| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | 0.166252 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.161292 |
| PTMA | prothymosin, alpha | 0.137267 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.107343 |
| ASPH | aspartate beta-hydroxylase | 0.0965875 |
| RPS3 | ribosomal protein S3 | 0.0911117 |
| ACTG1 | actin gamma 1 | 0.0843788 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.080211 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0786447 |
| LAMB3 | laminin, beta 3 | 0.071516 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0644829 |
| RPL4 | ribosomal protein L4 | 0.0636577 |
| RPL37A | ribosomal protein L37a | 0.0605761 |
| FN1 | fibronectin 1 | 0.0548926 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0543473 |
| RPL3 | ribosomal protein L3 | 0.0540133 |
| AHNAK | AHNAK nucleoprotein | 0.0524014 |
| RPS12 | ribosomal protein S12 | 0.0518228 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0514292 |
| CALR | calreticulin | 0.0514187 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0512095 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0506543 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0504505 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0495959 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0484389 |
| RACK1 | receptor for activated C kinase 1 | 0.0479009 |
| SET | SET nuclear proto-oncogene | 0.0476886 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0467665 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0467034 |
| TPM3 | tropomyosin 3 | 0.0466788 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0466041 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0454041 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0447131 |
| PLEC | plectin | 0.04449 |
| LAMC2 | laminin, gamma 2 | 0.0436304 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0420521 |
| RPL23 | ribosomal protein L23 | 0.0415274 |
| SDC4 | syndecan 4 | 0.0410122 |
| RPL37 | ribosomal protein L37 | 0.0407708 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.039834 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0380108 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0371296 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0359228 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0356105 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0349258 |
| ENO1 | enolase 1, (alpha) | 0.0348679 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0344884 |
| APP | amyloid beta (A4) precursor protein | 0.0344599 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0336585 |
| RPS27A | ribosomal protein S27a | 0.0335559 |
| PCBP2 | poly(rC) binding protein 2 | 0.033295 |
| YTHDC1 | YTH domain containing 1 | 0.0331615 |
| RPS17 | ribosomal protein S17 | 0.0330319 |
| RPS29 | ribosomal protein S29 | 0.0329135 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0326632 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0325449 |
| FAM13A | family with sequence similarity 13, member A | 0.0319929 |
| RPS8 | ribosomal protein S8 | 0.0317638 |
| RPL5 | ribosomal protein L5 | 0.0317471 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0315874 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0313338 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0312362 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0308868 |
| RBM39 | RNA binding motif protein 39 | 0.0307697 |
| NCKAP1 | NCK-associated protein 1 | 0.0302182 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.030164 |
| VEGFA | vascular endothelial growth factor A | 0.0300855 |
| RPL9 | ribosomal protein L9 | 0.0295819 |
| RPL14 | ribosomal protein L14 | 0.0291042 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0289182 |
| MCL1 | myeloid cell leukemia 1 | 0.0287609 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0287383 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0287251 |
| RPL27 | ribosomal protein L27 | 0.0286913 |
| RPL7 | ribosomal protein L7 | 0.0286469 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0285565 |
| HDGF | hepatoma-derived growth factor | 0.028425 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0283758 |
| GPX4 | glutathione peroxidase 4 | 0.0274292 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.0271581 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0265749 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0265576 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.026346 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0260806 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0260128 |
| DUSP10 | dual specificity phosphatase 10 | 0.0259967 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0257209 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0255956 |
| RBM25 | RNA binding motif protein 25 | 0.0254628 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0254251 |
| RBM33 | RNA binding motif protein 33 | 0.0252685 |
| RYK | receptor-like tyrosine kinase | 0.0252028 |
| GOLGA4 | golgin A4 | 0.0250298 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.024768 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0247385 |
| DIAPH1 | diaphanous-related formin 1 | 0.0247026 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0244709 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0243162 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.02378 |
| FLNB | filamin B, beta | 0.0236838 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.430197 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.180219 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.110847 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.105899 |
| HMGA1 | high mobility group AT-hook 1 | -0.0979931 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0909751 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0840904 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0749529 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0718357 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0574038 |
| UBC | ubiquitin C | -0.0526264 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0523974 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0500172 |
| CCND1 | cyclin D1 | -0.0498106 |
| CD2AP | CD2-associated protein | -0.0479577 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0474065 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0462074 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0446955 |
| NDRG1 | N-myc downstream regulated 1 | -0.0442378 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0438337 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0434049 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.042958 |
| MXD1 | MAX dimerization protein 1 | -0.0427376 |
| S100A10 | S100 calcium binding protein A10 | -0.0425999 |
| H1-0 | H1.0 linker histone | -0.0417811 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0414665 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0399739 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0397649 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0397286 |
| MT2A | metallothionein 2A | -0.0389739 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0388894 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0384198 |
| ARF1 | ADP-ribosylation factor 1 | -0.0383591 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0383563 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0378615 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0376433 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0375443 |
| S100A6 | S100 calcium binding protein A6 | -0.0373047 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0370627 |
| MYO1E | myosin IE | -0.0363968 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0359612 |
| RNF213 | ring finger protein 213 | -0.0354621 |
| CCNI | cyclin I | -0.035152 |
| TMEM263 | transmembrane protein 263 | -0.0349432 |
| RPL8 | ribosomal protein L8 | -0.0347687 |
| F11R | F11 receptor | -0.0337061 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0332133 |
| MAP1B | microtubule-associated protein 1B | -0.0325602 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0324645 |
| TMEM123 | transmembrane protein 123 | -0.0322499 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0311151 |
| OSMR | oncostatin M receptor | -0.0309668 |
| MX2 | MX dynamin-like GTPase 2 | -0.0309506 |
| TMSB10 | thymosin beta 10 | -0.030853 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0308155 |
| G0S2 | G0/G1 switch 2 | -0.0306475 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0301766 |
| VCL | vinculin | -0.0296158 |
| LOC112694756 | uncharaterized LOC112694756 | -0.029528 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0294848 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0293892 |
| KRT19 | keratin 19, type I | -0.0291623 |
| WASF2 | WAS protein family, member 2 | -0.0286621 |
| LDHA | lactate dehydrogenase A | -0.0285832 |
| GNAS | GNAS complex locus | -0.0282488 |
| FBXO32 | F-box protein 32 | -0.0280978 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0278876 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0278205 |
| TAPBP | TAP binding protein (tapasin) | -0.0276816 |
| STEAP4 | STEAP family member 4 | -0.02756 |
| CSTB | cystatin B (stefin B) | -0.0274341 |
| SP100 | SP100 nuclear antigen | -0.0273434 |
| CD44 | CD44 molecule (Indian blood group) | -0.0267673 |
| TUBA1B | tubulin, alpha 1b | -0.0264594 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0262699 |
| TPI1 | triosephosphate isomerase 1 | -0.026253 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0261752 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0258576 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0256445 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0256127 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.025558 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0253165 |
| NAV2 | neuron navigator 2 | -0.0252658 |
| SEPTIN11 | septin 11 | -0.0252354 |
| DSG2 | desmoglein 2 | -0.0251747 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0250596 |
| CTSD | cathepsin D | -0.0248226 |
| CLDN4 | claudin 4 | -0.0248013 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0247125 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0242338 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0241743 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0241367 |
| LMO7 | LIM domain 7 | -0.0239649 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0239362 |
| PALLD | palladin, cytoskeletal associated protein | -0.0237858 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.023598 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0235072 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0234694 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0234297 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0232478 |
