Ivabradine (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.144169
RPS3 ribosomal protein S3 0.0659184
RPL35A ribosomal protein L35a 0.052007
RPL37A ribosomal protein L37a 0.0509462
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.049453
VIM vimentin 0.0490029
RPS12 ribosomal protein S12 0.0489201
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0488828
RPS8 ribosomal protein S8 0.0442737
RPLP1 ribosomal protein, large, P1 0.0439882
POTEF POTE ankyrin domain family, member F 0.0401181
YBX1 Y box binding protein 1 0.0395418
RPL26 ribosomal protein L26 0.0372763
RPS27 ribosomal protein S27 0.0361036
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0328752
MT2A metallothionein 2A 0.0324675
RPL3 ribosomal protein L3 0.0314358
RPL37 ribosomal protein L37 0.0303705
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0302723
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0302416
TXNRD1 thioredoxin reductase 1 0.0293126
RPL31 ribosomal protein L31 0.0290144
FTL ferritin, light polypeptide 0.0273106
EIF1 eukaryotic translation initiation factor 1 0.0271787
CENPF centromere protein F, 350/400kDa 0.0264711
RPS19 ribosomal protein S19 0.0264062
MKI67 marker of proliferation Ki-67 0.0263252
GPX4 glutathione peroxidase 4 0.0257158
SET SET nuclear proto-oncogene 0.0255928
MYL12B myosin, light chain 12B, regulatory 0.0249274
ACTG1 actin gamma 1 0.0247386
RPLP2 ribosomal protein, large, P2 0.0243985
RPS17 ribosomal protein S17 0.0240564
RPS14 ribosomal protein S14 0.0238771
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0233771
TPM3 tropomyosin 3 0.0230603
RPL11 ribosomal protein L11 0.0228855
RPS6 ribosomal protein S6 0.022675
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0224374
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.022389
RPL36 ribosomal protein L36 0.0223254
RPL4 ribosomal protein L4 0.0217865
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0210063
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0209482
KTN1 kinectin 1 (kinesin receptor) 0.0202846
RAB6A RAB6A, member RAS oncogene family 0.0200618
RPL12 ribosomal protein L12 0.0197395
RPS10 ribosomal protein S10 0.0197266
RPS20 ribosomal protein S20 0.0192239
RPS7 ribosomal protein S7 0.0190101
HDGF hepatoma-derived growth factor 0.0185736
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0185562
RPS29 ribosomal protein S29 0.0184043
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0182417
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0179362
GATAD2B GATA zinc finger domain containing 2B 0.0179351
RTN4 reticulon 4 0.0179231
RPL9 ribosomal protein L9 0.0177197
IQGAP3 IQ motif containing GTPase activating protein 3 0.0176627
RPS2 ribosomal protein S2 0.0174644
TPR translocated promoter region, nuclear basket protein 0.0173485
ADAM17 ADAM metallopeptidase domain 17 0.0172254
PNN pinin, desmosome associated protein 0.0171548
RPL7 ribosomal protein L7 0.0171087
MSN moesin 0.0170201
KPNB1 karyopherin (importin) beta 1 0.0167628
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0167113
PAWR PRKC, apoptosis, WT1, regulator 0.0166227
RPL19 ribosomal protein L19 0.0166219
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0165788
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0165527
EIF4A1 eukaryotic translation initiation factor 4A1 0.0161864
HLTF helicase-like transcription factor 0.0161215
GSTP1 glutathione S-transferase pi 1 0.0160778
RACK1 receptor for activated C kinase 1 0.0159651
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.015744
NAP1L1 nucleosome assembly protein 1-like 1 0.0155158
RUSC2 RUN and SH3 domain containing 2 0.0155118
RPS21 ribosomal protein S21 0.0153809
RPL34 ribosomal protein L34 0.0153704
ANLN anillin, actin binding protein 0.0153607
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0152951
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0152664
RPL27 ribosomal protein L27 0.0152611
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.015254
ADAM9 ADAM metallopeptidase domain 9 0.0150505
SEC61G Sec61 gamma subunit 0.0149219
PTMS parathymosin 0.0148459
PFDN2 prefoldin subunit 2 0.0148407
PCBP2 poly(rC) binding protein 2 0.0148249
OGA O-GlcNAcase 0.0147145
PPME1 protein phosphatase methylesterase 1 0.0146816
PA2G4 proliferation-associated 2G4, 38kDa 0.0146764
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0144872
RPL5 ribosomal protein L5 0.0143094
RPL13A ribosomal protein L13a 0.0142502
CIP2A cellular inhibitor of PP2A 0.0142322
RPLP0 ribosomal protein, large, P0 0.0140124
ATP5F1E ATP synthase F1 subunit epsilon 0.0139858
FBL fibrillarin 0.013888

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.218768
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195616
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.155577
YBX3 Y box binding protein 3 -0.117677
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.113273
THSD4 thrombospondin, type I, domain containing 4 -0.106599
OSMR oncostatin M receptor -0.104081
PDE4D phosphodiesterase 4D, cAMP-specific -0.0946159
UBC ubiquitin C -0.0932644
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0839516
PDE10A phosphodiesterase 10A -0.0830315
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0755069
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0713664
DOCK5 dedicator of cytokinesis 5 -0.0697893
EML4 echinoderm microtubule associated protein like 4 -0.0689277
IGF1R insulin-like growth factor 1 receptor -0.0682897
AFF3 AF4/FMR2 family, member 3 -0.0678751
VCL vinculin -0.0674423
EGR1 early growth response 1 -0.0665083
GRAMD1B GRAM domain containing 1B -0.0658764
TAS2R14 taste receptor, type 2, member 14 -0.0643141
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0642323
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0639991
FMNL2 formin-like 2 -0.0633736
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0616905
HMGA2 high mobility group AT-hook 2 -0.0596079
TM4SF1 transmembrane 4 L six family member 1 -0.0588279
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0583542
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0579859
NF1 neurofibromin 1 -0.0574137
RIMS2 regulating synaptic membrane exocytosis 2 -0.0563755
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0555586
ZCCHC7 zinc finger, CCHC domain containing 7 -0.055514
PDLIM5 PDZ and LIM domain 5 -0.0553504
AEBP2 AE binding protein 2 -0.0548748
MCL1 myeloid cell leukemia 1 -0.0522555
NCOA7 nuclear receptor coactivator 7 -0.0505348
PRH1 proline-rich protein HaeIII subfamily 1 -0.0505312
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0488546
FNDC3B fibronectin type III domain containing 3B -0.0480957
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0459666
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0459432
ATXN1 ataxin 1 -0.0456388
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0450764
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.042929
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0429025
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0427402
SLC38A2 solute carrier family 38, member 2 -0.0426633
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0425254
TRIP12 thyroid hormone receptor interactor 12 -0.0424834
NABP1 nucleic acid binding protein 1 -0.0423015
TFPI2 tissue factor pathway inhibitor 2 -0.0419577
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0412272
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0407898
EGFR epidermal growth factor receptor -0.0406921
ATF6 activating transcription factor 6 -0.0402357
WNT2B wingless-type MMTV integration site family, member 2B -0.0398279
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0396957
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0391781
INTS6 integrator complex subunit 6 -0.0389421
H1-0 H1.0 linker histone -0.0389046
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0380415
FBXO11 F-box protein 11 -0.0380194
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.037987
ATP11A ATPase, class VI, type 11A -0.0379782
STC1 stanniocalcin 1 -0.037482
WWTR1 WW domain containing transcription regulator 1 -0.0370285
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0369868
ATG7 autophagy related 7 -0.0361758
RYR3 ryanodine receptor 3 -0.0360704
RAB7A RAB7A, member RAS oncogene family -0.0359253
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0359151
SVIL supervillin -0.0354279
RBM39 RNA binding motif protein 39 -0.0350119
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0349578
USP34 ubiquitin specific peptidase 34 -0.0349232
ZBTB20 zinc finger and BTB domain containing 20 -0.0347647
ELL2 elongation factor, RNA polymerase II, 2 -0.0345277
CANX calnexin -0.0341872
DENND5B DENN/MADD domain containing 5B -0.0337186
SPIDR scaffolding protein involved in DNA repair -0.0335146
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0327722
ZFAND3 zinc finger, AN1-type domain 3 -0.0327531
FUS FUS RNA binding protein -0.0326414
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0324618
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0320039
LARP4B La ribonucleoprotein domain family, member 4B -0.0319849
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0317051
RAD51B RAD51 paralog B -0.0315717
EXT1 exostosin glycosyltransferase 1 -0.0315581
CDK17 cyclin-dependent kinase 17 -0.0312652
MACF1 microtubule-actin crosslinking factor 1 -0.0310207
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0309327
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.030733
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0306839
PDIA3 protein disulfide isomerase family A, member 3 -0.0305728
HDAC8 histone deacetylase 8 -0.0303489
PRELID2 PRELI domain containing 2 -0.0296233
PUM1 pumilio RNA-binding family member 1 -0.0295133
LPP LIM domain containing preferred translocation partner in lipoma -0.0292057