| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ivabradine (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A2 | collagen, type V, alpha 2 | 0.138932 |
| PTMA | prothymosin, alpha | 0.112371 |
| COL3A1 | collagen, type III, alpha 1 | 0.110382 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.106688 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.100302 |
| COL1A2 | collagen, type I, alpha 2 | 0.087658 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.082902 |
| FOXG1 | forkhead box G1 | 0.0804009 |
| ZNF292 | zinc finger protein 292 | 0.0762266 |
| THBS1 | thrombospondin 1 | 0.0755376 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0729786 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.069548 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0646973 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0595472 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0561641 |
| SET | SET nuclear proto-oncogene | 0.0535578 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0517729 |
| PLPP1 | phospholipid phosphatase 1 | 0.0515112 |
| CALR | calreticulin | 0.0513856 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0493693 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0492395 |
| ACTG1 | actin gamma 1 | 0.0489167 |
| CANX | calnexin | 0.0475188 |
| MKI67 | marker of proliferation Ki-67 | 0.0456139 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0450357 |
| WDR43 | WD repeat domain 43 | 0.044968 |
| ITGAV | integrin, alpha V | 0.0439922 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0435298 |
| CADM2 | cell adhesion molecule 2 | 0.0425132 |
| TMSB10 | thymosin beta 10 | 0.0419382 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0416599 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0414186 |
| EVI5 | ecotropic viral integration site 5 | 0.041338 |
| MB21D2 | Mab-21 domain containing 2 | 0.0410164 |
| SRP54 | signal recognition particle 54kDa | 0.0408224 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0402079 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0389001 |
| RAI1 | retinoic acid induced 1 | 0.0384938 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0384216 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.0384071 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0383396 |
| SPAG9 | sperm associated antigen 9 | 0.0381984 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0374075 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0373683 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0371491 |
| DMD | dystrophin | 0.0368176 |
| RIGI | RNA sensor RIG-I | 0.0363516 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0361255 |
| HMGB2 | high mobility group box 2 | 0.0360346 |
| APP | amyloid beta (A4) precursor protein | 0.0359103 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0356535 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0355552 |
| MEF2A | myocyte enhancer factor 2A | 0.0355387 |
| NPAS3 | neuronal PAS domain protein 3 | 0.0355077 |
| PSMD8 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 | 0.0351099 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.0346959 |
| YAP1 | Yes-associated protein 1 | 0.0344502 |
| AHNAK | AHNAK nucleoprotein | 0.0342115 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0341893 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0341542 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0340683 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0339436 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0338365 |
| PNN | pinin, desmosome associated protein | 0.0333487 |
| SMYD3 | SET and MYND domain containing 3 | 0.0332366 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0316791 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.031666 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0314431 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0310234 |
| H2AZ2 | H2A.Z variant histone 2 | 0.0309329 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0305832 |
| RTF1 | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) | 0.0304557 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | 0.0304089 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0302846 |
| GAP43 | growth associated protein 43 | 0.0300255 |
| MATR3 | matrin 3 | 0.0296871 |
| CXADR | coxsackie virus and adenovirus receptor | 0.0293832 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0293642 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0290138 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0288752 |
| PGPEP1L | pyroglutamyl-peptidase I-like | 0.0287809 |
| SUN1 | Sad1 and UNC84 domain containing 1 | 0.0287502 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0285863 |
| TPR | translocated promoter region, nuclear basket protein | 0.0285567 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0284299 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0284058 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.028352 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0281495 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0281232 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0280761 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.028068 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0280226 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0276556 |
| TMSB4X | thymosin beta 4, X-linked | 0.0276292 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0275186 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.0273332 |
| RPS7 | ribosomal protein S7 | 0.0272397 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0271795 |
| POTEF | POTE ankyrin domain family, member F | 0.0271354 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0269615 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.092884 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0869303 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0808395 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0769744 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0768667 |
| RPS6 | ribosomal protein S6 | -0.0758592 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0745014 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0684526 |
| MED13L | mediator complex subunit 13-like | -0.0624237 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0620959 |
| MAP4 | microtubule-associated protein 4 | -0.0613688 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0570078 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0539751 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0526573 |
| SETD5 | SET domain containing 5 | -0.0524833 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0518049 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.051696 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0498047 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0474847 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0457491 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0446355 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0444642 |
| NTM | neurotrimin | -0.0442848 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0441175 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0436426 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0434724 |
| OGA | O-GlcNAcase | -0.0433652 |
| PFN1 | profilin 1 | -0.043155 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0424406 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0417956 |
| TUBA1B | tubulin, alpha 1b | -0.0399318 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0398306 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.039321 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0390209 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0384506 |
| JMJD1C | jumonji domain containing 1C | -0.0368222 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0367572 |
| NFIB | nuclear factor I/B | -0.0365308 |
| SKIL | SKI-like proto-oncogene | -0.0363529 |
| CLIC4 | chloride intracellular channel 4 | -0.0363223 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0361159 |
| EMP1 | epithelial membrane protein 1 | -0.0358144 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0357049 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0353859 |
| USP34 | ubiquitin specific peptidase 34 | -0.0347889 |
| NF1 | neurofibromin 1 | -0.0346738 |
| EP300 | E1A binding protein p300 | -0.034474 |
| ATXN1 | ataxin 1 | -0.0344099 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0344049 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.033984 |
| TOX | thymocyte selection-associated high mobility group box | -0.0337675 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0337143 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0335271 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0331041 |
| UBN2 | ubinuclein 2 | -0.0325936 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0317112 |
| RPL23 | ribosomal protein L23 | -0.0316846 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0314034 |
| RNF216 | ring finger protein 216 | -0.0313001 |
| SGO2 | shugoshin 2 | -0.0312473 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0311255 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0310996 |
| RPL35A | ribosomal protein L35a | -0.0310418 |
| USP24 | ubiquitin specific peptidase 24 | -0.0309147 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0308948 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0306931 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0303197 |
| HMGA1 | high mobility group AT-hook 1 | -0.0301571 |
| RSF1 | remodeling and spacing factor 1 | -0.0300412 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0300149 |
| SHROOM3 | shroom family member 3 | -0.0299771 |
| MT2A | metallothionein 2A | -0.0298216 |
| RPS23 | ribosomal protein S23 | -0.0293437 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0292469 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0292267 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0290511 |
| SVIL | supervillin | -0.028969 |
| FTL | ferritin, light polypeptide | -0.0289543 |
| WASF2 | WAS protein family, member 2 | -0.0289421 |
| RTN4 | reticulon 4 | -0.0288276 |
| RCOR1 | REST corepressor 1 | -0.0286614 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0286013 |
| RAB30 | RAB30, member RAS oncogene family | -0.0284459 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0284192 |
| RRP1B | ribosomal RNA processing 1B | -0.0283406 |
| RPL34 | ribosomal protein L34 | -0.028012 |
| MYO10 | myosin X | -0.0278852 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0277461 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0276534 |
| R3HDM1 | R3H domain containing 1 | -0.0276088 |
| FN1 | fibronectin 1 | -0.0272994 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | -0.0272806 |
| CENPF | centromere protein F, 350/400kDa | -0.0267187 |
| MAP1B | microtubule-associated protein 1B | -0.0265035 |
| TPX2 | TPX2, microtubule-associated | -0.0264904 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0263575 |
| DSTN | destrin (actin depolymerizing factor) | -0.0263408 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0262389 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0261832 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0258814 |
