| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ivabradine (hydrochloride)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.220517 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.110013 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0995265 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0906591 |
| AHNAK | AHNAK nucleoprotein | 0.0845789 |
| ITGA6 | integrin, alpha 6 | 0.0837036 |
| RPL3 | ribosomal protein L3 | 0.0784844 |
| DSPP | dentin sialophosphoprotein | 0.0729122 |
| VEGFA | vascular endothelial growth factor A | 0.0662464 |
| ENO1 | enolase 1, (alpha) | 0.0662053 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.058582 |
| POTEF | POTE ankyrin domain family, member F | 0.0564244 |
| FAT1 | FAT atypical cadherin 1 | 0.0548024 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0543433 |
| PCBP2 | poly(rC) binding protein 2 | 0.0512954 |
| RPS12 | ribosomal protein S12 | 0.0500346 |
| EZR | ezrin | 0.0499603 |
| TPM3 | tropomyosin 3 | 0.0467103 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0455068 |
| YBX1 | Y box binding protein 1 | 0.0447478 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0438072 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.043531 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0429168 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0426273 |
| FAM13A | family with sequence similarity 13, member A | 0.0402249 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0396743 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0385753 |
| MCL1 | myeloid cell leukemia 1 | 0.036621 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0360759 |
| FLNB | filamin B, beta | 0.0352188 |
| CCNY | cyclin Y | 0.0351179 |
| RPS3 | ribosomal protein S3 | 0.0349611 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0347223 |
| SET | SET nuclear proto-oncogene | 0.0343321 |
| KRT8 | keratin 8, type II | 0.0343254 |
| CALR | calreticulin | 0.0335083 |
| VMP1 | vacuole membrane protein 1 | 0.033162 |
| RPL4 | ribosomal protein L4 | 0.0316311 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0314645 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0311674 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0306659 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0306448 |
| HSPA8 | heat shock 70kDa protein 8 | 0.030126 |
| TNS4 | tensin 4 | 0.0297975 |
| DIAPH1 | diaphanous-related formin 1 | 0.0297575 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0295907 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0295204 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0292322 |
| ACTG1 | actin gamma 1 | 0.0289698 |
| ASPH | aspartate beta-hydroxylase | 0.0287967 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0287081 |
| TPM4 | tropomyosin 4 | 0.0280492 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.0275413 |
| ABHD2 | abhydrolase domain containing 2 | 0.0270803 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0267102 |
| SSR1 | signal sequence receptor, alpha | 0.0264953 |
| EREG | epiregulin | 0.0262833 |
| HYOU1 | hypoxia up-regulated 1 | 0.0262262 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0260297 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0259741 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0259253 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0258858 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0255495 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0255355 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0253508 |
| RPS17 | ribosomal protein S17 | 0.0250532 |
| PTEN | phosphatase and tensin homolog | 0.0249277 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0247172 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0244722 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0243014 |
| PNN | pinin, desmosome associated protein | 0.0242929 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0235038 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0233331 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0231661 |
| PCM1 | pericentriolar material 1 | 0.0231311 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.023098 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0223101 |
| CENPF | centromere protein F, 350/400kDa | 0.0223098 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0222242 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.022188 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0221672 |
| ITGB4 | integrin, beta 4 | 0.0216553 |
| MLEC | malectin | 0.021434 |
| RPL37A | ribosomal protein L37a | 0.0212402 |
| ZNF638 | zinc finger protein 638 | 0.0207913 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0207745 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0206767 |
| KIF16B | kinesin family member 16B | 0.020627 |
| CCNC | cyclin C | 0.02048 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.020277 |
| AFDN | afadin, adherens junction formation factor | 0.020257 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0201976 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0201521 |
| GOLGB1 | golgin B1 | 0.0199754 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0197523 |
| RPS7 | ribosomal protein S7 | 0.0196322 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.0196036 |
| CD47 | CD47 molecule | 0.0195363 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.019531 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0193428 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.398557 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.16423 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.110377 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0902158 |
| H1-0 | H1.0 linker histone | -0.0780401 |
| RPS6 | ribosomal protein S6 | -0.0764049 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0673846 |
| RPL35A | ribosomal protein L35a | -0.0627106 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0623495 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0606475 |
| PGK1 | phosphoglycerate kinase 1 | -0.0585598 |
| AGR2 | anterior gradient 2 | -0.0563573 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0561479 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0561346 |
| CD44 | CD44 molecule (Indian blood group) | -0.0545025 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0522332 |
| RPL34 | ribosomal protein L34 | -0.0511372 |
| RPS24 | ribosomal protein S24 | -0.0507254 |
| HMGA1 | high mobility group AT-hook 1 | -0.0504909 |
| NDRG1 | N-myc downstream regulated 1 | -0.0494667 |
| MYO1E | myosin IE | -0.0486547 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0448381 |
| NPSR1 | neuropeptide S receptor 1 | -0.0442319 |
| RPL8 | ribosomal protein L8 | -0.040479 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0398366 |
| RPLP0 | ribosomal protein, large, P0 | -0.0367433 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0364751 |
| LDHA | lactate dehydrogenase A | -0.0361326 |
| RPLP1 | ribosomal protein, large, P1 | -0.0359884 |
| TRIM2 | tripartite motif containing 2 | -0.0353145 |
| ARF1 | ADP-ribosylation factor 1 | -0.0350904 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0344232 |
| RPL12 | ribosomal protein L12 | -0.0334744 |
| PIGR | polymeric immunoglobulin receptor | -0.0333807 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0328315 |
| HMGB1 | high mobility group box 1 | -0.0327058 |
| ONECUT3 | one cut homeobox 3 | -0.0325166 |
| RPS21 | ribosomal protein S21 | -0.031772 |
| GNAS | GNAS complex locus | -0.0314405 |
| CCND1 | cyclin D1 | -0.0311773 |
| PRSS3 | protease, serine, 3 | -0.0310965 |
| RPL38 | ribosomal protein L38 | -0.0297636 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0295218 |
| CADPS | Ca++-dependent secretion activator | -0.029511 |
| POF1B | premature ovarian failure, 1B | -0.0291816 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0287392 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0283088 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0280634 |
| CCNI | cyclin I | -0.0280514 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0277891 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0276627 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0271949 |
| PCDHB16 | protocadherin beta 16 | -0.0270721 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0270467 |
| RPS19 | ribosomal protein S19 | -0.0268116 |
| MXD1 | MAX dimerization protein 1 | -0.026402 |
| SHROOM3 | shroom family member 3 | -0.0263228 |
| FUS | FUS RNA binding protein | -0.026044 |
| RRBP1 | ribosome binding protein 1 | -0.0259919 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.025691 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0254578 |
| RPS15 | ribosomal protein S15 | -0.0250923 |
| GDF15 | growth differentiation factor 15 | -0.0250859 |
| RPL27A | ribosomal protein L27a | -0.0250778 |
| HDLBP | high density lipoprotein binding protein | -0.0248388 |
| RPL13A | ribosomal protein L13a | -0.0248108 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0246157 |
| TUBB4B | tubulin, beta 4B class IVb | -0.024523 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.0240432 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0239183 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0238465 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0236137 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0235071 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0234744 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.023352 |
| IER3 | immediate early response 3 | -0.0231283 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0229734 |
| H3-3B | H3.3 histone B | -0.0228689 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0228507 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.022771 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0227182 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0225863 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0224208 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0223935 |
| S100A10 | S100 calcium binding protein A10 | -0.0220434 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.021953 |
| RPS11 | ribosomal protein S11 | -0.021923 |
| NEBL | nebulette | -0.0216508 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0216211 |
| KRT19 | keratin 19, type I | -0.0215198 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0214735 |
| RPS29 | ribosomal protein S29 | -0.0211936 |
| TUBB | tubulin, beta class I | -0.0211421 |
| FTL | ferritin, light polypeptide | -0.0210403 |
| ARFGEF3 | ARFGEF family member 3 | -0.0209603 |
| COG5 | component of oligomeric golgi complex 5 | -0.0207216 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.020167 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0201269 |
| ZNF33A | zinc finger protein 33A | -0.0201175 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0199466 |
