Ivabradine (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

107 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.346585
THSD4 thrombospondin, type I, domain containing 4 0.256617
EPS8 epidermal growth factor receptor pathway substrate 8 0.203225
WAC WW domain containing adaptor with coiled-coil 0.181995
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.172637
ENO1 enolase 1, (alpha) 0.13039
ZNF292 zinc finger protein 292 0.126355
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.12378
PTMA prothymosin, alpha 0.114671
GOLGA4 golgin A4 0.093897
RAB7A RAB7A, member RAS oncogene family 0.0931484
SBF2 SET binding factor 2 0.0914356
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0882246
ANXA2 annexin A2 0.0856745
FTH1 ferritin, heavy polypeptide 1 0.0848085
AKAP12 A kinase (PRKA) anchor protein 12 0.0847275
KMT2C lysine (K)-specific methyltransferase 2C 0.0750896
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0744571
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0709169
KMT2E lysine (K)-specific methyltransferase 2E 0.0662014
SMYD3 SET and MYND domain containing 3 0.0641687
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0637816
RPS6 ribosomal protein S6 0.0562502
VIM vimentin 0.0555157
ACTG1 actin gamma 1 0.0524946
FNDC3B fibronectin type III domain containing 3B 0.045371
GNPDA1 glucosamine-6-phosphate deaminase 1 0.044968
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0409719
ASPH aspartate beta-hydroxylase 0.0377212
RAB10 RAB10, member RAS oncogene family 0.0371574
LPP LIM domain containing preferred translocation partner in lipoma 0.0353063
TMSB10 thymosin beta 10 0.0332605
ANKHD1 ankyrin repeat and KH domain containing 1 0.0265854
SPAG9 sperm associated antigen 9 0.0264322
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0258825
RUNX1 runt-related transcription factor 1 0.0246294
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0210582
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0201143
ITGA6 integrin, alpha 6 0.016045
GOLGB1 golgin B1 0.015879
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0146514
NAMPT nicotinamide phosphoribosyltransferase 0.0146108
SLTM SAFB-like, transcription modulator 0.0143412
RPS24 ribosomal protein S24 0.0128809
POTEF POTE ankyrin domain family, member F 0.01095
MED13L mediator complex subunit 13-like 0.00735296
EXT1 exostosin glycosyltransferase 1 0.00611696
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.00559369
PARD3 par-3 family cell polarity regulator 7.06582E-4

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.164036
CADM2 cell adhesion molecule 2 -0.136601
CXCL8 chemokine (C-X-C motif) ligand 8 -0.133756
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.112525
TXNRD1 thioredoxin reductase 1 -0.105287
ERRFI1 ERBB receptor feedback inhibitor 1 -0.10177
HMGA2 high mobility group AT-hook 2 -0.0986663
DST dystonin -0.0984202
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0955813
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0944916
CD44 CD44 molecule (Indian blood group) -0.0944334
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0939858
NALF1 NALCN channel auxiliary factor 1 -0.0845291
PKM pyruvate kinase, muscle -0.0835914
ZBTB20 zinc finger and BTB domain containing 20 -0.0835638
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0813584
VCL vinculin -0.0812371
CANX calnexin -0.0727874
PRKCA protein kinase C, alpha -0.0710397
ATXN1 ataxin 1 -0.0686411
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0664669
ANKRD17 ankyrin repeat domain 17 -0.0654567
KTN1 kinectin 1 (kinesin receptor) -0.0629822
TENM3 teneurin transmembrane protein 3 -0.0580821
PEG10 paternally expressed 10 -0.0567803
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0521673
ATP11A ATPase, class VI, type 11A -0.05211
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.050709
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0473586
FN1 fibronectin 1 -0.0471857
PDE10A phosphodiesterase 10A -0.0450891
NDRG1 N-myc downstream regulated 1 -0.0433295
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0398722
RPL35A ribosomal protein L35a -0.039635
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0396257
KYNU kynureninase -0.0392133
RORA RAR-related orphan receptor A -0.0375641
JMJD1C jumonji domain containing 1C -0.0374358
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0369209
PSD3 pleckstrin and Sec7 domain containing 3 -0.0368345
FMNL2 formin-like 2 -0.0357132
PDE4D phosphodiesterase 4D, cAMP-specific -0.03452
ARRDC3 arrestin domain containing 3 -0.0331104
WSB1 WD repeat and SOCS box containing 1 -0.0279982
EFNA5 ephrin-A5 -0.0266207
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0245037
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0226692
SETD5 SET domain containing 5 -0.0220325
EGFR epidermal growth factor receptor -0.021954
ANKRD12 ankyrin repeat domain 12 -0.0210106
TPT1 tumor protein, translationally-controlled 1 -0.0192321
IGF2 insulin-like growth factor 2 -0.0189846
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.018392
DTNA dystrobrevin, alpha -0.0178888
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0177399
PTK2 protein tyrosine kinase 2 -0.0152615
MT2A metallothionein 2A -0.0117767
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.00754076