| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in RKO cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | 0.142541 |
| LAMB3 | laminin, beta 3 | 0.118509 |
| ENO1 | enolase 1, (alpha) | 0.0834062 |
| RPL4 | ribosomal protein L4 | 0.0776019 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0692202 |
| MCL1 | myeloid cell leukemia 1 | 0.0666757 |
| SET | SET nuclear proto-oncogene | 0.0660161 |
| AHNAK | AHNAK nucleoprotein | 0.0655466 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0635461 |
| RPS12 | ribosomal protein S12 | 0.0623671 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0601995 |
| RPL3 | ribosomal protein L3 | 0.0590555 |
| RPS3 | ribosomal protein S3 | 0.0571333 |
| PTMA | prothymosin, alpha | 0.0533715 |
| PGK1 | phosphoglycerate kinase 1 | 0.0515498 |
| RPL37A | ribosomal protein L37a | 0.0486495 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0485971 |
| RPS27A | ribosomal protein S27a | 0.0446996 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0439711 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0432086 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0422528 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0421287 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0421202 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0419113 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0376987 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0372344 |
| OGA | O-GlcNAcase | 0.0371644 |
| WDR26 | WD repeat domain 26 | 0.0362256 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0360322 |
| TXNRD1 | thioredoxin reductase 1 | 0.0356692 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0354647 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0349238 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0347304 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0336982 |
| USP34 | ubiquitin specific peptidase 34 | 0.0330472 |
| STK4 | serine/threonine kinase 4 | 0.0327529 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0323882 |
| PFKP | phosphofructokinase, platelet | 0.0323108 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0315945 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0311197 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0308419 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.030821 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0305283 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.029613 |
| PRELID2 | PRELI domain containing 2 | 0.0290668 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0286808 |
| RPL7 | ribosomal protein L7 | 0.0281957 |
| CORO1C | coronin, actin binding protein, 1C | 0.0280004 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0271336 |
| RPL26 | ribosomal protein L26 | 0.0270597 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0269246 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0266099 |
| AFDN | afadin, adherens junction formation factor | 0.0264802 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0263044 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0262791 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0261856 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0261462 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0258232 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0256239 |
| RPS2 | ribosomal protein S2 | 0.0256181 |
| GPR107 | G protein-coupled receptor 107 | 0.0255062 |
| FNBP4 | formin binding protein 4 | 0.0254301 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0253164 |
| NCKAP1 | NCK-associated protein 1 | 0.0252939 |
| ATP13A3 | ATPase type 13A3 | 0.0252526 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0252431 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.0251713 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0251584 |
| GOLM1 | golgi membrane protein 1 | 0.0251222 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0246624 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0246147 |
| WDR33 | WD repeat domain 33 | 0.0245256 |
| YEATS2 | YEATS domain containing 2 | 0.0240497 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0238348 |
| URI1 | URI1, prefoldin-like chaperone | 0.0235355 |
| APP | amyloid beta (A4) precursor protein | 0.0232143 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0230321 |
| TUT7 | terminal uridylyl transferase 7 | 0.0229823 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0228501 |
| ABI1 | abl-interactor 1 | 0.0227739 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0226978 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0226824 |
| ACTN1 | actinin, alpha 1 | 0.0226079 |
| CEP350 | centrosomal protein 350kDa | 0.0224505 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0224121 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0222746 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0222584 |
| ZNF106 | zinc finger protein 106 | 0.0222064 |
| FLNA | filamin A, alpha | 0.0221571 |
| KLC1 | kinesin light chain 1 | 0.0221344 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0221091 |
| NGLY1 | N-glycanase 1 | 0.022094 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0220147 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0220142 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0219589 |
| FMNL2 | formin-like 2 | 0.0217834 |
| RPS17 | ribosomal protein S17 | 0.0217209 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.021687 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0216803 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0216203 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.137212 |
| FRMD6 | FERM domain containing 6 | -0.134908 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.120361 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.119914 |
| RAB7A | RAB7A, member RAS oncogene family | -0.101469 |
| NABP1 | nucleic acid binding protein 1 | -0.0999579 |
| RPS6 | ribosomal protein S6 | -0.0985925 |
| ZNF438 | zinc finger protein 438 | -0.0935373 |
| JMJD1C | jumonji domain containing 1C | -0.0927498 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0891152 |
| HMGA1 | high mobility group AT-hook 1 | -0.0780975 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0770281 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0754566 |
| NAV3 | neuron navigator 3 | -0.0752167 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.074483 |
| EGR1 | early growth response 1 | -0.0674028 |
| RPL8 | ribosomal protein L8 | -0.0651005 |
| FTL | ferritin, light polypeptide | -0.0612647 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0579597 |
| MT2A | metallothionein 2A | -0.0573888 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0573406 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0542609 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0539162 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0531411 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0527444 |
| PFN1 | profilin 1 | -0.0515678 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0506757 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0500439 |
| PARD3 | par-3 family cell polarity regulator | -0.0491147 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0487609 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0465448 |
| INTS6 | integrator complex subunit 6 | -0.045623 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0453646 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0450124 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.044791 |
| RPL35A | ribosomal protein L35a | -0.0440061 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0433197 |
| SP100 | SP100 nuclear antigen | -0.0431605 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.0429558 |
| HMGA2 | high mobility group AT-hook 2 | -0.0428317 |
| FNIP1 | folliculin interacting protein 1 | -0.0426086 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.042242 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0421687 |
| BNC2 | basonuclin 2 | -0.0418142 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0411892 |
| SETD5 | SET domain containing 5 | -0.039469 |
| ERBIN | erbb2 interacting protein | -0.0391362 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0377839 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0372816 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.037118 |
| CALD1 | caldesmon 1 | -0.0369933 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0368402 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0362286 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0360721 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0358669 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0349807 |
| RAB3IP | RAB3A interacting protein | -0.0349272 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0339058 |
| TMEM87A | transmembrane protein 87A | -0.0339048 |
| STC1 | stanniocalcin 1 | -0.0325503 |
| POTEF | POTE ankyrin domain family, member F | -0.032218 |
| CCNL1 | cyclin L1 | -0.0319908 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0317643 |
| OLA1 | Obg-like ATPase 1 | -0.0315297 |
| TMSB10 | thymosin beta 10 | -0.031469 |
| BBX | bobby sox homolog (Drosophila) | -0.0311432 |
| RTN4 | reticulon 4 | -0.0308754 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0306737 |
| SDCBP | syndecan binding protein (syntenin) | -0.0306303 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0300545 |
| RPLP0 | ribosomal protein, large, P0 | -0.0300049 |
| RHEB | Ras homolog enriched in brain | -0.0298581 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.0297233 |
| RUNX1 | runt-related transcription factor 1 | -0.0296606 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0295105 |
| VMP1 | vacuole membrane protein 1 | -0.0293584 |
| GTF2B | general transcription factor IIB | -0.0292533 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0290651 |
| FHIT | fragile histidine triad | -0.0289772 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0286749 |
| NOCT | nocturnin | -0.0284842 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.028477 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0283602 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0283457 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0281046 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0280493 |
| IL6ST | interleukin 6 signal transducer | -0.0280034 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0278406 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0278364 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0277647 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.027759 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0277197 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.027714 |
| ARF4 | ADP-ribosylation factor 4 | -0.0276946 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0275494 |
| FUS | FUS RNA binding protein | -0.0275442 |
| RIGI | RNA sensor RIG-I | -0.0275215 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.027174 |
| CERT1 | ceramide transporter 1 | -0.02714 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0269653 |
