubule-actin crosslinking factor 1 0.0236471
PRELID2 PRELI domain containing 2 0.0236166
CCDC14 coiled-coil domain containing 14 0.0235315
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0228054
SULF1 sulfatase 1 0.0221342
UBA6 ubiquitin-like modifier activating enzyme 6 0.0216025
RAD51B RAD51 paralog B 0.0215766
LIMCH1 LIM and calponin homology domains 1 0.0211671
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0210863
SAMD4A sterile alpha motif domain containing 4A 0.0209704
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0204859
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0203169
ADARB1 adenosine deaminase, RNA-specific, B1 0.0202516
SMAD3 SMAD family member 3 0.02015
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0195709
LRMDA leucine rich melanocyte differentiation associated 0.0192001
MCL1 myeloid cell leukemia 1 0.0190002
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0188458
SBF2 SET binding factor 2 0.0183354
ERBIN erbb2 interacting protein 0.018271
ANKRD36 ankyrin repeat domain 36 0.0181396
AXL AXL receptor tyrosine kinase 0.0181383
MAML2 mastermind-like 2 (Drosophila) 0.0180582
EXT1 exostosin glycosyltransferase 1 0.0179641
RAI14 retinoic acid induced 14 0.0175039
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0173095
NRIP1 nuclear receptor interacting protein 1 0.0170297
DOCK5 dedicator of cytokinesis 5 0.0169833
NAV1 neuron navigator 1 0.0169702
FAT1 FAT atypical cadherin 1 0.0168966
PICALM phosphatidylinositol binding clathrin assembly protein 0.0166823
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0164692
FAM219A family with sequence similarity 219, member A 0.0163654
VMP1 vacuole membrane protein 1 0.0160761
ATXN1 ataxin 1 0.0158873
SFPQ splicing factor proline/glutamine-rich 0.0158589
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0158429
AFAP1 actin filament associated protein 1 0.015531
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0155259
ZBTB20 zinc finger and BTB domain containing 20 0.0155125
DIAPH3 diaphanous-related formin 3 0.015456
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0152926
FNIP1 folliculin interacting protein 1 0.0151695
TPM1 tropomyosin 1 (alpha) 0.0151181
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0150981
NCOR2 nuclear receptor corepressor 2 0.0148971
CREB1 cAMP responsive element binding protein 1 0.0147629
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0147555
AKAP12 A kinase (PRKA) anchor protein 12 0.0141875
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0141525
OSMR oncostatin M receptor 0.0139841
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.013939
FHIT fragile histidine triad 0.0139338
CDK19 cyclin-dependent kinase 19 0.0139151
LUZP1 leucine zipper protein 1 0.0138963
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0138673
TBC1D5 TBC1 domain family, member 5 0.0136866
NIBAN2 niban apoptosis regulator 2 0.0134852
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0134622
RUNX1 runt-related transcription factor 1 0.013428
GLIS3 GLIS family zinc finger 3 0.0133158
PCBP2 poly(rC) binding protein 2 0.0131712
WWOX WW domain containing oxidoreductase 0.0131544
ATP13A3 ATPase type 13A3 0.0129833
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0129687
RPL3 ribosomal protein L3 0.0129667
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.0129123
ENO1 enolase 1, (alpha) 0.012812
MYOF myoferlin 0.0126911
JARID2 jumonji, AT rich interactive domain 2 0.0126079
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0125836

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.338724
FTL ferritin, light polypeptide -0.312761
HLA-B major histocompatibility complex, class I, B -0.245519
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.185296
MT2A metallothionein 2A -0.13906
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.114583
DEK DEK proto-oncogene -0.0991078
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0892791
RPS6 ribosomal protein S6 -0.0800585
RPL35A ribosomal protein L35a -0.079938
TPT1 tumor protein, translationally-controlled 1 -0.077444
B2M beta-2-microglobulin -0.0768304
FTH1 ferritin, heavy polypeptide 1 -0.0749175
NDRG1 N-myc downstream regulated 1 -0.0748484
ADM adrenomedullin -0.0730796
UGCG UDP-glucose ceramide glucosyltransferase -0.0721826
TMSB10 thymosin beta 10 -0.0718978
MT1X metallothionein 1X -0.0712444
PTMA prothymosin, alpha -0.0684672
IGFBP3 insulin-like growth factor binding protein 3 -0.065087
PDIA3 protein disulfide isomerase family A, member 3 -0.0628266
GNAS GNAS complex locus -0.0612054
CTSD cathepsin D -0.0563778
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0555458
LOC112694756 uncharaterized LOC112694756 -0.054778
PGK1 phosphoglycerate kinase 1 -0.0542066
GOLGA4 golgin A4 -0.0540556
RPL12 ribosomal protein L12 -0.0532285
HMGB1 high mobility group box 1 -0.0525
LDHA lactate dehydrogenase A -0.0517236
ANXA2 annexin A2 -0.0503387
RPLP2 ribosomal protein, large, P2 -0.0500548
IFITM3 interferon induced transmembrane protein 3 -0.0495655
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0491802
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0487285
S100A10 S100 calcium binding protein A10 -0.0486419
WSB1 WD repeat and SOCS box containing 1 -0.0482513
HLA-E major histocompatibility complex, class I, E -0.0477189
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0446728
VDAC1 voltage-dependent anion channel 1 -0.044134
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.043288
EIF1 eukaryotic translation initiation factor 1 -0.0426909
CAVIN1 caveolae associated protein 1 -0.0418209
LMAN1 lectin, mannose-binding, 1 -0.0405729
HLA-A major histocompatibility complex, class I, A -0.0400797
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.039708
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0393353
RPS13 ribosomal protein S13 -0.0391251
JUN jun proto-oncogene -0.0389551
TSC22D2 TSC22 domain family, member 2 -0.0387763
UBC ubiquitin C -0.0384237
RAD21 RAD21 homolog (S. pombe) -0.0382296
RPLP1 ribosomal protein, large, P1 -0.0382082
IER3 immediate early response 3 -0.0375656
CALR calreticulin -0.0370764
TUBB tubulin, beta class I -0.0369756
RPL11 ribosomal protein L11 -0.0369151
SPAG9 sperm associated antigen 9 -0.0365385
RPS8 ribosomal protein S8 -0.036242
MTDH metadherin -0.0360163
SOD2 superoxide dismutase 2, mitochondrial -0.0356555
HMGB2 high mobility group box 2 -0.035138
PFN1 profilin 1 -0.0346678
IFI6 interferon, alpha-inducible protein 6 -0.0345148
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0344952
STAU1 staufen double-stranded RNA binding protein 1 -0.034379
RPL35 ribosomal protein L35 -0.0343223
RPL8 ribosomal protein L8 -0.0340151
VIM vimentin -0.0338596
CANX calnexin -0.0338072
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0337368
RPL37 ribosomal protein L37 -0.0333977
MORF4L2 mortality factor 4 like 2 -0.0327403
FUS FUS RNA binding protein -0.0325955
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.032555
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0322126
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0321735
RPL32 ribosomal protein L32 -0.0315199
WDR45B WD repeat domain 45B -0.0312017
S100A6 S100 calcium binding protein A6 -0.0311325
SQSTM1 sequestosome 1 -0.0309067
RPL34 ribosomal protein L34 -0.0307789
LMNA lamin A/C -0.0307114
RPL28 ribosomal protein L28 -0.0304568
ARF1 ADP-ribosylation factor 1 -0.030438
HILPDA hypoxia inducible lipid droplet-associated -0.0304214
NOP58 NOP58 ribonucleoprotein -0.0301718
RIOK3 RIO kinase 3 -0.0297434
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0295037
RPL27A ribosomal protein L27a -0.0293946
RLF rearranged L-myc fusion -0.029224
RAB7A RAB7A, member RAS oncogene family -0.0287872
RPS19 ribosomal protein S19 -0.0286862
QKI QKI, KH domain containing, RNA binding -0.0286578
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0286544
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0284218
KPNB1 karyopherin (importin) beta 1 -0.0278233
SEPTIN7 septin 7 -0.0277821
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0276224
NUP58 nucleoporin 58 -0.0275965