| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS12 | ribosomal protein S12 | 0.140601 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.119777 |
| PTMA | prothymosin, alpha | 0.113497 |
| RPL3 | ribosomal protein L3 | 0.0946437 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0787672 |
| RPL37A | ribosomal protein L37a | 0.0780112 |
| RPS3 | ribosomal protein S3 | 0.0757629 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0663305 |
| POTEF | POTE ankyrin domain family, member F | 0.0623196 |
| DSPP | dentin sialophosphoprotein | 0.0609022 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0605592 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0603799 |
| ENO1 | enolase 1, (alpha) | 0.0603098 |
| RPS17 | ribosomal protein S17 | 0.0582211 |
| PCBP2 | poly(rC) binding protein 2 | 0.0577802 |
| PRELID2 | PRELI domain containing 2 | 0.0565493 |
| EZR | ezrin | 0.055206 |
| RPS8 | ribosomal protein S8 | 0.0519288 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0470568 |
| RPL4 | ribosomal protein L4 | 0.0463 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0456504 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0430751 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0422082 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0401402 |
| RPL31 | ribosomal protein L31 | 0.0383599 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0376084 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0369317 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0364626 |
| RPL37 | ribosomal protein L37 | 0.0352209 |
| RPL23 | ribosomal protein L23 | 0.0350305 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0349382 |
| ACTG1 | actin gamma 1 | 0.033961 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0325946 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0318599 |
| YBX1 | Y box binding protein 1 | 0.0316541 |
| AHNAK | AHNAK nucleoprotein | 0.0311577 |
| RAD51B | RAD51 paralog B | 0.0310832 |
| FRMD5 | FERM domain containing 5 | 0.0298971 |
| SET | SET nuclear proto-oncogene | 0.0298598 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0297372 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0295001 |
| MCL1 | myeloid cell leukemia 1 | 0.0294608 |
| ANXA11 | annexin A11 | 0.0291858 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0291639 |
| RPS27A | ribosomal protein S27a | 0.0283696 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0279979 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0279872 |
| AFDN | afadin, adherens junction formation factor | 0.0279521 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0279113 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0278187 |
| RPLP2 | ribosomal protein, large, P2 | 0.0277028 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0272363 |
| CALR | calreticulin | 0.0268436 |
| RPS7 | ribosomal protein S7 | 0.0266479 |
| TPM3 | tropomyosin 3 | 0.0263667 |
| RPS19 | ribosomal protein S19 | 0.0261341 |
| RPL14 | ribosomal protein L14 | 0.0251977 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0251073 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0248083 |
| ZNF292 | zinc finger protein 292 | 0.0247086 |
| TMSB10 | thymosin beta 10 | 0.0245388 |
| RPL26 | ribosomal protein L26 | 0.0244166 |
| ADD3 | adducin 3 (gamma) | 0.024316 |
| MYO6 | myosin VI | 0.0242191 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0226551 |
| PTEN | phosphatase and tensin homolog | 0.0224718 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0223608 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0222783 |
| MED13L | mediator complex subunit 13-like | 0.0222614 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0213697 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0213338 |
| FHIT | fragile histidine triad | 0.0212371 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0211403 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.021099 |
| SLK | STE20-like kinase | 0.0210595 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0208606 |
| CENPF | centromere protein F, 350/400kDa | 0.0207236 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0206956 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0206717 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0206671 |
| CDC42SE2 | CDC42 small effector 2 | 0.0205026 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0204907 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0201601 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0201386 |
| RPL27 | ribosomal protein L27 | 0.0197751 |
| RPL9 | ribosomal protein L9 | 0.0195929 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0195399 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0192296 |
| CDK19 | cyclin-dependent kinase 19 | 0.0191213 |
| KRT18 | keratin 18, type I | 0.0191211 |
| RNF145 | ring finger protein 145 | 0.0190218 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0189707 |
| KIF16B | kinesin family member 16B | 0.0189099 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.018909 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0187392 |
| ABHD17C | abhydrolase domain containing 17C | 0.0187038 |
| RPS14 | ribosomal protein S14 | 0.0186269 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.018448 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0184147 |
| ITGB4 | integrin, beta 4 | 0.0183142 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.200663 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.168514 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.130348 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.124794 |
| LMO7 | LIM domain 7 | -0.123143 |
| MYO1E | myosin IE | -0.117534 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0828767 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0734671 |
| RPLP0 | ribosomal protein, large, P0 | -0.0733539 |
| TJP1 | tight junction protein 1 | -0.0731725 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0717525 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0652313 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0628777 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0627453 |
| SHROOM3 | shroom family member 3 | -0.0614406 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.058611 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0546289 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.053134 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0516258 |
| RPS6 | ribosomal protein S6 | -0.0514253 |
| OXSR1 | oxidative stress responsive 1 | -0.0513319 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0487534 |
| FLNB | filamin B, beta | -0.0483932 |
| RIGI | RNA sensor RIG-I | -0.0474032 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0466722 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0459086 |
| SP100 | SP100 nuclear antigen | -0.0422669 |
| PALLD | palladin, cytoskeletal associated protein | -0.0421594 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0417278 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0404441 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0402425 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0400049 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0397863 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0393508 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0393012 |
| PLSCR1 | phospholipid scramblase 1 | -0.0391295 |
| VCL | vinculin | -0.0390231 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0389291 |
| TRIM2 | tripartite motif containing 2 | -0.0385834 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0384686 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0374929 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0369809 |
| GDF15 | growth differentiation factor 15 | -0.0362594 |
| RIMKLB | ribosomal modification protein rimK-like family member B | -0.0362201 |
| HDLBP | high density lipoprotein binding protein | -0.0362185 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0357893 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0357648 |
| CCNI | cyclin I | -0.0355362 |
| LAMA4 | laminin, alpha 4 | -0.0354319 |
| CCND2 | cyclin D2 | -0.03532 |
| PRSS3 | protease, serine, 3 | -0.0351887 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.0350892 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0346965 |
| TXNRD1 | thioredoxin reductase 1 | -0.0346587 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0341918 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0341871 |
| TC2N | tandem C2 domains, nuclear | -0.0329475 |
| CLDN4 | claudin 4 | -0.0326194 |
| EGR1 | early growth response 1 | -0.031822 |
| MX2 | MX dynamin-like GTPase 2 | -0.0317282 |
| RNF213 | ring finger protein 213 | -0.0313882 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0311994 |
| SQSTM1 | sequestosome 1 | -0.0310389 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0307973 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0303952 |
| ATF6 | activating transcription factor 6 | -0.0302849 |
| UBC | ubiquitin C | -0.029414 |
| ARF1 | ADP-ribosylation factor 1 | -0.029383 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0293334 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | -0.029102 |
| FBXO11 | F-box protein 11 | -0.0282966 |
| RPL8 | ribosomal protein L8 | -0.0280622 |
| INO80 | INO80 complex subunit | -0.0280174 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0272464 |
| YBX3 | Y box binding protein 3 | -0.0267859 |
| MYO1D | myosin ID | -0.0267364 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0265087 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0264588 |
| TRIM31 | tripartite motif containing 31 | -0.0261874 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0257558 |
| HMGA1 | high mobility group AT-hook 1 | -0.0256997 |
| USP15 | ubiquitin specific peptidase 15 | -0.0253585 |
| BPTF | bromodomain PHD finger transcription factor | -0.0250093 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0249653 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0249615 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0245369 |
| DSG3 | desmoglein 3 | -0.0244276 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.023755 |
| RRBP1 | ribosome binding protein 1 | -0.0235936 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0233592 |
| CCNG1 | cyclin G1 | -0.0233338 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0232827 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.023083 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0228631 |
| TRIM56 | tripartite motif containing 56 | -0.0221855 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0220418 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0218091 |
| RPS16 | ribosomal protein S16 | -0.0217409 |
| NOSTRIN | nitric oxide synthase trafficking | -0.0217272 |
| CUX1 | cut-like homeobox 1 | -0.021724 |
