| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.104063 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0731506 |
| TXNRD1 | thioredoxin reductase 1 | 0.0712158 |
| RAI1 | retinoic acid induced 1 | 0.0566534 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0562831 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0480831 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0421426 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0404819 |
| ANXA1 | annexin A1 | 0.0356025 |
| TMEM41B | transmembrane protein 41B | 0.0330572 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0309297 |
| NUP58 | nucleoporin 58 | 0.0297408 |
| EZR | ezrin | 0.0281501 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0267924 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0255599 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0235993 |
| CANX | calnexin | 0.0225988 |
| DENND5A | DENN/MADD domain containing 5A | 0.0217568 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0217283 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0216549 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0212334 |
| WDR26 | WD repeat domain 26 | 0.0209456 |
| PRRC2C | proline-rich coiled-coil 2C | 0.020916 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.020915 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0203721 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0200805 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0198591 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0195418 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0190532 |
| AHNAK | AHNAK nucleoprotein | 0.0187916 |
| SCFD1 | sec1 family domain containing 1 | 0.0187615 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0187558 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0182811 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0181222 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0179367 |
| ANGPTL4 | angiopoietin-like 4 | 0.0177744 |
| OGA | O-GlcNAcase | 0.0175721 |
| MCL1 | myeloid cell leukemia 1 | 0.0170995 |
| FLNB | filamin B, beta | 0.0170924 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.017036 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0168458 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0164439 |
| ACTN1 | actinin, alpha 1 | 0.0161379 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0161247 |
| COPG1 | coatomer protein complex, subunit gamma 1 | 0.0159334 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0157021 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0155858 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0155532 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0155182 |
| BMERB1 | bMERB domain containing 1 | 0.0152957 |
| FAM13B | family with sequence similarity 13, member B | 0.0152256 |
| CCDC47 | coiled-coil domain containing 47 | 0.0150414 |
| ACTG1 | actin gamma 1 | 0.0147913 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0147868 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0147418 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.014649 |
| SP3 | Sp3 transcription factor | 0.0146156 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0145207 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.014391 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0142889 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0141909 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0141444 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0141026 |
| RTN4 | reticulon 4 | 0.0140775 |
| ERCC1 | excision repair cross-complementation group 1 | 0.0140693 |
| ZFR | zinc finger RNA binding protein | 0.0139886 |
| SQSTM1 | sequestosome 1 | 0.0139696 |
| SPRY4 | sprouty homolog 4 (Drosophila) | 0.0139163 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0139058 |
| TNPO1 | transportin 1 | 0.0137999 |
| JMJD1C | jumonji domain containing 1C | 0.0136362 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0135475 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0134588 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0133968 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0131244 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0129278 |
| ATP13A3 | ATPase type 13A3 | 0.0127249 |
| ABI1 | abl-interactor 1 | 0.0126842 |
| TFRC | transferrin receptor | 0.012684 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0126577 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0126376 |
| PHF21A | PHD finger protein 21A | 0.0125639 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0125554 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.012499 |
| YAP1 | Yes-associated protein 1 | 0.0124587 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0124009 |
| RRM2 | ribonucleotide reductase M2 | 0.0123701 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0123053 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0122435 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0122043 |
| RPN1 | ribophorin I | 0.0121628 |
| NCKAP1 | NCK-associated protein 1 | 0.0120965 |
| MEMO1 | mediator of cell motility 1 | 0.0120951 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0120588 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0119838 |
| ZNF148 | zinc finger protein 148 | 0.0119602 |
| MATR3 | matrin 3 | 0.0119043 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0118519 |
| NBAS | neuroblastoma amplified sequence | 0.0118456 |
| USP34 | ubiquitin specific peptidase 34 | 0.0117849 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.340472 |
| TP63 | tumor protein p63 | -0.195659 |
| CD44 | CD44 molecule (Indian blood group) | -0.193562 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.153047 |
| VIM | vimentin | -0.148443 |
| DST | dystonin | -0.131951 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.129114 |
| TMSB10 | thymosin beta 10 | -0.129082 |
| CADM2 | cell adhesion molecule 2 | -0.121772 |
| HLA-B | major histocompatibility complex, class I, B | -0.108514 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.103857 |
| FTL | ferritin, light polypeptide | -0.103215 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0953927 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.093814 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0829658 |
| TNS3 | tensin 3 | -0.0789896 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0784048 |
| POTEF | POTE ankyrin domain family, member F | -0.077458 |
| MT2A | metallothionein 2A | -0.07132 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0667939 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0648075 |
| RPS19 | ribosomal protein S19 | -0.0640643 |
| HLA-A | major histocompatibility complex, class I, A | -0.0613391 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0594112 |
| RPL31 | ribosomal protein L31 | -0.0592678 |
| RPL28 | ribosomal protein L28 | -0.0579979 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0577583 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0558838 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0558319 |
| RIGI | RNA sensor RIG-I | -0.0553703 |
| EPHA4 | EPH receptor A4 | -0.0548354 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0545419 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0531254 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0527601 |
| RPL36 | ribosomal protein L36 | -0.0504084 |
| PLSCR1 | phospholipid scramblase 1 | -0.049664 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0489773 |
| PTK2 | protein tyrosine kinase 2 | -0.0485697 |
| EFNA5 | ephrin-A5 | -0.048473 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.048268 |
| RNF213 | ring finger protein 213 | -0.0478448 |
| EHBP1 | EH domain binding protein 1 | -0.0472691 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0471336 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0470018 |
| PDE10A | phosphodiesterase 10A | -0.0469506 |
| HMGA1 | high mobility group AT-hook 1 | -0.0467074 |
| CMIP | c-Maf inducing protein | -0.0459659 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0458913 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0453835 |
| RAD51B | RAD51 paralog B | -0.0445418 |
| ECE1 | endothelin converting enzyme 1 | -0.0444691 |
| H1-0 | H1.0 linker histone | -0.0442677 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.043983 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0436281 |
| RPS29 | ribosomal protein S29 | -0.0428572 |
| RUNX1 | runt-related transcription factor 1 | -0.0419405 |
| B2M | beta-2-microglobulin | -0.0418033 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0416984 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0399922 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0394059 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0387681 |
| VCL | vinculin | -0.0387472 |
| RPLP2 | ribosomal protein, large, P2 | -0.0378108 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0372566 |
| RPS13 | ribosomal protein S13 | -0.036996 |
| RPS8 | ribosomal protein S8 | -0.0367202 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0365809 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0360509 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0358255 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0357795 |
| PRELID2 | PRELI domain containing 2 | -0.0357486 |
| EGFR | epidermal growth factor receptor | -0.0350859 |
| RPS25 | ribosomal protein S25 | -0.034831 |
| RPL8 | ribosomal protein L8 | -0.0344887 |
| RPL12 | ribosomal protein L12 | -0.0343822 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0343767 |
| DPH6 | diphthamine biosynthesis 6 | -0.034142 |
| RPS23 | ribosomal protein S23 | -0.033981 |
| RPS5 | ribosomal protein S5 | -0.0334733 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0333275 |
| RPS17 | ribosomal protein S17 | -0.0329299 |
| PFN1 | profilin 1 | -0.0327974 |
| RPL35A | ribosomal protein L35a | -0.0326743 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0326625 |
| RPL37A | ribosomal protein L37a | -0.0326543 |
| RPS6 | ribosomal protein S6 | -0.0325626 |
| PTMA | prothymosin, alpha | -0.0322209 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0318146 |
| SMYD3 | SET and MYND domain containing 3 | -0.0310001 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0309237 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.030755 |
| EGR1 | early growth response 1 | -0.030554 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.030414 |
| TPI1 | triosephosphate isomerase 1 | -0.0302472 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0301922 |
| VMP1 | vacuole membrane protein 1 | -0.0299452 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.029782 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.029632 |
| EXOC4 | exocyst complex component 4 | -0.0293386 |
| RPS27 | ribosomal protein S27 | -0.0292725 |
