| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.125852 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.085181 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0793161 |
| RPS3 | ribosomal protein S3 | 0.0783318 |
| RPL3 | ribosomal protein L3 | 0.0643563 |
| ENO1 | enolase 1, (alpha) | 0.0583812 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.055654 |
| POTEF | POTE ankyrin domain family, member F | 0.0535614 |
| PCBP2 | poly(rC) binding protein 2 | 0.0530325 |
| TPM3 | tropomyosin 3 | 0.0507709 |
| MSN | moesin | 0.0503316 |
| FLNB | filamin B, beta | 0.0498669 |
| NOTCH2 | notch 2 | 0.0413963 |
| RPS12 | ribosomal protein S12 | 0.0403267 |
| MCL1 | myeloid cell leukemia 1 | 0.0361048 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0359583 |
| PTMA | prothymosin, alpha | 0.0358058 |
| VIM | vimentin | 0.0353929 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0348006 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0340446 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0328592 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.031524 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0311658 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0299712 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0290601 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0279698 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.027852 |
| SET | SET nuclear proto-oncogene | 0.0274714 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0273725 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0272656 |
| PRELID2 | PRELI domain containing 2 | 0.0272623 |
| AHNAK | AHNAK nucleoprotein | 0.0271651 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0269625 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0267789 |
| FMNL2 | formin-like 2 | 0.026471 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0258643 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.025117 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0249141 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0247322 |
| VEGFA | vascular endothelial growth factor A | 0.0247115 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0246121 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0245707 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0242283 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0241032 |
| CENPF | centromere protein F, 350/400kDa | 0.0239913 |
| ASPH | aspartate beta-hydroxylase | 0.023969 |
| DIAPH1 | diaphanous-related formin 1 | 0.0237562 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.023745 |
| ANGPTL4 | angiopoietin-like 4 | 0.0234025 |
| BCAP31 | B-cell receptor-associated protein 31 | 0.0232933 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0231418 |
| MSI2 | musashi RNA-binding protein 2 | 0.0229506 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0227462 |
| FAM13A | family with sequence similarity 13, member A | 0.0223276 |
| FAM120A | family with sequence similarity 120A | 0.022304 |
| ANXA5 | annexin A5 | 0.0214453 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.021402 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0213314 |
| BIRC7 | baculoviral IAP repeat containing 7 | 0.0209826 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0209033 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0204805 |
| ZNF292 | zinc finger protein 292 | 0.0203638 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0203627 |
| FAM219A | family with sequence similarity 219, member A | 0.0202584 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0195371 |
| EZR | ezrin | 0.0193249 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.019228 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.019098 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.018867 |
| NGLY1 | N-glycanase 1 | 0.0188616 |
| B2M | beta-2-microglobulin | 0.0187095 |
| CEP250 | centrosomal protein 250kDa | 0.0187094 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0186777 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0186095 |
| RPL37A | ribosomal protein L37a | 0.0185888 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0183986 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0183624 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0182946 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0181447 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0180945 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0179758 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0177873 |
| RNF149 | ring finger protein 149 | 0.017771 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0176531 |
| BBX | bobby sox homolog (Drosophila) | 0.0175907 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0175354 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0175244 |
| CORO1C | coronin, actin binding protein, 1C | 0.0174373 |
| PKM | pyruvate kinase, muscle | 0.0171809 |
| MMP12 | matrix metallopeptidase 12 | 0.0168288 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0167456 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0167297 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0165804 |
| INSIG2 | insulin induced gene 2 | 0.0165602 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0165056 |
| VMP1 | vacuole membrane protein 1 | 0.0163276 |
| RANGAP1 | Ran GTPase activating protein 1 | 0.0162564 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0160514 |
| TNS1 | tensin 1 | 0.0157894 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0156751 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FMN1 | formin 1 | -0.203454 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.178972 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.171505 |
| LSAMP | limbic system-associated membrane protein | -0.119248 |
| CCND1 | cyclin D1 | -0.0886592 |
| NRG3 | neuregulin 3 | -0.0869848 |
| FRMD4A | FERM domain containing 4A | -0.079961 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0652821 |
| FRMD5 | FERM domain containing 5 | -0.0606819 |
| RAB7A | RAB7A, member RAS oncogene family | -0.059966 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0592525 |
| FN1 | fibronectin 1 | -0.0560965 |
| PMEL | premelanosome protein | -0.0505149 |
| SQSTM1 | sequestosome 1 | -0.049254 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0464371 |
| HDAC9 | histone deacetylase 9 | -0.0461527 |
| RPL35A | ribosomal protein L35a | -0.0448816 |
| COMMD10 | COMM domain containing 10 | -0.0408048 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0395567 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0386821 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0376756 |
| CDK6 | cyclin-dependent kinase 6 | -0.0369766 |
| FHIT | fragile histidine triad | -0.0365248 |
| TNNC1 | troponin C type 1 (slow) | -0.0348802 |
| EMP1 | epithelial membrane protein 1 | -0.0334753 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0334331 |
| NF1 | neurofibromin 1 | -0.0319517 |
| HMGA1 | high mobility group AT-hook 1 | -0.0318439 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0314445 |
| TENM1 | teneurin transmembrane protein 1 | -0.0313076 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0301923 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0300678 |
| SFTPA2 | surfactant protein A2 | -0.0299565 |
| RPS24 | ribosomal protein S24 | -0.0298674 |
| PGK1 | phosphoglycerate kinase 1 | -0.0295196 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0288789 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0288498 |
| TUBB | tubulin, beta class I | -0.0287799 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0284929 |
| RPL38 | ribosomal protein L38 | -0.0280197 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0279462 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0277776 |
| FUS | FUS RNA binding protein | -0.0274204 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0273939 |
| CTSD | cathepsin D | -0.0272273 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0270296 |
| RPS6 | ribosomal protein S6 | -0.0266154 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0263658 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0261255 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0259895 |
| SP100 | SP100 nuclear antigen | -0.0253829 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0250837 |
| PLSCR1 | phospholipid scramblase 1 | -0.0249752 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0249394 |
| CD44 | CD44 molecule (Indian blood group) | -0.0248878 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0245047 |
| CLINT1 | clathrin interactor 1 | -0.024476 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0243735 |
| RPL34 | ribosomal protein L34 | -0.0243462 |
| RIGI | RNA sensor RIG-I | -0.0242102 |
| LDHA | lactate dehydrogenase A | -0.0240186 |
| RRBP1 | ribosome binding protein 1 | -0.0238418 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0238356 |
| HDAC8 | histone deacetylase 8 | -0.023659 |
| FARP2 | FERM, RhoGEF and pleckstrin domain protein 2 | -0.0236346 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0233665 |
| APOD | apolipoprotein D | -0.0231439 |
| HLA-B | major histocompatibility complex, class I, B | -0.0229925 |
| ARF1 | ADP-ribosylation factor 1 | -0.0224556 |
| UBC | ubiquitin C | -0.0223241 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0223126 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0214791 |
| TCF20 | transcription factor 20 (AR1) | -0.0214727 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.0212607 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0211775 |
| RPL8 | ribosomal protein L8 | -0.0211684 |
| TMEM263 | transmembrane protein 263 | -0.0211667 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0210323 |
| ERBIN | erbb2 interacting protein | -0.0209787 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0208612 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0207508 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0204112 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0203645 |
| GNS | glucosamine (N-acetyl)-6-sulfatase | -0.020218 |
| TASOR2 | transcription activation suppressor family member 2 | -0.020074 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.0200248 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0198388 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.019804 |
| TRIM56 | tripartite motif containing 56 | -0.0196795 |
| ATF6 | activating transcription factor 6 | -0.0196754 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.019632 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0195292 |
| RPS21 | ribosomal protein S21 | -0.0194899 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0193507 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0193401 |
| PLCB4 | phospholipase C, beta 4 | -0.0193008 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0192847 |
| BPTF | bromodomain PHD finger transcription factor | -0.0191033 |
| SPAG9 | sperm associated antigen 9 | -0.0189997 |
| HMGB1 | high mobility group box 1 | -0.0187965 |
