| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ivabradine (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.100488 |
| SMOX | spermine oxidase | 0.0691294 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0651625 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0586711 |
| SMAD3 | SMAD family member 3 | 0.0550541 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0520378 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0496112 |
| OSMR | oncostatin M receptor | 0.0495395 |
| AHR | aryl hydrocarbon receptor | 0.0485717 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0477741 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.043975 |
| ETV6 | ets variant 6 | 0.0418815 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0406755 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0403762 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0400772 |
| VEGFA | vascular endothelial growth factor A | 0.0385148 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0380321 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0356985 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0352641 |
| WDR26 | WD repeat domain 26 | 0.0340505 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0324108 |
| CAB39 | calcium binding protein 39 | 0.0320155 |
| RPS12 | ribosomal protein S12 | 0.0319795 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0318167 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.031712 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.031004 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0306576 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0301025 |
| RUNX2 | runt-related transcription factor 2 | 0.0298603 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0293338 |
| TMEM165 | transmembrane protein 165 | 0.0289734 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0286989 |
| TXNIP | thioredoxin interacting protein | 0.0284588 |
| ETNK1 | ethanolamine kinase 1 | 0.0284256 |
| PCBP2 | poly(rC) binding protein 2 | 0.0279203 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.027751 |
| ADAR | adenosine deaminase, RNA-specific | 0.0276722 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0276417 |
| ITGA1 | integrin, alpha 1 | 0.0273688 |
| DST | dystonin | 0.0268926 |
| OGA | O-GlcNAcase | 0.0257733 |
| SMYD3 | SET and MYND domain containing 3 | 0.0255079 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.0254209 |
| ITGB5 | integrin, beta 5 | 0.0254155 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0253689 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0252403 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0248569 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0248475 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.024687 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0244796 |
| TPM3 | tropomyosin 3 | 0.024449 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0240375 |
| HDGF | hepatoma-derived growth factor | 0.0238737 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0237571 |
| PLPP6 | phospholipid phosphatase 6 | 0.023583 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0234236 |
| RPL37A | ribosomal protein L37a | 0.0231374 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0231213 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0230563 |
| TMEM156 | transmembrane protein 156 | 0.0228524 |
| CD44 | CD44 molecule (Indian blood group) | 0.0228475 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0228174 |
| FBXO32 | F-box protein 32 | 0.0226404 |
| PRELID2 | PRELI domain containing 2 | 0.0224236 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0224173 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0223493 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0218914 |
| GLIS3 | GLIS family zinc finger 3 | 0.0218006 |
| CENPF | centromere protein F, 350/400kDa | 0.0217089 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0216505 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0213142 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0212802 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0211692 |
| PKM | pyruvate kinase, muscle | 0.0211351 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0210133 |
| ADD3 | adducin 3 (gamma) | 0.0209941 |
| FAM20C | family with sequence similarity 20, member C | 0.0209533 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.020823 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0207631 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0205801 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0205222 |
| SYNJ2 | synaptojanin 2 | 0.020482 |
| UBXN4 | UBX domain protein 4 | 0.020462 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0202241 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0201954 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0201886 |
| PELO | pelota homolog (Drosophila) | 0.0201185 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0200355 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0199712 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0199164 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0198328 |
| TLN1 | talin 1 | 0.0195865 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0195364 |
| RPS3 | ribosomal protein S3 | 0.0194553 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0193637 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0191892 |
| AFDN | afadin, adherens junction formation factor | 0.0189326 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0189248 |
| SLTM | SAFB-like, transcription modulator | 0.0188984 |
| ZNF638 | zinc finger protein 638 | 0.0188295 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.266721 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.186076 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.178434 |
| NRG1 | neuregulin 1 | -0.137105 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.110619 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0995401 |
| FN1 | fibronectin 1 | -0.0974373 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0768758 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0696713 |
| H1-0 | H1.0 linker histone | -0.0662092 |
| PTMA | prothymosin, alpha | -0.0617836 |
| RPL35A | ribosomal protein L35a | -0.0509387 |
| CANX | calnexin | -0.0494207 |
| TMSB10 | thymosin beta 10 | -0.0490496 |
| RPS6 | ribosomal protein S6 | -0.0485978 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0485701 |
| IER3 | immediate early response 3 | -0.047386 |
| FTL | ferritin, light polypeptide | -0.0473076 |
| HLA-B | major histocompatibility complex, class I, B | -0.0466373 |
| RPS24 | ribosomal protein S24 | -0.0437782 |
| INTS6 | integrator complex subunit 6 | -0.0410333 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0409773 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.038569 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0375917 |
| TMEM263 | transmembrane protein 263 | -0.0370378 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0369855 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0367621 |
| RPL34 | ribosomal protein L34 | -0.0364082 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0361059 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0359177 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0358882 |
| S100A10 | S100 calcium binding protein A10 | -0.0348501 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0341305 |
| RHEB | Ras homolog enriched in brain | -0.033305 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0330535 |
| ARF1 | ADP-ribosylation factor 1 | -0.0329755 |
| SQSTM1 | sequestosome 1 | -0.0328029 |
| RPL12 | ribosomal protein L12 | -0.0320753 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0319523 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0317905 |
| FBXO11 | F-box protein 11 | -0.0316072 |
| VCL | vinculin | -0.0312137 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0310591 |
| PTK2 | protein tyrosine kinase 2 | -0.0308308 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0306624 |
| TMSB4X | thymosin beta 4, X-linked | -0.0302315 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.02947 |
| LMNA | lamin A/C | -0.0292114 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0291789 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.028858 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0288564 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0287159 |
| ASPH | aspartate beta-hydroxylase | -0.0281954 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0279917 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0278718 |
| EMP1 | epithelial membrane protein 1 | -0.0276828 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.027409 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0272728 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.026756 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0266721 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.0263863 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0262207 |
| EGR1 | early growth response 1 | -0.0260452 |
| MORF4L2 | mortality factor 4 like 2 | -0.0253525 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0251432 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0249108 |
| CTSD | cathepsin D | -0.0248624 |
| FUS | FUS RNA binding protein | -0.0248552 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0247967 |
| UBC | ubiquitin C | -0.024529 |
| ATF6 | activating transcription factor 6 | -0.0243796 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0240031 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0239388 |
| QKI | QKI, KH domain containing, RNA binding | -0.02381 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0238041 |
| TPI1 | triosephosphate isomerase 1 | -0.0237401 |
| HMGA1 | high mobility group AT-hook 1 | -0.0234678 |
| MAP1B | microtubule-associated protein 1B | -0.0232759 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0232043 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0230802 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0229826 |
| ATF3 | activating transcription factor 3 | -0.0228578 |
| PALLD | palladin, cytoskeletal associated protein | -0.0228176 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0226734 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0224441 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0221075 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0220672 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0217305 |
| RPL38 | ribosomal protein L38 | -0.0217299 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0215867 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0215134 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0213856 |
| AEBP2 | AE binding protein 2 | -0.0211818 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0211374 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0210928 |
| HMGB1 | high mobility group box 1 | -0.0209035 |
| RPS5 | ribosomal protein S5 | -0.0208038 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0207555 |
| JUN | jun proto-oncogene | -0.0206832 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0205938 |
