| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MCL1 | myeloid cell leukemia 1 | 0.154034 |
| EFNA5 | ephrin-A5 | 0.118213 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0714124 |
| PCBP2 | poly(rC) binding protein 2 | 0.0643377 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0624137 |
| RPL3 | ribosomal protein L3 | 0.0590816 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0587022 |
| GRAMD1B | GRAM domain containing 1B | 0.0580019 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0565527 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0500553 |
| ASPH | aspartate beta-hydroxylase | 0.0470956 |
| ENO1 | enolase 1, (alpha) | 0.0456613 |
| FLNB | filamin B, beta | 0.0453623 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0453241 |
| DST | dystonin | 0.0385896 |
| PTEN | phosphatase and tensin homolog | 0.0385842 |
| TPM3 | tropomyosin 3 | 0.0381548 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0356831 |
| RPS12 | ribosomal protein S12 | 0.0352354 |
| MYOF | myoferlin | 0.035209 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0327858 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0320748 |
| SET | SET nuclear proto-oncogene | 0.0319029 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0315679 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0310571 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0309147 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.0305592 |
| DNER | delta/notch-like EGF repeat containing | 0.0303089 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0298807 |
| AHNAK | AHNAK nucleoprotein | 0.0297898 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0290215 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0289394 |
| PRELID2 | PRELI domain containing 2 | 0.0288448 |
| POTEF | POTE ankyrin domain family, member F | 0.0285437 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0285208 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0267379 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0266531 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.026516 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0260331 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0251713 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0243878 |
| RPL4 | ribosomal protein L4 | 0.0233843 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.023013 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0227706 |
| RPS3 | ribosomal protein S3 | 0.0224475 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.022439 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0223763 |
| PCBP3 | poly(rC) binding protein 3 | 0.0220235 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0220217 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0218714 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.021743 |
| PM20D1 | peptidase M20 domain containing 1 | 0.021509 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0213471 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0213306 |
| USP34 | ubiquitin specific peptidase 34 | 0.0212286 |
| NHSL1 | NHS-like 1 | 0.0210264 |
| PTMA | prothymosin, alpha | 0.0206794 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0204759 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0202493 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.020098 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0200568 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0197554 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0193618 |
| BDNF | brain-derived neurotrophic factor | 0.0191471 |
| MSN | moesin | 0.0189624 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0189089 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0187677 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0187308 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.018646 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0184669 |
| RPL37A | ribosomal protein L37a | 0.0184129 |
| RAD51B | RAD51 paralog B | 0.0184117 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0182262 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0178182 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0177319 |
| HDAC4 | histone deacetylase 4 | 0.017628 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0175577 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0172344 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0171851 |
| FAM13A | family with sequence similarity 13, member A | 0.0169929 |
| VMP1 | vacuole membrane protein 1 | 0.0168658 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0166861 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0165785 |
| MDM4 | MDM4, p53 regulator | 0.0165755 |
| RPS7 | ribosomal protein S7 | 0.0165443 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0164938 |
| FMNL2 | formin-like 2 | 0.0164302 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0158002 |
| ANKRD36 | ankyrin repeat domain 36 | 0.015438 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0154104 |
| CENPF | centromere protein F, 350/400kDa | 0.0153686 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0153635 |
| SMC1A | structural maintenance of chromosomes 1A | 0.015349 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0151711 |
| MFF | mitochondrial fission factor | 0.0150179 |
| NIBAN2 | niban apoptosis regulator 2 | 0.014893 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0147597 |
| FAM219A | family with sequence similarity 219, member A | 0.0146707 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0146419 |
| PYGL | phosphorylase, glycogen, liver | 0.0146147 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.326605 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.214747 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.201717 |
| FN1 | fibronectin 1 | -0.182486 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.127719 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.113738 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.103166 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0865646 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.084959 |
| RPS6 | ribosomal protein S6 | -0.0772072 |
| TMSB10 | thymosin beta 10 | -0.0749648 |
| RPS24 | ribosomal protein S24 | -0.0744417 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0736381 |
| TXNRD1 | thioredoxin reductase 1 | -0.06158 |
| FTL | ferritin, light polypeptide | -0.0569705 |
| RPL35A | ribosomal protein L35a | -0.0560226 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0536405 |
| RPLP0 | ribosomal protein, large, P0 | -0.0520839 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0494573 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0488218 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0479256 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0465644 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0462727 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0456631 |
| RPL34 | ribosomal protein L34 | -0.0444207 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0438967 |
| RPLP1 | ribosomal protein, large, P1 | -0.0437163 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0431114 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0426034 |
| GNAS | GNAS complex locus | -0.04258 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0420063 |
| RTN4 | reticulon 4 | -0.0415912 |
| RPL12 | ribosomal protein L12 | -0.0415128 |
| S100A10 | S100 calcium binding protein A10 | -0.0414104 |
| HLA-B | major histocompatibility complex, class I, B | -0.041241 |
| SPAG9 | sperm associated antigen 9 | -0.0409422 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0402942 |
| CANX | calnexin | -0.0389569 |
| VIM | vimentin | -0.0385912 |
| ARF1 | ADP-ribosylation factor 1 | -0.0384891 |
| RPL38 | ribosomal protein L38 | -0.0374994 |
| UBC | ubiquitin C | -0.0372986 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0372607 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0371429 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0361194 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0358724 |
| RPS21 | ribosomal protein S21 | -0.0357843 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0348127 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0318216 |
| RPS23 | ribosomal protein S23 | -0.031819 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0318006 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0314206 |
| MAP1B | microtubule-associated protein 1B | -0.0312278 |
| LDHA | lactate dehydrogenase A | -0.0309922 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0309008 |
| RGS2 | regulator of G-protein signaling 2 | -0.0307485 |
| SRGN | serglycin | -0.0306587 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0298561 |
| CDH13 | cadherin 13 | -0.0296055 |
| PGK1 | phosphoglycerate kinase 1 | -0.02928 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0292781 |
| FUS | FUS RNA binding protein | -0.0292363 |
| STC1 | stanniocalcin 1 | -0.0286012 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0282894 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0282427 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0281967 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0280497 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0279933 |
| RPS16 | ribosomal protein S16 | -0.0276949 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0276565 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0275423 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0273712 |
| RPL19 | ribosomal protein L19 | -0.0272301 |
| RPL36A | ribosomal protein L36a | -0.0271453 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0268764 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0261297 |
| JMJD1C | jumonji domain containing 1C | -0.0261205 |
| MORF4L2 | mortality factor 4 like 2 | -0.0260687 |
| RPS15 | ribosomal protein S15 | -0.0257179 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0255166 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0252743 |
| RPL8 | ribosomal protein L8 | -0.0252272 |
| S100A6 | S100 calcium binding protein A6 | -0.0249464 |
| VCL | vinculin | -0.024888 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0248147 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0246938 |
| RPL32 | ribosomal protein L32 | -0.0246821 |
| IER3 | immediate early response 3 | -0.0246482 |
| USP3 | ubiquitin specific peptidase 3 | -0.0240821 |
| HMGB1 | high mobility group box 1 | -0.0239461 |
| RPS25 | ribosomal protein S25 | -0.0239438 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0235972 |
| SMYD3 | SET and MYND domain containing 3 | -0.0232991 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0232911 |
| RPL13A | ribosomal protein L13a | -0.0230475 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0229437 |
| RPL35 | ribosomal protein L35 | -0.02283 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.022777 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0226611 |
| YBX3 | Y box binding protein 3 | -0.0219666 |
