| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.177483 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.159221 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.125638 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.119845 |
| MCL1 | myeloid cell leukemia 1 | 0.11363 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.105547 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0957258 |
| ATP13A3 | ATPase type 13A3 | 0.0952542 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0813865 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0806878 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0784849 |
| SPAG9 | sperm associated antigen 9 | 0.0782143 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0780472 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0756215 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0747446 |
| SBF2 | SET binding factor 2 | 0.0743416 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0734118 |
| SETD5 | SET domain containing 5 | 0.0722952 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0708616 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0687736 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.06865 |
| GOLGA4 | golgin A4 | 0.0671867 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0657222 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0636727 |
| FAM13A | family with sequence similarity 13, member A | 0.0626397 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0621262 |
| FLNB | filamin B, beta | 0.0616795 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0614667 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0608243 |
| EFNA5 | ephrin-A5 | 0.0602181 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0597176 |
| FNIP1 | folliculin interacting protein 1 | 0.0596073 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0593946 |
| S100P | S100 calcium binding protein P | 0.0592285 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0577255 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0576215 |
| VMP1 | vacuole membrane protein 1 | 0.0575326 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.057099 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0567531 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.055457 |
| ITGB4 | integrin, beta 4 | 0.05529 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | 0.0551673 |
| RPL26 | ribosomal protein L26 | 0.0550526 |
| RUNX1 | runt-related transcription factor 1 | 0.0549135 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0548274 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0540237 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0539512 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0539099 |
| NDRG1 | N-myc downstream regulated 1 | 0.0538609 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0536869 |
| KRT17 | keratin 17, type I | 0.0532311 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0531398 |
| RPL37A | ribosomal protein L37a | 0.0525776 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0525124 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0522326 |
| S100A6 | S100 calcium binding protein A6 | 0.0512103 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0509397 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0507746 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0493569 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0486673 |
| PCBP2 | poly(rC) binding protein 2 | 0.0475247 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.046821 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0458058 |
| HELZ | helicase with zinc finger | 0.0456696 |
| ITGA6 | integrin, alpha 6 | 0.0450105 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0449771 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0446904 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0446738 |
| BPTF | bromodomain PHD finger transcription factor | 0.0442425 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0437204 |
| FTL | ferritin, light polypeptide | 0.0432543 |
| INTS6 | integrator complex subunit 6 | 0.0429888 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0427586 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.042297 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0422738 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0421694 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0419793 |
| FMNL2 | formin-like 2 | 0.041892 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0411767 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | 0.0410153 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0409418 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0407748 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0406158 |
| NF1 | neurofibromin 1 | 0.0405172 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0399347 |
| ABI1 | abl-interactor 1 | 0.0395174 |
| CCND1 | cyclin D1 | 0.0383241 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0379986 |
| STC1 | stanniocalcin 1 | 0.0374805 |
| ZNF292 | zinc finger protein 292 | 0.0370505 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0370285 |
| HDLBP | high density lipoprotein binding protein | 0.0366189 |
| PTGES2 | prostaglandin E synthase 2 | 0.0360487 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0357109 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0356789 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0353522 |
| RPS24 | ribosomal protein S24 | 0.0352637 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0352024 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0344141 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0340869 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.1502 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.124544 |
| EGFR | epidermal growth factor receptor | -0.117174 |
| SLTM | SAFB-like, transcription modulator | -0.103571 |
| DPYD | dihydropyrimidine dehydrogenase | -0.101037 |
| MT2A | metallothionein 2A | -0.0995424 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0995362 |
| TMEM165 | transmembrane protein 165 | -0.0927597 |
| CD44 | CD44 molecule (Indian blood group) | -0.0919834 |
| LMO7 | LIM domain 7 | -0.0916206 |
| B2M | beta-2-microglobulin | -0.0897704 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0886615 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.085414 |
| VIM | vimentin | -0.0835951 |
| SMYD3 | SET and MYND domain containing 3 | -0.0817036 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0681405 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0642454 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0637004 |
| METTL15 | methyltransferase like 15 | -0.0629546 |
| AK1 | adenylate kinase 1 | -0.0621114 |
| ENO1 | enolase 1, (alpha) | -0.0605856 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0594968 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0593635 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.0583349 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.058259 |
| RPL19 | ribosomal protein L19 | -0.0579921 |
| PEG10 | paternally expressed 10 | -0.0566909 |
| PRKCA | protein kinase C, alpha | -0.0564237 |
| HLA-B | major histocompatibility complex, class I, B | -0.056402 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0553935 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0548513 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.05442 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0530088 |
| RIGI | RNA sensor RIG-I | -0.0521566 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0504393 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0497963 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0497115 |
| INHBA | inhibin, beta A | -0.0488862 |
| NRG1 | neuregulin 1 | -0.0487807 |
| OGA | O-GlcNAcase | -0.04846 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0479841 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0474664 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0465101 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0461921 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0461386 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0459766 |
| WASF2 | WAS protein family, member 2 | -0.0442409 |
| AHR | aryl hydrocarbon receptor | -0.0438116 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0433274 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0427445 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0415659 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0413815 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0412853 |
| TPI1 | triosephosphate isomerase 1 | -0.0412023 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0409626 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0406524 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0397251 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0395379 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | -0.0390867 |
| GNAS | GNAS complex locus | -0.0378733 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0374757 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0372468 |
| ARCN1 | archain 1 | -0.0369141 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0366355 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0366078 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0365851 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0361081 |
| FRMD5 | FERM domain containing 5 | -0.0356947 |
| MSI2 | musashi RNA-binding protein 2 | -0.0353296 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0351562 |
| RAD51B | RAD51 paralog B | -0.0342282 |
| DENND5B | DENN/MADD domain containing 5B | -0.033942 |
| TXNRD1 | thioredoxin reductase 1 | -0.0336908 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0336518 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0335095 |
| RPS21 | ribosomal protein S21 | -0.0331167 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0327221 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0323539 |
| FOXJ3 | forkhead box J3 | -0.0320603 |
| MAP1B | microtubule-associated protein 1B | -0.0319457 |
| RNF216 | ring finger protein 216 | -0.0319117 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0318028 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0316611 |
| RANBP2 | RAN binding protein 2 | -0.03147 |
| JAK1 | Janus kinase 1 | -0.0311742 |
| RPL11 | ribosomal protein L11 | -0.0305457 |
| RPL34 | ribosomal protein L34 | -0.0304329 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.03035 |
| NEBL | nebulette | -0.0302473 |
| DTNA | dystrobrevin, alpha | -0.0301815 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0300157 |
| ACTN1 | actinin, alpha 1 | -0.0298443 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0297893 |
| SRP54 | signal recognition particle 54kDa | -0.0296886 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0294349 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0294349 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0292368 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0290756 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0290369 |
| RBM25 | RNA binding motif protein 25 | -0.0275155 |
