| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.146487 |
| B2M | beta-2-microglobulin | 0.114323 |
| NDRG1 | N-myc downstream regulated 1 | 0.0948225 |
| COL1A2 | collagen, type I, alpha 2 | 0.0903016 |
| PTMA | prothymosin, alpha | 0.0795568 |
| ENO1 | enolase 1, (alpha) | 0.0690854 |
| ZNF292 | zinc finger protein 292 | 0.0682126 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0670325 |
| COL1A1 | collagen, type I, alpha 1 | 0.0603113 |
| IGF2 | insulin-like growth factor 2 | 0.0581991 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0580001 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0577047 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0571595 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0521136 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0507408 |
| PTK2 | protein tyrosine kinase 2 | 0.0486932 |
| SDC4 | syndecan 4 | 0.0482801 |
| COPA | coatomer protein complex, subunit alpha | 0.0481226 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.048038 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0479552 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0479264 |
| ANXA2 | annexin A2 | 0.0475284 |
| PGK1 | phosphoglycerate kinase 1 | 0.0464527 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0464206 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0464042 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.046047 |
| CADM1 | cell adhesion molecule 1 | 0.0456772 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | 0.0456294 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.045507 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0447984 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0434064 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0419258 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0396849 |
| GOLGA4 | golgin A4 | 0.039071 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0387266 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0379269 |
| PRKCA | protein kinase C, alpha | 0.037922 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0374829 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0371674 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0368103 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0367739 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.036697 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0366861 |
| FAM13A | family with sequence similarity 13, member A | 0.0364485 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0363349 |
| SEC24D | SEC24 family member D | 0.0357999 |
| LDHA | lactate dehydrogenase A | 0.0356628 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0356394 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0356314 |
| ANXA5 | annexin A5 | 0.0353828 |
| UBC | ubiquitin C | 0.0352823 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0351938 |
| RBM39 | RNA binding motif protein 39 | 0.0351717 |
| ZNF644 | zinc finger protein 644 | 0.035074 |
| AHNAK | AHNAK nucleoprotein | 0.0350511 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0350263 |
| PFKP | phosphofructokinase, platelet | 0.0344988 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0340752 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0334322 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0332754 |
| KIF5B | kinesin family member 5B | 0.0332659 |
| YBX1 | Y box binding protein 1 | 0.0331202 |
| RANBP2 | RAN binding protein 2 | 0.0330234 |
| IL6 | interleukin 6 | 0.0328047 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0327964 |
| WDR41 | WD repeat domain 41 | 0.032745 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0326979 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0324428 |
| DSTN | destrin (actin depolymerizing factor) | 0.0323951 |
| YME1L1 | YME1-like 1 ATPase | 0.0318052 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0317136 |
| LOXL2 | lysyl oxidase-like 2 | 0.0314453 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0312571 |
| TXNRD1 | thioredoxin reductase 1 | 0.030655 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0305839 |
| RPS3 | ribosomal protein S3 | 0.0305629 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.03015 |
| ZNF395 | zinc finger protein 395 | 0.0297917 |
| AUTS2 | autism susceptibility candidate 2 | 0.0295639 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.028899 |
| PERP | PERP, TP53 apoptosis effector | 0.0288954 |
| CABIN1 | calcineurin binding protein 1 | 0.0287704 |
| MT2A | metallothionein 2A | 0.0286766 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0286163 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0282904 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0282057 |
| SUCO | SUN domain containing ossification factor | 0.0282007 |
| H3-3B | H3.3 histone B | 0.0281208 |
| TNPO1 | transportin 1 | 0.0273058 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0271639 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0270885 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0268276 |
| KAZN | kazrin, periplakin interacting protein | 0.0267539 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.026646 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0266057 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0265777 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0264782 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0263885 |
| TMEM87A | transmembrane protein 87A | 0.0260125 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0259563 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.327475 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152347 |
| FN1 | fibronectin 1 | -0.119575 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.117743 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0930724 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0816258 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0629468 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0609047 |
| ASPH | aspartate beta-hydroxylase | -0.0604825 |
| SMYD3 | SET and MYND domain containing 3 | -0.0578329 |
| CALD1 | caldesmon 1 | -0.0565648 |
| LOX | lysyl oxidase | -0.0548786 |
| HLA-B | major histocompatibility complex, class I, B | -0.0526401 |
| C1D | C1D nuclear receptor corepressor | -0.0521371 |
| CCDC88A | coiled-coil domain containing 88A | -0.0515265 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0502449 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0494496 |
| PDE10A | phosphodiesterase 10A | -0.0447388 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0442658 |
| ERBIN | erbb2 interacting protein | -0.0412421 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0395473 |
| CD99 | CD99 molecule | -0.0388999 |
| PKM | pyruvate kinase, muscle | -0.0384691 |
| TNS3 | tensin 3 | -0.0382346 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0378381 |
| OSMR | oncostatin M receptor | -0.0371694 |
| FTL | ferritin, light polypeptide | -0.0355122 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0355118 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0352754 |
| MAP1B | microtubule-associated protein 1B | -0.0351964 |
| MT1X | metallothionein 1X | -0.0344128 |
| MYOF | myoferlin | -0.0341629 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0341009 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0339436 |
| VCL | vinculin | -0.0337385 |
| HDAC9 | histone deacetylase 9 | -0.0335567 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0334445 |
| USP34 | ubiquitin specific peptidase 34 | -0.0325664 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0324043 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0323078 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0318467 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0313934 |
| PRKCSH | protein kinase C substrate 80K-H | -0.0312141 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0308967 |
| CLIC4 | chloride intracellular channel 4 | -0.0305976 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0305661 |
| CADM2 | cell adhesion molecule 2 | -0.0305377 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0304248 |
| ATF6 | activating transcription factor 6 | -0.030407 |
| ITGAV | integrin, alpha V | -0.0302749 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | -0.0300601 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.029665 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0296126 |
| PHKB | phosphorylase kinase, beta | -0.0294895 |
| GLIS3 | GLIS family zinc finger 3 | -0.0292636 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0291717 |
| CDK6 | cyclin-dependent kinase 6 | -0.0291355 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0288047 |
| USP15 | ubiquitin specific peptidase 15 | -0.0284063 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.0279422 |
| BPTF | bromodomain PHD finger transcription factor | -0.0272564 |
| SCFD2 | sec1 family domain containing 2 | -0.0270883 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0270611 |
| RLF | rearranged L-myc fusion | -0.0269081 |
| RIN2 | Ras and Rab interactor 2 | -0.0267474 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0266907 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0259775 |
| S100A10 | S100 calcium binding protein A10 | -0.0259244 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0258275 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0254021 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0252074 |
| JAZF1 | JAZF zinc finger 1 | -0.0250452 |
| DYM | dymeclin | -0.0249927 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0247033 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.024618 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0245333 |
| VEGFA | vascular endothelial growth factor A | -0.0243115 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0241649 |
| S100A6 | S100 calcium binding protein A6 | -0.0240602 |
| NUP98 | nucleoporin 98kDa | -0.0236567 |
| NRG1 | neuregulin 1 | -0.0234547 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0234393 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0233892 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0232721 |
| MTDH | metadherin | -0.0225932 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0225597 |
| RPL34 | ribosomal protein L34 | -0.022512 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0223507 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.02233 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | -0.0222829 |
| SEPTIN9 | septin 9 | -0.0222603 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | -0.0222389 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0221688 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.022103 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0220469 |
| FBXO34 | F-box protein 34 | -0.0220435 |
| STAM2 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | -0.0219699 |
| ARF1 | ADP-ribosylation factor 1 | -0.0219396 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0218996 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0218788 |
