| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SET | SET nuclear proto-oncogene | 0.0934629 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0925153 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0828266 |
| ENO1 | enolase 1, (alpha) | 0.0742948 |
| NUP58 | nucleoporin 58 | 0.0681498 |
| ZNF292 | zinc finger protein 292 | 0.0664237 |
| ASPH | aspartate beta-hydroxylase | 0.0644935 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0638598 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0630929 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0595237 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.056831 |
| MSN | moesin | 0.0539795 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0519967 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.051799 |
| RPS3 | ribosomal protein S3 | 0.0506876 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0503469 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0500274 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0495655 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0489353 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0457555 |
| PCBP2 | poly(rC) binding protein 2 | 0.0453849 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0449781 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0438879 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0434553 |
| MT2A | metallothionein 2A | 0.0432104 |
| CENPF | centromere protein F, 350/400kDa | 0.0415685 |
| RPS12 | ribosomal protein S12 | 0.0397987 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0395355 |
| ECT2 | epithelial cell transforming 2 | 0.0392806 |
| DIAPH3 | diaphanous-related formin 3 | 0.0386308 |
| DERA | deoxyribose-phosphate aldolase (putative) | 0.0378497 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0377389 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0368855 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0366708 |
| APP | amyloid beta (A4) precursor protein | 0.0365289 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0364748 |
| NBEA | neurobeachin | 0.03583 |
| POTEF | POTE ankyrin domain family, member F | 0.0358163 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0354659 |
| RPL23 | ribosomal protein L23 | 0.0354395 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0352402 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0351679 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0350879 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0346502 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0344479 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0343972 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0341036 |
| TTLL10 | tubulin tyrosine ligase-like family member 10 | 0.033078 |
| GOLGB1 | golgin B1 | 0.0330442 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.032398 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0322539 |
| TPM4 | tropomyosin 4 | 0.0318736 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0315301 |
| RNF145 | ring finger protein 145 | 0.0314417 |
| BRD4 | bromodomain containing 4 | 0.0309392 |
| GOLGA2 | golgin A2 | 0.0308671 |
| ATP13A3 | ATPase type 13A3 | 0.0308652 |
| CANX | calnexin | 0.0302918 |
| CDC42BPB | CDC42 binding protein kinase beta (DMPK-like) | 0.0302785 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.030219 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0299585 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0299531 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0298367 |
| HYOU1 | hypoxia up-regulated 1 | 0.0297567 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0294376 |
| TPX2 | TPX2, microtubule-associated | 0.0290707 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0288263 |
| PKM | pyruvate kinase, muscle | 0.0283953 |
| TPR | translocated promoter region, nuclear basket protein | 0.0282754 |
| WDR43 | WD repeat domain 43 | 0.0281238 |
| TPM3 | tropomyosin 3 | 0.0281192 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.028097 |
| LDHA | lactate dehydrogenase A | 0.0280337 |
| CEP70 | centrosomal protein 70kDa | 0.0279936 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0278385 |
| NAV2 | neuron navigator 2 | 0.0277021 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0274871 |
| BMS1 | BMS1 ribosome biogenesis factor | 0.0274452 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0273965 |
| PHF20 | PHD finger protein 20 | 0.0273912 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0270669 |
| SEPTIN2 | septin 2 | 0.0270308 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0269856 |
| DSCAM | Down syndrome cell adhesion molecule | 0.026878 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0267876 |
| RBM33 | RNA binding motif protein 33 | 0.0265686 |
| NKTR | natural killer cell triggering receptor | 0.02653 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.026472 |
| RPL4 | ribosomal protein L4 | 0.0264171 |
| ZFR | zinc finger RNA binding protein | 0.0263674 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0263513 |
| COG5 | component of oligomeric golgi complex 5 | 0.0263116 |
| PTMA | prothymosin, alpha | 0.0261482 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0260187 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0260064 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.0259381 |
| ANLN | anillin, actin binding protein | 0.0257906 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0257073 |
| YAP1 | Yes-associated protein 1 | 0.0255854 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0255431 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.309618 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0991219 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0925649 |
| INTS6 | integrator complex subunit 6 | -0.0817989 |
| HMGA2 | high mobility group AT-hook 2 | -0.0813085 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0645167 |
| EGR1 | early growth response 1 | -0.0599726 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0579505 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.051105 |
| IER3 | immediate early response 3 | -0.0495523 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0491884 |
| NLK | nemo-like kinase | -0.0482642 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0482411 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0474606 |
| SLC38A2 | solute carrier family 38, member 2 | -0.046505 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0460852 |
| GNAS | GNAS complex locus | -0.0438964 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0433827 |
| IGF2 | insulin-like growth factor 2 | -0.0427396 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.041177 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.040784 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.040569 |
| PRR16 | proline rich 16 | -0.0402546 |
| RIGI | RNA sensor RIG-I | -0.0401873 |
| ANXA2 | annexin A2 | -0.039946 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0399235 |
| SVIL | supervillin | -0.0397862 |
| SETX | senataxin | -0.0396364 |
| SQSTM1 | sequestosome 1 | -0.0390645 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0387339 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0384662 |
| RASAL2 | RAS protein activator like 2 | -0.0380137 |
| ERBIN | erbb2 interacting protein | -0.0376328 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.037592 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0374761 |
| ATM | ATM serine/threonine kinase | -0.037304 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0366536 |
| TMSB10 | thymosin beta 10 | -0.0366437 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0351114 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0350097 |
| RAI14 | retinoic acid induced 14 | -0.0346269 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0340473 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.033823 |
| COL5A1 | collagen, type V, alpha 1 | -0.0335287 |
| AEBP2 | AE binding protein 2 | -0.0331935 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0329728 |
| JMJD1C | jumonji domain containing 1C | -0.0329527 |
| PRSS23 | protease, serine, 23 | -0.0328541 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0326004 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | -0.0325875 |
| TBCA | tubulin folding cofactor A | -0.0321045 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.03138 |
| ATG7 | autophagy related 7 | -0.0312865 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0308887 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0306608 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0302227 |
| TMEM263 | transmembrane protein 263 | -0.030164 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0299911 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0296099 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0295413 |
| RTN3 | reticulon 3 | -0.0288637 |
| NABP1 | nucleic acid binding protein 1 | -0.0286818 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0284727 |
| MAP1B | microtubule-associated protein 1B | -0.0284125 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0283787 |
| EFNA5 | ephrin-A5 | -0.0283017 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0280047 |
| GPC6 | glypican 6 | -0.0279681 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0278653 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0276961 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0274112 |
| PLCB4 | phospholipase C, beta 4 | -0.0273756 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0271373 |
| CCND1 | cyclin D1 | -0.0270586 |
| ZFHX3 | zinc finger homeobox 3 | -0.0268068 |
| MYO1E | myosin IE | -0.0267555 |
| SMYD3 | SET and MYND domain containing 3 | -0.0267449 |
| TMEM123 | transmembrane protein 123 | -0.0264633 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0261789 |
| FOXO3 | forkhead box O3 | -0.0261679 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0261187 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0260696 |
| STK4 | serine/threonine kinase 4 | -0.0260487 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0259859 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0259136 |
| PTK2 | protein tyrosine kinase 2 | -0.0257904 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0257563 |
| CCNI | cyclin I | -0.0256431 |
| PRKCA | protein kinase C, alpha | -0.0255033 |
| TVP23C-CDRT4 | TVP23C-CDRT4 readthrough | -0.0254363 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0253002 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0252112 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0250339 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.024952 |
| EGFR | epidermal growth factor receptor | -0.0248853 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0248783 |
| ITGB4 | integrin, beta 4 | -0.024765 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | -0.024488 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0243252 |
| GOLGA4 | golgin A4 | -0.0242431 |
