| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | 0.0931754 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0889722 |
| ZNF292 | zinc finger protein 292 | 0.0885218 |
| VIM | vimentin | 0.0881074 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0847248 |
| PGK1 | phosphoglycerate kinase 1 | 0.0781991 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0736098 |
| ENO1 | enolase 1, (alpha) | 0.0676761 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0605439 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0595128 |
| OGA | O-GlcNAcase | 0.0578771 |
| COL1A2 | collagen, type I, alpha 2 | 0.0561258 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0554749 |
| RBM39 | RNA binding motif protein 39 | 0.0543804 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0534781 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0524889 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0523245 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.049939 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.049595 |
| ATP13A3 | ATPase type 13A3 | 0.0492727 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0486973 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0484027 |
| XPO1 | exportin 1 | 0.0480613 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0477663 |
| FAM13A | family with sequence similarity 13, member A | 0.0475295 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0471776 |
| PTMA | prothymosin, alpha | 0.0460035 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0456988 |
| FAM20C | family with sequence similarity 20, member C | 0.0432818 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0418923 |
| FMNL2 | formin-like 2 | 0.0417765 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0414542 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0408774 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0404477 |
| CENPF | centromere protein F, 350/400kDa | 0.0392138 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.039196 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.038595 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0384603 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0379385 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0365299 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0360852 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0360224 |
| FLNB | filamin B, beta | 0.0359973 |
| COL1A1 | collagen, type I, alpha 1 | 0.0359793 |
| INSIG2 | insulin induced gene 2 | 0.0355712 |
| AFDN | afadin, adherens junction formation factor | 0.035451 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0354291 |
| TFG | TRK-fused gene | 0.0350359 |
| CDC73 | cell division cycle 73 | 0.0348758 |
| YEATS2 | YEATS domain containing 2 | 0.0340164 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0339692 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0339415 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0337186 |
| ANLN | anillin, actin binding protein | 0.0336428 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0330775 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0326544 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0326255 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0321101 |
| CHSY1 | chondroitin sulfate synthase 1 | 0.0320704 |
| MEF2A | myocyte enhancer factor 2A | 0.0320652 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0315002 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0313 |
| CD109 | CD109 molecule | 0.0310314 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0303794 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0302793 |
| QKI | QKI, KH domain containing, RNA binding | 0.0300125 |
| MYOF | myoferlin | 0.029731 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0296483 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0293764 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0288411 |
| SDC4 | syndecan 4 | 0.028704 |
| YBX1 | Y box binding protein 1 | 0.0286634 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0285861 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0283918 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0282001 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0281811 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0281038 |
| RBM26 | RNA binding motif protein 26 | 0.0279201 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0278937 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0278686 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.027522 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0275031 |
| AFAP1 | actin filament associated protein 1 | 0.027445 |
| RPL4 | ribosomal protein L4 | 0.0273595 |
| RNF145 | ring finger protein 145 | 0.0273493 |
| HELZ | helicase with zinc finger | 0.0269717 |
| ABI1 | abl-interactor 1 | 0.0269663 |
| ANXA2 | annexin A2 | 0.0269604 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.026944 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0268033 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0267993 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0266685 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0262346 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0261028 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0260893 |
| PTK2 | protein tyrosine kinase 2 | 0.0260001 |
| FAM168A | family with sequence similarity 168, member A | 0.0259385 |
| TPM3 | tropomyosin 3 | 0.0258541 |
| USP3 | ubiquitin specific peptidase 3 | 0.0258355 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0256529 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.297593 |
| MT2A | metallothionein 2A | -0.146977 |
| STC1 | stanniocalcin 1 | -0.139751 |
| EGR1 | early growth response 1 | -0.100174 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0884516 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0867666 |
| B2M | beta-2-microglobulin | -0.0806116 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0784701 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0710584 |
| CDH13 | cadherin 13 | -0.0706206 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0696408 |
| FTL | ferritin, light polypeptide | -0.0679203 |
| HLA-B | major histocompatibility complex, class I, B | -0.0669999 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0643828 |
| RPL35A | ribosomal protein L35a | -0.0606949 |
| NAV1 | neuron navigator 1 | -0.0575588 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.056303 |
| HDAC9 | histone deacetylase 9 | -0.0538963 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0531273 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0495255 |
| SP100 | SP100 nuclear antigen | -0.0460634 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0449819 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0439316 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0435488 |
| RPS6 | ribosomal protein S6 | -0.0422267 |
| IL1B | interleukin 1, beta | -0.040189 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0365949 |
| SHISA5 | shisa family member 5 | -0.0363695 |
| PKM | pyruvate kinase, muscle | -0.036131 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0352108 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | -0.0351227 |
| RPL28 | ribosomal protein L28 | -0.0343254 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0342789 |
| FOSL1 | FOS-like antigen 1 | -0.0342699 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0336518 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | -0.0335786 |
| RPS19 | ribosomal protein S19 | -0.0331856 |
| PFN1 | profilin 1 | -0.0326523 |
| MYADM | myeloid-associated differentiation marker | -0.031891 |
| RPS13 | ribosomal protein S13 | -0.0314955 |
| EXT1 | exostosin glycosyltransferase 1 | -0.03138 |
| IER3 | immediate early response 3 | -0.0313008 |
| RPL11 | ribosomal protein L11 | -0.0310261 |
| CD44 | CD44 molecule (Indian blood group) | -0.031004 |
| RPLP1 | ribosomal protein, large, P1 | -0.0309038 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0305823 |
| INTS6 | integrator complex subunit 6 | -0.0304539 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0304128 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0302755 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0299922 |
| TMSB10 | thymosin beta 10 | -0.0296394 |
| HMGA1 | high mobility group AT-hook 1 | -0.0289486 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0288669 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.028724 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0284854 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0281847 |
| RPS11 | ribosomal protein S11 | -0.0280352 |
| MMP2 | matrix metallopeptidase 2 | -0.0277662 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0277577 |
| GLIS3 | GLIS family zinc finger 3 | -0.0277039 |
| CDCP1 | CUB domain containing protein 1 | -0.0276971 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0274679 |
| FHIT | fragile histidine triad | -0.0272783 |
| RPS25 | ribosomal protein S25 | -0.0271786 |
| NDRG1 | N-myc downstream regulated 1 | -0.0271137 |
| KYNU | kynureninase | -0.026719 |
| EML5 | echinoderm microtubule associated protein like 5 | -0.0265396 |
| ADM | adrenomedullin | -0.0265054 |
| NABP1 | nucleic acid binding protein 1 | -0.0263881 |
| EGFR | epidermal growth factor receptor | -0.0258076 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0255419 |
| RPLP2 | ribosomal protein, large, P2 | -0.0254098 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0252255 |
| CCNL1 | cyclin L1 | -0.025207 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0249816 |
| BRD2 | bromodomain containing 2 | -0.0247063 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0245207 |
| RPL34 | ribosomal protein L34 | -0.0244395 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0243926 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0243751 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0242283 |
| TGM2 | transglutaminase 2 | -0.0240728 |
| S100A9 | S100 calcium binding protein A9 | -0.0237836 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0236206 |
| HLA-A | major histocompatibility complex, class I, A | -0.0235355 |
| RPS21 | ribosomal protein S21 | -0.0232684 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0232312 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0230591 |
| PLP2 | proteolipid protein 2 (colonic epithelium-enriched) | -0.0229896 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0229378 |
| RPL32 | ribosomal protein L32 | -0.0228692 |
| RPL31 | ribosomal protein L31 | -0.022766 |
| RPL8 | ribosomal protein L8 | -0.0227263 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0224703 |
| HLA-E | major histocompatibility complex, class I, E | -0.0223948 |
| CCDC138 | coiled-coil domain containing 138 | -0.022251 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0220358 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0218385 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0216471 |
| VCL | vinculin | -0.0216257 |
