Ivabradine (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.0431945
ERRFI1 ERBB receptor feedback inhibitor 1 0.0393768
ARHGAP29 Rho GTPase activating protein 29 0.0360182
TSC22D2 TSC22 domain family, member 2 0.0342999
NRIP1 nuclear receptor interacting protein 1 0.0314666
FAM3C family with sequence similarity 3, member C 0.0310732
MYO6 myosin VI 0.0297347
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0283662
OGA O-GlcNAcase 0.0281699
GOLGA4 golgin A4 0.0260613
ANLN anillin, actin binding protein 0.0223213
UBA6 ubiquitin-like modifier activating enzyme 6 0.0220939
TMF1 TATA element modulatory factor 1 0.0211446
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0201304
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0197879
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0194705
LAMB3 laminin, beta 3 0.0193639
RPL3 ribosomal protein L3 0.0187941
AKAP9 A kinase (PRKA) anchor protein 9 0.0187446
RB1CC1 RB1-inducible coiled-coil 1 0.0180221
EIF4B eukaryotic translation initiation factor 4B 0.0175091
PCBP2 poly(rC) binding protein 2 0.0173301
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0162607
TRA2A transformer 2 alpha homolog (Drosophila) 0.0160879
FAM13A family with sequence similarity 13, member A 0.0159441
KDM6A lysine (K)-specific demethylase 6A 0.0153858
CAPRIN2 caprin family member 2 0.0151746
DDIT4 DNA-damage-inducible transcript 4 0.0151262
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0149313
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0149005
MATR3 matrin 3 0.0143743
ARRDC3 arrestin domain containing 3 0.0142348
COLEC11 collectin sub-family member 11 0.0141786
XPO1 exportin 1 0.0140943
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0140781
RNF145 ring finger protein 145 0.01397
BHLHE40 basic helix-loop-helix family, member e40 0.0139664
MYH9 myosin, heavy chain 9, non-muscle 0.0137261
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0137074
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0137042
PDIA6 protein disulfide isomerase family A, member 6 0.0135367
FRMD6 FERM domain containing 6 0.012998
SKAP2 src kinase associated phosphoprotein 2 0.0129824
SEC23A Sec23 homolog A (S. cerevisiae) 0.0129095
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0127789
SAMD4A sterile alpha motif domain containing 4A 0.0127288
ECT2 epithelial cell transforming 2 0.0126393
RNF149 ring finger protein 149 0.0124665
USP9X ubiquitin specific peptidase 9, X-linked 0.0123726
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0122747
CKAP5 cytoskeleton associated protein 5 0.0122377
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0121562
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0120049
AFDN afadin, adherens junction formation factor 0.0119922
ELL2 elongation factor, RNA polymerase II, 2 0.0115735
PDS5B PDS5 cohesin associated factor B 0.0114895
COPG1 coatomer protein complex, subunit gamma 1 0.0114809
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0113979
TUFT1 tuftelin 1 0.0113603
ATP13A3 ATPase type 13A3 0.0111837
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.01117
VEGFA vascular endothelial growth factor A 0.0111562
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.0110471
ZNF292 zinc finger protein 292 0.0109994
RALB v-ral simian leukemia viral oncogene homolog B 0.0109638
NPTN neuroplastin 0.0108441
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0107541
SRSF11 serine/arginine-rich splicing factor 11 0.0106701
PCM1 pericentriolar material 1 0.0106085
RBM26 RNA binding motif protein 26 0.0105451
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0104734
RPS7 ribosomal protein S7 0.0104333
YTHDC1 YTH domain containing 1 0.0102721
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0102293
PPME1 protein phosphatase methylesterase 1 0.0102134
PIAS2 protein inhibitor of activated STAT, 2 0.0101214
SRP54 signal recognition particle 54kDa 0.0100931
LRRC1 leucine rich repeat containing 1 0.0100857
RYK receptor-like tyrosine kinase 0.0100828
CUL3 cullin 3 0.00997703
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0099554
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0099233
CCNL1 cyclin L1 0.00991055
KIAA1328 KIAA1328 0.00988219
MIDEAS mitotic deacetylase associated SANT domain protein 0.00988002
TMEM245 transmembrane protein 245 0.00982962
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00978366
AZIN1 antizyme inhibitor 1 0.00975879
CDC27 cell division cycle 27 0.00971236
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.00968647
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.00967462
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.00962322
PNN pinin, desmosome associated protein 0.00944931
TFRC transferrin receptor 0.00938939
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0093741
NUMA1 nuclear mitotic apparatus protein 1 0.00937303
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.00935048
RYBP RING1 and YY1 binding protein 0.00932908
WDR26 WD repeat domain 26 0.00932546
CCNY cyclin Y 0.00930822

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.361658
TPT1 tumor protein, translationally-controlled 1 -0.145896
HMGA1 high mobility group AT-hook 1 -0.104365
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0978943
KRT19 keratin 19, type I -0.0937401
MUC4 mucin 4, cell surface associated -0.0885798
TMSB10 thymosin beta 10 -0.0880423
FN1 fibronectin 1 -0.087461
EMP1 epithelial membrane protein 1 -0.0854073
HLA-B major histocompatibility complex, class I, B -0.0830475
RPS6 ribosomal protein S6 -0.0824303
LMO7 LIM domain 7 -0.0807756
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0802098
ACTG1 actin gamma 1 -0.0773751
LAMA4 laminin, alpha 4 -0.0761889
RNF213 ring finger protein 213 -0.0742371
DSG2 desmoglein 2 -0.0694425
F3 coagulation factor III (thromboplastin, tissue factor) -0.0681522
B2M beta-2-microglobulin -0.0659337
UBC ubiquitin C -0.0644143
ZBTB20 zinc finger and BTB domain containing 20 -0.0612714
RPL35A ribosomal protein L35a -0.0597748
TM4SF1 transmembrane 4 L six family member 1 -0.0594547
CD44 CD44 molecule (Indian blood group) -0.0583604
KRT7 keratin 7, type II -0.0580164
MYO1E myosin IE -0.0565737
PLSCR1 phospholipid scramblase 1 -0.0559613
SVIL supervillin -0.0558744
TMSB4X thymosin beta 4, X-linked -0.0548398
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0547394
CD2AP CD2-associated protein -0.0544689
ANXA2 annexin A2 -0.0543187
EEF1G eukaryotic translation elongation factor 1 gamma -0.0542842
LY6E lymphocyte antigen 6 complex, locus E -0.0541831
MUC16 mucin 16, cell surface associated -0.053942
OSMR oncostatin M receptor -0.0533889
IFI27 interferon, alpha-inducible protein 27 -0.0532527
MT2A metallothionein 2A -0.0514472
RPS13 ribosomal protein S13 -0.0512695
RPL8 ribosomal protein L8 -0.0508228
RPLP1 ribosomal protein, large, P1 -0.0492243
RPL19 ribosomal protein L19 -0.0490253
LDHA lactate dehydrogenase A -0.0490227
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0484774
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0478758
LOC112694756 uncharaterized LOC112694756 -0.046663
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.046354
TPM4 tropomyosin 4 -0.0459071
IGFBP3 insulin-like growth factor binding protein 3 -0.0459071
FTH1 ferritin, heavy polypeptide 1 -0.0445842
HLA-A major histocompatibility complex, class I, A -0.0445462
RACK1 receptor for activated C kinase 1 -0.0442622
RPS21 ribosomal protein S21 -0.0441469
HLA-E major histocompatibility complex, class I, E -0.0438334
MX2 MX dynamin-like GTPase 2 -0.0437894
S100A6 S100 calcium binding protein A6 -0.0436889
RPS24 ribosomal protein S24 -0.0434998
RPL23 ribosomal protein L23 -0.0429548
KRT18 keratin 18, type I -0.042808
RPS15 ribosomal protein S15 -0.0426089
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0421025
RIGI RNA sensor RIG-I -0.0415141
RPL34 ribosomal protein L34 -0.0406657
RPS19 ribosomal protein S19 -0.0400358
H1-0 H1.0 linker histone -0.0394159
MAML2 mastermind-like 2 (Drosophila) -0.0393111
RPS29 ribosomal protein S29 -0.0391163
RPL28 ribosomal protein L28 -0.0390402
RPS8 ribosomal protein S8 -0.0387659
PGK1 phosphoglycerate kinase 1 -0.0387079
RPS27A ribosomal protein S27a -0.038376
SH3KBP1 SH3-domain kinase binding protein 1 -0.0383282
PLAUR plasminogen activator, urokinase receptor -0.0383077
LPP LIM domain containing preferred translocation partner in lipoma -0.0381283
MX1 MX dynamin-like GTPase 1 -0.0379946
SOX4 SRY (sex determining region Y)-box 4 -0.0370833
EGR1 early growth response 1 -0.0370405
RPS25 ribosomal protein S25 -0.0368787
EFNA5 ephrin-A5 -0.0363616
KRT8 keratin 8, type II -0.0363127
RPL12 ribosomal protein L12 -0.0361054
RPS23 ribosomal protein S23 -0.035707
ETV6 ets variant 6 -0.0356493
TPI1 triosephosphate isomerase 1 -0.0353798
RAB7A RAB7A, member RAS oncogene family -0.0352315
LAMC2 laminin, gamma 2 -0.0350917
PKM pyruvate kinase, muscle -0.0345189
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0344164
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0342136
HLA-C major histocompatibility complex, class I, C -0.0337278
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0334705
RPS5 ribosomal protein S5 -0.0333419
PATJ PATJ crumbs cell polarity complex component -0.0329771
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0329622
CCND1 cyclin D1 -0.0327396
LOC102724023 ES1 protein homolog, mitochondrial -0.0326312
RPL37 ribosomal protein L37 -0.0324615
EIF1 eukaryotic translation initiation factor 1 -0.031528
TJP1 tight junction protein 1 -0.0311871
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0310938