Ivabradine (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.211447
TXNRD1 thioredoxin reductase 1 0.120187
AKAP12 A kinase (PRKA) anchor protein 12 0.086118
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0849294
RPL4 ribosomal protein L4 0.0826246
ERRFI1 ERBB receptor feedback inhibitor 1 0.0703238
HSPA8 heat shock 70kDa protein 8 0.0605057
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0587326
ASPH aspartate beta-hydroxylase 0.0574193
FTH1 ferritin, heavy polypeptide 1 0.0538413
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0512438
RPS12 ribosomal protein S12 0.0489246
RPL3 ribosomal protein L3 0.0474397
RPS3 ribosomal protein S3 0.0463584
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0459556
AHNAK AHNAK nucleoprotein 0.0441829
EIF4A1 eukaryotic translation initiation factor 4A1 0.0438987
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0436179
ENO1 enolase 1, (alpha) 0.0426993
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0421009
RPS7 ribosomal protein S7 0.0407704
NAMPT nicotinamide phosphoribosyltransferase 0.0393446
DGKD diacylglycerol kinase, delta 130kDa 0.0391585
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0384186
PTMA prothymosin, alpha 0.0377119
EEF2 eukaryotic translation elongation factor 2 0.0354181
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.034623
TPM3 tropomyosin 3 0.0344226
RPL26 ribosomal protein L26 0.0333209
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0321696
RPS2 ribosomal protein S2 0.0318325
MT2A metallothionein 2A 0.0303479
RPL37A ribosomal protein L37a 0.0303382
APP amyloid beta (A4) precursor protein 0.030326
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0301499
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0298137
TM4SF1 transmembrane 4 L six family member 1 0.028332
RPS4Y1 ribosomal protein S4, Y-linked 1 0.028142
MYH9 myosin, heavy chain 9, non-muscle 0.0277647
RPL23 ribosomal protein L23 0.0276374
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0275181
SDC4 syndecan 4 0.0273892
YAP1 Yes-associated protein 1 0.0272171
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0271197
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0268726
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0262999
WDR43 WD repeat domain 43 0.0257162
FAM168A family with sequence similarity 168, member A 0.0248696
RPS27A ribosomal protein S27a 0.0247056
HDGF hepatoma-derived growth factor 0.0246778
ACTG1 actin gamma 1 0.0245499
NTN4 netrin 4 0.0241068
FGB fibrinogen beta chain 0.0235057
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.023333
S100A6 S100 calcium binding protein A6 0.0231382
THBS1 thrombospondin 1 0.0226043
CXCL8 chemokine (C-X-C motif) ligand 8 0.0224134
BIRC2 baculoviral IAP repeat containing 2 0.0218541
NNMT nicotinamide N-methyltransferase 0.0216733
KLF6 Kruppel-like factor 6 0.0214306
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0211853
BIRC3 baculoviral IAP repeat containing 3 0.0209787
FBL fibrillarin 0.0209358
BZW1 basic leucine zipper and W2 domains 1 0.020921
VMP1 vacuole membrane protein 1 0.0204543
RPS17 ribosomal protein S17 0.0203829
PFDN2 prefoldin subunit 2 0.0200575
BCLAF1 BCL2-associated transcription factor 1 0.0198456
MKI67 marker of proliferation Ki-67 0.0192883
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0192172
HDAC9 histone deacetylase 9 0.0190517
SPAG5 sperm associated antigen 5 0.0190137
CFLAR CASP8 and FADD-like apoptosis regulator 0.0189829
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0189189
UCK2 uridine-cytidine kinase 2 0.0188997
RPL37 ribosomal protein L37 0.0185772
YBX1 Y box binding protein 1 0.0185583
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0184298
CCL2 chemokine (C-C motif) ligand 2 0.0183413
TPM4 tropomyosin 4 0.0182495
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0177556
RPL5 ribosomal protein L5 0.017484
CENPF centromere protein F, 350/400kDa 0.0173948
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0171742
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0171451
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0170707
ILF2 interleukin enhancer binding factor 2 0.0170105
PRDX1 peroxiredoxin 1 0.0166567
TCIM transcriptional and immune response regulator 0.0164309
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0161902
LAMB1 laminin, beta 1 0.0159998
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0158795
MEMO1 mediator of cell motility 1 0.015826
NFE2L2 nuclear factor, erythroid 2-like 2 0.0156868
SET SET nuclear proto-oncogene 0.0156841
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 0.0155799
RPL18 ribosomal protein L18 0.0155436
EIF4H eukaryotic translation initiation factor 4H 0.0155211
ATG5 autophagy related 5 0.0154962
ANGPTL4 angiopoietin-like 4 0.0150414

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.349497
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.120194
THSD4 thrombospondin, type I, domain containing 4 -0.11215
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0913553
FTL ferritin, light polypeptide -0.0893827
FNDC3B fibronectin type III domain containing 3B -0.0817421
TMSB10 thymosin beta 10 -0.0779492
PDE4D phosphodiesterase 4D, cAMP-specific -0.0774978
IGF2 insulin-like growth factor 2 -0.0750534
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0713296
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.070596
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0688626
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0659795
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0610904
COPA coatomer protein complex, subunit alpha -0.0588185
WAC WW domain containing adaptor with coiled-coil -0.0557638
RAB7A RAB7A, member RAS oncogene family -0.0553287
PDIA3 protein disulfide isomerase family A, member 3 -0.0543009
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0539424
DOCK4 dedicator of cytokinesis 4 -0.0538836
EGR1 early growth response 1 -0.0532212
ZFAND3 zinc finger, AN1-type domain 3 -0.0520328
IGFBP3 insulin-like growth factor binding protein 3 -0.0517666
HMGA1 high mobility group AT-hook 1 -0.0507874
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0506168
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0497356
FMNL2 formin-like 2 -0.0492896
ARHGAP26 Rho GTPase activating protein 26 -0.0492199
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0468235
ELL2 elongation factor, RNA polymerase II, 2 -0.0457923
PFN1 profilin 1 -0.0450538
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0450203
FUS FUS RNA binding protein -0.0447708
GLS2 glutaminase 2 (liver, mitochondrial) -0.0437895
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0433981
FOXO3 forkhead box O3 -0.0432337
PARD3 par-3 family cell polarity regulator -0.0423742
TRIO trio Rho guanine nucleotide exchange factor -0.0418967
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0412927
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0412348
RPLP0 ribosomal protein, large, P0 -0.0409608
SPRED2 sprouty-related, EVH1 domain containing 2 -0.040372
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0391152
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0387081
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0380578
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0378373
CCNL1 cyclin L1 -0.037142
SLC38A2 solute carrier family 38, member 2 -0.0366109
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0363717
EXT1 exostosin glycosyltransferase 1 -0.0359987
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0359732
STC1 stanniocalcin 1 -0.0359646
FBXO11 F-box protein 11 -0.0359346
ITCH itchy E3 ubiquitin protein ligase -0.0354151
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0348659
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0341674
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0337603
SMOC1 SPARC related modular calcium binding 1 -0.0332776
SAMD4A sterile alpha motif domain containing 4A -0.0332493
RAB1A RAB1A, member RAS oncogene family -0.0332114
RPS5 ribosomal protein S5 -0.0329163
RPL8 ribosomal protein L8 -0.0325807
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.032231
RPS6 ribosomal protein S6 -0.032093
VDAC1 voltage-dependent anion channel 1 -0.0319282
NEBL nebulette -0.0317769
PRR16 proline rich 16 -0.0310961
PUM2 pumilio RNA-binding family member 2 -0.0304584
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.030435
HMGB1 high mobility group box 1 -0.0300414
NDRG1 N-myc downstream regulated 1 -0.0297594
SPDYA speedy/RINGO cell cycle regulator family member A -0.0294338
RPS15 ribosomal protein S15 -0.029345
TMEM87A transmembrane protein 87A -0.0293382
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0290622
ERBIN erbb2 interacting protein -0.0288062
RBM39 RNA binding motif protein 39 -0.0286416
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0285409
ARF4 ADP-ribosylation factor 4 -0.0284199
TSC22D2 TSC22 domain family, member 2 -0.0283904
UBC ubiquitin C -0.0281888
BIRC6 baculoviral IAP repeat containing 6 -0.0281594
DSCAM Down syndrome cell adhesion molecule -0.0278598
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0276437
BRD2 bromodomain containing 2 -0.0275747
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0274949
MYO1E myosin IE -0.0274047
CHD1 chromodomain helicase DNA binding protein 1 -0.027329
RPL19 ribosomal protein L19 -0.0268844
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0268833
SLC35F3 solute carrier family 35, member F3 -0.0268215
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0265766
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0263351
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0257144
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0256624
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0256406
RPL35A ribosomal protein L35a -0.0255967
ZFHX3 zinc finger homeobox 3 -0.0255308
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0255081
EGFR epidermal growth factor receptor -0.0254541