| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAM13A | family with sequence similarity 13, member A | 0.132652 |
| ENO1 | enolase 1, (alpha) | 0.0810186 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0741387 |
| ASPH | aspartate beta-hydroxylase | 0.0636658 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0613915 |
| MCL1 | myeloid cell leukemia 1 | 0.0610079 |
| PCBP2 | poly(rC) binding protein 2 | 0.0602503 |
| CPE | carboxypeptidase E | 0.0601935 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.059211 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0584158 |
| RPS3 | ribosomal protein S3 | 0.0528451 |
| PTMA | prothymosin, alpha | 0.0513966 |
| HYOU1 | hypoxia up-regulated 1 | 0.050833 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0489162 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0484262 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0467824 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0450293 |
| GRAMD1B | GRAM domain containing 1B | 0.0449247 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0449043 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0444919 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0443565 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0439718 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0408994 |
| OGA | O-GlcNAcase | 0.0405571 |
| TMEM165 | transmembrane protein 165 | 0.0395951 |
| ZNF292 | zinc finger protein 292 | 0.038896 |
| AHNAK | AHNAK nucleoprotein | 0.0373533 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0368859 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0368208 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0366911 |
| RPL3 | ribosomal protein L3 | 0.0365753 |
| RPL4 | ribosomal protein L4 | 0.0357313 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0356699 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0356327 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0353347 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0352846 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0348098 |
| SMAD3 | SMAD family member 3 | 0.0346719 |
| ARRDC3 | arrestin domain containing 3 | 0.0346248 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0341923 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0340523 |
| RNF145 | ring finger protein 145 | 0.0339483 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0337169 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0335784 |
| HELZ | helicase with zinc finger | 0.0325069 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0321244 |
| PTEN | phosphatase and tensin homolog | 0.0320586 |
| CES1 | carboxylesterase 1 | 0.0320357 |
| PDE8A | phosphodiesterase 8A | 0.0317977 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.03141 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0307846 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0307248 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0301188 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0299976 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0298339 |
| TPD52 | tumor protein D52 | 0.0293796 |
| ZNF148 | zinc finger protein 148 | 0.0292249 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.029134 |
| MYOF | myoferlin | 0.0288046 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0284492 |
| YAP1 | Yes-associated protein 1 | 0.0284448 |
| RNF149 | ring finger protein 149 | 0.0280621 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0278094 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0277396 |
| TPM3 | tropomyosin 3 | 0.0276603 |
| APP | amyloid beta (A4) precursor protein | 0.0274021 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0273971 |
| FNDC3B | fibronectin type III domain containing 3B | 0.026997 |
| SEPTIN2 | septin 2 | 0.0268 |
| NGLY1 | N-glycanase 1 | 0.0263693 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0262429 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0259859 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0259462 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0257791 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0257238 |
| NPTN | neuroplastin | 0.0257236 |
| SLMAP | sarcolemma associated protein | 0.0256259 |
| RBM26 | RNA binding motif protein 26 | 0.025331 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0250437 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0248984 |
| TOP1 | topoisomerase (DNA) I | 0.0248224 |
| KLC1 | kinesin light chain 1 | 0.0248214 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0246914 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0246499 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0245744 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0244802 |
| SRP54 | signal recognition particle 54kDa | 0.0243364 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0242592 |
| UVRAG | UV radiation resistance associated | 0.0241171 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0239938 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.023839 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0237397 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0237317 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0235537 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0234684 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.023459 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0233764 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0231067 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0230382 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0229749 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.458529 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.172909 |
| EGR1 | early growth response 1 | -0.106364 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0762098 |
| H1-0 | H1.0 linker histone | -0.0746528 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0686866 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0666457 |
| OSMR | oncostatin M receptor | -0.0625281 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0619227 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0611954 |
| NABP1 | nucleic acid binding protein 1 | -0.0587256 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0581056 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0577967 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.054833 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0514306 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.047231 |
| TMSB10 | thymosin beta 10 | -0.0424428 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.042408 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0387395 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0377707 |
| NDRG1 | N-myc downstream regulated 1 | -0.0370219 |
| MYO1E | myosin IE | -0.0365856 |
| CCND1 | cyclin D1 | -0.0358525 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0349704 |
| ANXA2 | annexin A2 | -0.0346445 |
| RPL35A | ribosomal protein L35a | -0.0339324 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0332135 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0326519 |
| RAB7A | RAB7A, member RAS oncogene family | -0.032555 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0320051 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0319659 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0308431 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0307377 |
| GM2A | GM2 ganglioside activator | -0.0306834 |
| HMGA1 | high mobility group AT-hook 1 | -0.0298123 |
| RPS6 | ribosomal protein S6 | -0.0286932 |
| S100A10 | S100 calcium binding protein A10 | -0.0285154 |
| EGFR | epidermal growth factor receptor | -0.0283365 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0280611 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0273417 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.026832 |
| TJP1 | tight junction protein 1 | -0.0266064 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0264992 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0261901 |
| INTS6 | integrator complex subunit 6 | -0.0261326 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0261074 |
| ARF1 | ADP-ribosylation factor 1 | -0.0254549 |
| RPS24 | ribosomal protein S24 | -0.0253676 |
| EMP1 | epithelial membrane protein 1 | -0.0251961 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0243681 |
| LDHA | lactate dehydrogenase A | -0.024312 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0237965 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0235262 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0234065 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0229443 |
| SMYD3 | SET and MYND domain containing 3 | -0.0228806 |
| RPL8 | ribosomal protein L8 | -0.021612 |
| TRIM56 | tripartite motif containing 56 | -0.0212995 |
| WASF2 | WAS protein family, member 2 | -0.0211325 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0210377 |
| RNASEH2A | ribonuclease H2, subunit A | -0.0207484 |
| RPL34 | ribosomal protein L34 | -0.0205807 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0205172 |
| EFNA5 | ephrin-A5 | -0.0202648 |
| AREG | amphiregulin | -0.0201013 |
| SPAG9 | sperm associated antigen 9 | -0.0200878 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0200183 |
| IER3 | immediate early response 3 | -0.0199534 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0199485 |
| OXSR1 | oxidative stress responsive 1 | -0.0199417 |
| MORF4L2 | mortality factor 4 like 2 | -0.0197646 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0197532 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0197464 |
| FTL | ferritin, light polypeptide | -0.0193077 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0191867 |
| FUS | FUS RNA binding protein | -0.0191694 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0191537 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.01908 |
| VCL | vinculin | -0.0188676 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0187608 |
| AGR2 | anterior gradient 2 | -0.0186397 |
| HLA-B | major histocompatibility complex, class I, B | -0.0186189 |
| CCNI | cyclin I | -0.0186121 |
| MGAT4C | MGAT4 family, member C | -0.0184667 |
| BPTF | bromodomain PHD finger transcription factor | -0.0183953 |
| RPLP0 | ribosomal protein, large, P0 | -0.0183049 |
| CUX1 | cut-like homeobox 1 | -0.0181872 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0179082 |
| SP100 | SP100 nuclear antigen | -0.0178868 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0177716 |
| RPS25 | ribosomal protein S25 | -0.0177257 |
| FBXO11 | F-box protein 11 | -0.0176302 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0175228 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0175103 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0175093 |
| CBL | Cbl proto-oncogene, E3 ubiquitin protein ligase | -0.017463 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0172086 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0171734 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0171483 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0170621 |
