Ivabradine (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VGF VGF nerve growth factor inducible 0.150314
PTMA prothymosin, alpha 0.1144
ENO1 enolase 1, (alpha) 0.0888845
RPS3 ribosomal protein S3 0.0763919
FTL ferritin, light polypeptide 0.0644619
RPL37A ribosomal protein L37a 0.061347
MT2A metallothionein 2A 0.0574621
RPS8 ribosomal protein S8 0.0565207
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0423367
LOC112694756 uncharaterized LOC112694756 0.0413443
TENM1 teneurin transmembrane protein 1 0.0404103
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0375965
EIF4A1 eukaryotic translation initiation factor 4A1 0.0364615
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0360829
RPL4 ribosomal protein L4 0.0353501
SET SET nuclear proto-oncogene 0.0349441
CENPF centromere protein F, 350/400kDa 0.0349275
RPLP1 ribosomal protein, large, P1 0.0346349
RPL26 ribosomal protein L26 0.0345833
RPL5 ribosomal protein L5 0.0337764
SMC1A structural maintenance of chromosomes 1A 0.0326004
MCL1 myeloid cell leukemia 1 0.0319874
RPS19 ribosomal protein S19 0.0317471
BHLHE40 basic helix-loop-helix family, member e40 0.031347
TMSB10 thymosin beta 10 0.030475
RPS12 ribosomal protein S12 0.0299436
ASCL1 achaete-scute family bHLH transcription factor 1 0.0295068
RPL23 ribosomal protein L23 0.028535
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0278038
MYH9 myosin, heavy chain 9, non-muscle 0.0267948
PNN pinin, desmosome associated protein 0.0264135
RPS17 ribosomal protein S17 0.026359
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0253752
RPL31 ribosomal protein L31 0.0253393
RPL37 ribosomal protein L37 0.0251571
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0249849
RBM25 RNA binding motif protein 25 0.0248678
FBL fibrillarin 0.0242126
FTH1 ferritin, heavy polypeptide 1 0.0240123
RPS27 ribosomal protein S27 0.0240048
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0237312
RPS16 ribosomal protein S16 0.0237044
PKM pyruvate kinase, muscle 0.0236555
RPL35 ribosomal protein L35 0.0234972
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0232973
GRAMD4 GRAM domain containing 4 0.0232621
RPL30 ribosomal protein L30 0.0228326
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0226663
RPS27A ribosomal protein S27a 0.0225457
RSRC2 arginine/serine-rich coiled-coil 2 0.0224893
CADM1 cell adhesion molecule 1 0.0224275
UBB ubiquitin B 0.0218611
YBX1 Y box binding protein 1 0.0217729
RPS6 ribosomal protein S6 0.0217082
RPL32 ribosomal protein L32 0.0211153
RPL11 ribosomal protein L11 0.0210778
RPL18 ribosomal protein L18 0.0210517
SOX4 SRY (sex determining region Y)-box 4 0.0208113
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.020668
RPL36 ribosomal protein L36 0.0203793
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0200096
SCG2 secretogranin II 0.0199485
KPNB1 karyopherin (importin) beta 1 0.0194609
CKAP5 cytoskeleton associated protein 5 0.0194066
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0193846
B2M beta-2-microglobulin 0.0193545
INHBA inhibin, beta A 0.0193522
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0192826
RPS29 ribosomal protein S29 0.019234
ASXL1 additional sex combs like transcriptional regulator 1 0.0188861
NAP1L1 nucleosome assembly protein 1-like 1 0.0188753
MXI1 MAX interactor 1, dimerization protein 0.0185738
RACK1 receptor for activated C kinase 1 0.0185555
CALCA calcitonin-related polypeptide alpha 0.0183559
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0183446
RPS20 ribosomal protein S20 0.0180888
RPL19 ribosomal protein L19 0.0180682
NAMPT nicotinamide phosphoribosyltransferase 0.0180359
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0179907
LMNA lamin A/C 0.0174872
MATR3 matrin 3 0.0172204
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.017164
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0171523
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0170834
TPM3 tropomyosin 3 0.0169951
ATP5F1E ATP synthase F1 subunit epsilon 0.0167416
IRS2 insulin receptor substrate 2 0.0165997
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0165306
PCBP2 poly(rC) binding protein 2 0.0163311
BRD4 bromodomain containing 4 0.0163288
SMOC1 SPARC related modular calcium binding 1 0.0162928
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0162904
PER1 period circadian clock 1 0.0161869
RPL36AL ribosomal protein L36a-like 0.0160592
RPL3 ribosomal protein L3 0.0159942
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0159218
SEZ6L2 seizure related 6 homolog (mouse)-like 2 0.0157346
RPL7A ribosomal protein L7a 0.0157337
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0156713
KTN1 kinectin 1 (kinesin receptor) 0.0156427

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.113703
PDE10A phosphodiesterase 10A -0.0825193
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0622942
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0554776
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.054471
GPC6 glypican 6 -0.0533683
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0506274
SNAP25 synaptosomal-associated protein, 25kDa -0.0472979
RIMS2 regulating synaptic membrane exocytosis 2 -0.0471995
FGF14 fibroblast growth factor 14 -0.0467283
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0454046
ESRRG estrogen-related receptor gamma -0.0435887
SYT1 synaptotagmin I -0.0432809
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0406762
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.038199
PEG10 paternally expressed 10 -0.037954
TSHZ2 teashirt zinc finger homeobox 2 -0.0377022
PDIA3 protein disulfide isomerase family A, member 3 -0.0362641
PEX5L peroxisomal biogenesis factor 5-like -0.0361607
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0339869
RIT2 Ras-like without CAAX 2 -0.0333216
PDE4B phosphodiesterase 4B, cAMP-specific -0.0323359
NCKAP5 NCK-associated protein 5 -0.0322232
ZBTB20 zinc finger and BTB domain containing 20 -0.0315471
SNTG1 syntrophin, gamma 1 -0.030577
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0301283
PELI2 pellino E3 ubiquitin protein ligase family member 2 -0.0297675
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0297292
DGKB diacylglycerol kinase, beta 90kDa -0.0292417
NRG1 neuregulin 1 -0.0291909
SMYD3 SET and MYND domain containing 3 -0.0289159
TENT5A terminal nucleotidyltransferase 5A -0.0284927
JAZF1 JAZF zinc finger 1 -0.0282789
ADGRL2 adhesion G protein-coupled receptor L2 -0.0279
ZNF804A zinc finger protein 804A -0.0275163
PTCHD4 patched domain containing 4 -0.0274439
KCTD8 potassium channel tetramerization domain containing 8 -0.0272806
SLC35F4 solute carrier family 35, member F4 -0.026568
BCL2 B-cell CLL/lymphoma 2 -0.0260625
CNKSR3 CNKSR family member 3 -0.0252535
GPC5 glypican 5 -0.0244109
EEF1G eukaryotic translation elongation factor 1 gamma -0.0239077
SYT4 synaptotagmin IV -0.0238597
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0237417
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0234648
NBEA neurobeachin -0.0233968
GMDS GDP-mannose 4,6-dehydratase -0.0226104
EGR1 early growth response 1 -0.0224316
ATF6 activating transcription factor 6 -0.0220931
RPTOR regulatory associated protein of MTOR, complex 1 -0.021102
NBAS neuroblastoma amplified sequence -0.0205768
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0205206
ANKRD17 ankyrin repeat domain 17 -0.0201905
ADGRL3 adhesion G protein-coupled receptor L3 -0.0195978
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0195189
AUTS2 autism susceptibility candidate 2 -0.0193222
ST18 suppression of tumorigenicity 18, zinc finger -0.0192742
EFNA5 ephrin-A5 -0.0191865
DTNA dystrobrevin, alpha -0.0191345
TOX thymocyte selection-associated high mobility group box -0.0191088
NOVA1 neuro-oncological ventral antigen 1 -0.018967
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0189115
DACH1 dachshund family transcription factor 1 -0.0189078
COL22A1 collagen, type XXII, alpha 1 -0.0186613
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0185806
EPHA6 EPH receptor A6 -0.0182383
PCSK1 proprotein convertase subtilisin/kexin type 1 -0.0181456
KIF26B kinesin family member 26B -0.0180016
CSMD3 CUB and Sushi multiple domains 3 -0.0177837
PFN1 profilin 1 -0.0176909
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0175939
TBC1D5 TBC1 domain family, member 5 -0.0174953
GSE1 Gse1 coiled-coil protein -0.0173616
ARHGAP26 Rho GTPase activating protein 26 -0.0173544
NLGN1 neuroligin 1 -0.0172913
CAPRIN1 cell cycle associated protein 1 -0.0170868
FNDC3A fibronectin type III domain containing 3A -0.0170422
SCFD2 sec1 family domain containing 2 -0.0168396
P4HB prolyl 4-hydroxylase, beta polypeptide -0.016787
NRXN1 neurexin 1 -0.0167473
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0167201
KIAA0825 KIAA0825 -0.0166853
FKBP9 FK506 binding protein 9, 63 kDa -0.0166633
RGS7 regulator of G-protein signaling 7 -0.0162378
FAF1 Fas (TNFRSF6) associated factor 1 -0.016188
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0161791
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0160907
NF1 neurofibromin 1 -0.0159629
POU2F1 POU class 2 homeobox 1 -0.0157349
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0157141
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0155448
AOPEP aminopeptidase O (putative) -0.015394
ZMAT4 zinc finger, matrin-type 4 -0.0153829
MIPOL1 mirror-image polydactyly 1 -0.0152472
NELL1 NEL-like 1 (chicken) -0.0151738
CCSER1 coiled-coil serine-rich protein 1 -0.0149915
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.0149227
FAT1 FAT atypical cadherin 1 -0.0148269
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0148245
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0148132