Ivabradine (hydrochloride)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 0.101037
FAM20C family with sequence similarity 20, member C 0.0778969
SMAD3 SMAD family member 3 0.0717298
PDE4D phosphodiesterase 4D, cAMP-specific 0.0701026
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0667826
NAV2 neuron navigator 2 0.0663265
FNDC3B fibronectin type III domain containing 3B 0.0564732
DOCK5 dedicator of cytokinesis 5 0.0520029
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0461709
PRELID2 PRELI domain containing 2 0.0449547
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0412342
AKAP12 A kinase (PRKA) anchor protein 12 0.0407533
RAD51B RAD51 paralog B 0.0402097
NAMPT nicotinamide phosphoribosyltransferase 0.0401692
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0385514
BACE2 beta-site APP-cleaving enzyme 2 0.0374715
PCBP2 poly(rC) binding protein 2 0.0372651
USP34 ubiquitin specific peptidase 34 0.0370396
EGFR epidermal growth factor receptor 0.0357733
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0357416
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0352443
MCL1 myeloid cell leukemia 1 0.0345926
ETV6 ets variant 6 0.0344562
VEGFA vascular endothelial growth factor A 0.0342439
TGM2 transglutaminase 2 0.0336867
NPC1 Niemann-Pick disease, type C1 0.0307142
MYH9 myosin, heavy chain 9, non-muscle 0.0304562
FAM13A family with sequence similarity 13, member A 0.0302803
ANKRD36 ankyrin repeat domain 36 0.0301345
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0299708
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0297406
LOXL2 lysyl oxidase-like 2 0.0284795
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0283529
CDK19 cyclin-dependent kinase 19 0.0277482
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0269732
RUNX1 runt-related transcription factor 1 0.026598
FLNB filamin B, beta 0.0263042
SDK1 sidekick cell adhesion molecule 1 0.0262685
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0262124
EHBP1 EH domain binding protein 1 0.0260568
RUNX2 runt-related transcription factor 2 0.0258352
GYS1 glycogen synthase 1 (muscle) 0.0244259
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0240781
DSCAM Down syndrome cell adhesion molecule 0.0238486
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0238075
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0235238
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0232593
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0231653
YEATS2 YEATS domain containing 2 0.0231471
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0229331
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.0229205
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0227804
RPL3 ribosomal protein L3 0.0219751
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.021467
DST dystonin 0.0212897
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0208934
NPAS2 neuronal PAS domain protein 2 0.0208765
SKAP2 src kinase associated phosphoprotein 2 0.0206485
ZBTB20 zinc finger and BTB domain containing 20 0.0205908
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0203809
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0202912
NFE2L1 nuclear factor, erythroid 2-like 1 0.0201899
PTEN phosphatase and tensin homolog 0.0200756
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0200319
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0199405
PFKP phosphofructokinase, platelet 0.0198671
XRN1 5'-3' exoribonuclease 1 0.0198014
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.019166
GRB10 growth factor receptor-bound protein 10 0.0190817
RERE arginine-glutamic acid dipeptide (RE) repeats 0.018964
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0188978
EEF2 eukaryotic translation elongation factor 2 0.0188624
CNOT12 CCR4-NOT transcription complex subunit 12 0.018782
NGLY1 N-glycanase 1 0.0187515
SS18 synovial sarcoma translocation, chromosome 18 0.0187077
DPYSL3 dihydropyrimidinase-like 3 0.018599
ATXN1 ataxin 1 0.0184354
FBXL13 F-box and leucine-rich repeat protein 13 0.0183869
HDAC9 histone deacetylase 9 0.0183801
ANTXR2 anthrax toxin receptor 2 0.0181463
CHD1L chromodomain helicase DNA binding protein 1-like 0.0179835
MLPH melanophilin 0.0178918
EXOC4 exocyst complex component 4 0.0178282
TP53BP1 tumor protein p53 binding protein 1 0.0177004
ZNF638 zinc finger protein 638 0.0176523
ADD3 adducin 3 (gamma) 0.01762
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0175963
TBC1D5 TBC1 domain family, member 5 0.0174589
CEP250 centrosomal protein 250kDa 0.0172501
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0171223
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0169607
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.016928
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0167461
GBP2 guanylate binding protein 2, interferon-inducible 0.0165587
MACF1 microtubule-actin crosslinking factor 1 0.0165533
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0165144
HDAC4 histone deacetylase 4 0.0163891
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0162496
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0160967
TBC1D15 TBC1 domain family, member 15 0.0160438

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.337109
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.218481
TMSB10 thymosin beta 10 -0.176088
FTL ferritin, light polypeptide -0.171246
VIM vimentin -0.168008
CXCL8 chemokine (C-X-C motif) ligand 8 -0.118629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.106294
PTMA prothymosin, alpha -0.0975156
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0870397
IER3 immediate early response 3 -0.0867744
RPL35A ribosomal protein L35a -0.0745833
RPS6 ribosomal protein S6 -0.0733765
RAB1A RAB1A, member RAS oncogene family -0.069102
TPT1 tumor protein, translationally-controlled 1 -0.0683218
RPLP1 ribosomal protein, large, P1 -0.0672505
RPS24 ribosomal protein S24 -0.0646162
RPLP0 ribosomal protein, large, P0 -0.0605587
GOLGA4 golgin A4 -0.0601297
STC1 stanniocalcin 1 -0.0598387
RPS19 ribosomal protein S19 -0.0582149
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0551472
KDM3A lysine (K)-specific demethylase 3A -0.0546658
RPL32 ribosomal protein L32 -0.0543675
HMGA1 high mobility group AT-hook 1 -0.0536447
MT2A metallothionein 2A -0.0534664
FN1 fibronectin 1 -0.0534548
RPL34 ribosomal protein L34 -0.0520509
RIOK3 RIO kinase 3 -0.0494295
LMAN1 lectin, mannose-binding, 1 -0.0483191
H1-0 H1.0 linker histone -0.0478802
PDIA3 protein disulfide isomerase family A, member 3 -0.0475602
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0461968
RPS8 ribosomal protein S8 -0.0461807
RPS21 ribosomal protein S21 -0.0458675
EIF1 eukaryotic translation initiation factor 1 -0.0456296
VDAC1 voltage-dependent anion channel 1 -0.0452246
S100A10 S100 calcium binding protein A10 -0.0451577
TFPI2 tissue factor pathway inhibitor 2 -0.0447476
S100A6 S100 calcium binding protein A6 -0.0445451
NAP1L1 nucleosome assembly protein 1-like 1 -0.0439501
RBM39 RNA binding motif protein 39 -0.0438081
TMEM263 transmembrane protein 263 -0.0431194
RPL12 ribosomal protein L12 -0.0427441
SOS1 son of sevenless homolog 1 (Drosophila) -0.0423832
USP3 ubiquitin specific peptidase 3 -0.0418507
GNAS GNAS complex locus -0.0413561
RPLP2 ribosomal protein, large, P2 -0.0408228
CD44 CD44 molecule (Indian blood group) -0.0407561
RPL11 ribosomal protein L11 -0.0406739
RAP1B RAP1B, member of RAS oncogene family -0.04058
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0404743
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0401685
WSB1 WD repeat and SOCS box containing 1 -0.0401523
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0396505
RPS11 ribosomal protein S11 -0.0396464
DDIT3 DNA-damage-inducible transcript 3 -0.0392631
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0389965
RPL23 ribosomal protein L23 -0.0382273
RPS25 ribosomal protein S25 -0.0372773
RPS13 ribosomal protein S13 -0.0363135
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0363114
BTG1 B-cell translocation gene 1, anti-proliferative -0.036157
RAB7A RAB7A, member RAS oncogene family -0.0358782
LGALS1 lectin, galactoside-binding, soluble, 1 -0.035873
RPS29 ribosomal protein S29 -0.0358449
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0357635
CANX calnexin -0.0351358
RPL31 ribosomal protein L31 -0.0348158
RPL38 ribosomal protein L38 -0.0347867
RPS5 ribosomal protein S5 -0.0341888
WAC WW domain containing adaptor with coiled-coil -0.0339463
RPL19 ribosomal protein L19 -0.0337806
RPS23 ribosomal protein S23 -0.033572
UBC ubiquitin C -0.0334362
B2M beta-2-microglobulin -0.0332443
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0330865
RPL36 ribosomal protein L36 -0.0329584
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0328458
C15ORF48 chromosome 15 open reading frame 48 -0.0327202
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0326136
PARD3 par-3 family cell polarity regulator -0.032443
MAP1B microtubule-associated protein 1B -0.0321946
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0316946
RPL28 ribosomal protein L28 -0.0315961
EGR1 early growth response 1 -0.0313225
S100A9 S100 calcium binding protein A9 -0.0307885
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0307881
MARCHF6 membrane associated ring-CH-type finger 6 -0.0302917
SOD2 superoxide dismutase 2, mitochondrial -0.0302395
YBX1 Y box binding protein 1 -0.0300599
HILPDA hypoxia inducible lipid droplet-associated -0.030022
SPAG9 sperm associated antigen 9 -0.0299733
RPS16 ribosomal protein S16 -0.0293936
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.029004
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0286525
GLCCI1 glucocorticoid induced 1 -0.0286294
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0286128
NPEPPS aminopeptidase puromycin sensitive -0.0286044
WDR45B WD repeat domain 45B -0.0285714
NCOA7 nuclear receptor coactivator 7 -0.0280983