| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNA5 | ephrin-A5 | 0.0625466 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0599482 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0559561 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0555638 |
| FLNA | filamin A, alpha | 0.0512543 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.050642 |
| ACTG1 | actin gamma 1 | 0.0482137 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0473377 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0450197 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0414597 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0391128 |
| ENKUR | enkurin, TRPC channel interacting protein | 0.0378937 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0373206 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0370557 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0368284 |
| CALD1 | caldesmon 1 | 0.0353957 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0341723 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0340177 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0335494 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0319163 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0316424 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0314947 |
| MSN | moesin | 0.0314005 |
| MED13L | mediator complex subunit 13-like | 0.0309973 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0306081 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0300823 |
| RUNX1 | runt-related transcription factor 1 | 0.0300612 |
| CD163L1 | CD163 molecule-like 1 | 0.0297132 |
| MT2A | metallothionein 2A | 0.0296912 |
| BRD2 | bromodomain containing 2 | 0.0294056 |
| PKM | pyruvate kinase, muscle | 0.0287665 |
| SATB2 | SATB homeobox 2 | 0.0282531 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0282383 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0274466 |
| FRMD6 | FERM domain containing 6 | 0.0273694 |
| USP34 | ubiquitin specific peptidase 34 | 0.0267484 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0265882 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.024966 |
| WDR26 | WD repeat domain 26 | 0.0247946 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.02473 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0236224 |
| ACTN1 | actinin, alpha 1 | 0.0230038 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0229634 |
| HDAC9 | histone deacetylase 9 | 0.0228293 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0226302 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0222373 |
| TLE4 | transducin-like enhancer of split 4 | 0.0221971 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0221467 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0219282 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0213217 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0212499 |
| RPL3 | ribosomal protein L3 | 0.021195 |
| YEATS2 | YEATS domain containing 2 | 0.0211584 |
| RPL37A | ribosomal protein L37a | 0.0211464 |
| BDNF | brain-derived neurotrophic factor | 0.0211423 |
| ATP13A3 | ATPase type 13A3 | 0.0209221 |
| SMG6 | SMG6 nonsense mediated mRNA decay factor | 0.0208857 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0207155 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0205749 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0205545 |
| RPL4 | ribosomal protein L4 | 0.0203709 |
| MCL1 | myeloid cell leukemia 1 | 0.0203477 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0202515 |
| SMAD3 | SMAD family member 3 | 0.0202386 |
| YAP1 | Yes-associated protein 1 | 0.0199974 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0197331 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0196167 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0194139 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0190621 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0184624 |
| HMGA2 | high mobility group AT-hook 2 | 0.0184423 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0183607 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0182282 |
| KLC1 | kinesin light chain 1 | 0.0180125 |
| PCBP2 | poly(rC) binding protein 2 | 0.0178951 |
| RPS2 | ribosomal protein S2 | 0.0177647 |
| CDK19 | cyclin-dependent kinase 19 | 0.0177334 |
| CCN2 | cellular communication network factor 2 | 0.0177175 |
| PRKCE | protein kinase C, epsilon | 0.0174435 |
| SET | SET nuclear proto-oncogene | 0.0172797 |
| FOSL2 | FOS-like antigen 2 | 0.0172731 |
| LOXL2 | lysyl oxidase-like 2 | 0.0171496 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0171253 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0170611 |
| VGF | VGF nerve growth factor inducible | 0.017054 |
| PLEC | plectin | 0.0168907 |
| RPS12 | ribosomal protein S12 | 0.0165942 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0163406 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0162465 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0162219 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0158613 |
| DSCAM | Down syndrome cell adhesion molecule | 0.015339 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0152243 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0151679 |
| VCL | vinculin | 0.0151096 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0151025 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0150919 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0150686 |
| CCDC88A | coiled-coil domain containing 88A | 0.0148995 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0148332 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.2758 |
| VIM | vimentin | -0.223447 |
| RPS6 | ribosomal protein S6 | -0.134707 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.129736 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.125516 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.124178 |
| TMSB10 | thymosin beta 10 | -0.123096 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0990285 |
| LSAMP | limbic system-associated membrane protein | -0.0924751 |
| FTL | ferritin, light polypeptide | -0.0814683 |
| PTMA | prothymosin, alpha | -0.0694405 |
| RPS24 | ribosomal protein S24 | -0.0598637 |
| RPL35A | ribosomal protein L35a | -0.0582403 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0563712 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0548414 |
| CANX | calnexin | -0.054649 |
| H1-0 | H1.0 linker histone | -0.0543417 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0530708 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0525684 |
| RPLP0 | ribosomal protein, large, P0 | -0.050995 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0478951 |
| RPL8 | ribosomal protein L8 | -0.0449392 |
| PTK2 | protein tyrosine kinase 2 | -0.0448319 |
| RPL12 | ribosomal protein L12 | -0.0446122 |
| RLF | rearranged L-myc fusion | -0.0442093 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0426789 |
| EGR1 | early growth response 1 | -0.0420869 |
| IER3 | immediate early response 3 | -0.0415193 |
| RPS8 | ribosomal protein S8 | -0.0410636 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0408394 |
| RPL34 | ribosomal protein L34 | -0.039601 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0395763 |
| MAP4 | microtubule-associated protein 4 | -0.0387499 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0387438 |
| RAD21 | RAD21 homolog (S. pombe) | -0.037986 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0368249 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0366192 |
| TPM4 | tropomyosin 4 | -0.0363712 |
| USP3 | ubiquitin specific peptidase 3 | -0.0357742 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.035709 |
| CDH13 | cadherin 13 | -0.035249 |
| UBC | ubiquitin C | -0.0351561 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0347085 |
| PARD3 | par-3 family cell polarity regulator | -0.0345461 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0333406 |
| RPS25 | ribosomal protein S25 | -0.0326307 |
| TMEM123 | transmembrane protein 123 | -0.0319282 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0317027 |
| TMEM263 | transmembrane protein 263 | -0.0315115 |
| SBF2 | SET binding factor 2 | -0.0314429 |
| RPL36A | ribosomal protein L36a | -0.0313393 |
| QKI | QKI, KH domain containing, RNA binding | -0.0313087 |
| RPL23 | ribosomal protein L23 | -0.0309627 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0309205 |
| RPL32 | ribosomal protein L32 | -0.0308311 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0308264 |
| HMGA1 | high mobility group AT-hook 1 | -0.0308083 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0305115 |
| DEK | DEK proto-oncogene | -0.0304597 |
| HMGB1 | high mobility group box 1 | -0.0301781 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0299973 |
| RTN4 | reticulon 4 | -0.0299902 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0298562 |
| RPS13 | ribosomal protein S13 | -0.0298412 |
| RYBP | RING1 and YY1 binding protein | -0.0296356 |
| RPL11 | ribosomal protein L11 | -0.0295576 |
| GNAS | GNAS complex locus | -0.0293315 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0290542 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.029034 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0288932 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.028822 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0285157 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0281103 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0277413 |
| RPS5 | ribosomal protein S5 | -0.0274611 |
| RPL19 | ribosomal protein L19 | -0.027294 |
| TAOK1 | TAO kinase 1 | -0.0271051 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.027023 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0268442 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0268402 |
| RPLP2 | ribosomal protein, large, P2 | -0.0266785 |
| RPL31 | ribosomal protein L31 | -0.025788 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0254273 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0252775 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0251471 |
| JUN | jun proto-oncogene | -0.025109 |
| FBXO11 | F-box protein 11 | -0.0249697 |
| CDK17 | cyclin-dependent kinase 17 | -0.0247345 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0242225 |
| RPS16 | ribosomal protein S16 | -0.0241907 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0241312 |
| FAM162A | family with sequence similarity 162, member A | -0.0241195 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0234927 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0234494 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0234053 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0232858 |
| RPL38 | ribosomal protein L38 | -0.0232814 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.023237 |
| TEX14 | testis expressed 14 | -0.0228234 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0228042 |
