| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ivabradine (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ivabradine (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.117648 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0973185 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0863705 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0755822 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0642082 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0629277 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0628162 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.059497 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0543981 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0507983 |
| RPS3 | ribosomal protein S3 | 0.0497154 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0491534 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0491122 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0458157 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0456052 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0448181 |
| TMSB4X | thymosin beta 4, X-linked | 0.0437542 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0425612 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0419769 |
| RPS12 | ribosomal protein S12 | 0.0410627 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0406458 |
| NCKAP1 | NCK-associated protein 1 | 0.0405001 |
| PCBP2 | poly(rC) binding protein 2 | 0.03934 |
| SET | SET nuclear proto-oncogene | 0.03903 |
| DIAPH1 | diaphanous-related formin 1 | 0.0384959 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0381399 |
| SNX9 | sorting nexin 9 | 0.0375601 |
| MED13L | mediator complex subunit 13-like | 0.0373625 |
| RPL3 | ribosomal protein L3 | 0.0360977 |
| POTEF | POTE ankyrin domain family, member F | 0.0351402 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0348599 |
| FAM3C | family with sequence similarity 3, member C | 0.034854 |
| DCUN1D3 | DCN1, defective in cullin neddylation 1, domain containing 3 | 0.0347615 |
| RPL4 | ribosomal protein L4 | 0.0345602 |
| MATR3 | matrin 3 | 0.0345088 |
| SDC4 | syndecan 4 | 0.0341809 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.034128 |
| OGA | O-GlcNAcase | 0.0339641 |
| AHNAK | AHNAK nucleoprotein | 0.033836 |
| AFDN | afadin, adherens junction formation factor | 0.0337312 |
| TMEM41B | transmembrane protein 41B | 0.0334909 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0327979 |
| ANXA11 | annexin A11 | 0.0326951 |
| TPM4 | tropomyosin 4 | 0.0323582 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.03219 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0310271 |
| ACTG1 | actin gamma 1 | 0.0299618 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0299478 |
| RNF149 | ring finger protein 149 | 0.0299265 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0294821 |
| SERINC3 | serine incorporator 3 | 0.0294528 |
| MYOF | myoferlin | 0.0293009 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0291984 |
| ZNF148 | zinc finger protein 148 | 0.0291365 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0291252 |
| NEK7 | NIMA-related kinase 7 | 0.0291179 |
| APP | amyloid beta (A4) precursor protein | 0.0290137 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0288676 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0276636 |
| TPM3 | tropomyosin 3 | 0.027129 |
| MKI67 | marker of proliferation Ki-67 | 0.0271074 |
| MYO5B | myosin VB | 0.0267732 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0266165 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.026605 |
| VMP1 | vacuole membrane protein 1 | 0.0265311 |
| ACTN4 | actinin, alpha 4 | 0.0264649 |
| RPL37A | ribosomal protein L37a | 0.0254588 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0252462 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0249444 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0244343 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0239006 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0238569 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0237736 |
| PTEN | phosphatase and tensin homolog | 0.0236508 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | 0.0236109 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0234114 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0233267 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0233237 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0230416 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.023017 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0229829 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0227571 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0226809 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0226179 |
| MKRN1 | makorin ring finger protein 1 | 0.0225929 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0225745 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.022337 |
| CENPF | centromere protein F, 350/400kDa | 0.0222785 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0220914 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0218473 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 0.0218393 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0217547 |
| SNX13 | sorting nexin 13 | 0.0217345 |
| TJP2 | tight junction protein 2 | 0.0216755 |
| IPO7 | importin 7 | 0.0216612 |
| PRPF6 | pre-mRNA processing factor 6 | 0.0214775 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0214626 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0213885 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.021366 |
| PTK2 | protein tyrosine kinase 2 | 0.0212204 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.157165 |
| FTL | ferritin, light polypeptide | -0.145909 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0903022 |
| EGR1 | early growth response 1 | -0.0889058 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0876977 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0783713 |
| GNAS | GNAS complex locus | -0.0779864 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0770051 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0765424 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0744177 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.064285 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0642005 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0628268 |
| MYO1E | myosin IE | -0.0624239 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0621145 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.060598 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0588845 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0561931 |
| INTS6 | integrator complex subunit 6 | -0.0549402 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0548187 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0547237 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0546222 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0543169 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0530395 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0525278 |
| OXSR1 | oxidative stress responsive 1 | -0.0524148 |
| GOLGB1 | golgin B1 | -0.0524051 |
| EHBP1 | EH domain binding protein 1 | -0.0515218 |
| NDRG1 | N-myc downstream regulated 1 | -0.0509828 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0508019 |
| RPL35A | ribosomal protein L35a | -0.0507458 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0506795 |
| FBXO11 | F-box protein 11 | -0.0480079 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.047043 |
| CADPS | Ca++-dependent secretion activator | -0.0464069 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0459085 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0450123 |
| H1-0 | H1.0 linker histone | -0.0449066 |
| MORF4L2 | mortality factor 4 like 2 | -0.0431985 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0424039 |
| TJP1 | tight junction protein 1 | -0.0410186 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0403598 |
| RPS6 | ribosomal protein S6 | -0.0402544 |
| UBAP2 | ubiquitin associated protein 2 | -0.0396165 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0371865 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.036942 |
| CDK13 | cyclin-dependent kinase 13 | -0.0367267 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0365224 |
| VCL | vinculin | -0.0357879 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0354235 |
| FUS | FUS RNA binding protein | -0.0353373 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0351352 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.0342056 |
| NABP1 | nucleic acid binding protein 1 | -0.0337507 |
| CTSD | cathepsin D | -0.0334352 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0333957 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0333886 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0331996 |
| IER3 | immediate early response 3 | -0.0331192 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0329978 |
| HM13 | histocompatibility (minor) 13 | -0.0323206 |
| SQSTM1 | sequestosome 1 | -0.0322206 |
| SETX | senataxin | -0.0316015 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0312672 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0309066 |
| HDLBP | high density lipoprotein binding protein | -0.0306205 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0306127 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0298782 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0296835 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0290514 |
| PGK1 | phosphoglycerate kinase 1 | -0.0290019 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | -0.0287293 |
| RCOR1 | REST corepressor 1 | -0.0284791 |
| NLK | nemo-like kinase | -0.0284593 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0282329 |
| NOP58 | NOP58 ribonucleoprotein | -0.0278665 |
| FAM107B | family with sequence similarity 107, member B | -0.0277193 |
| MX2 | MX dynamin-like GTPase 2 | -0.0276454 |
| RPL28 | ribosomal protein L28 | -0.0273191 |
| EXOC4 | exocyst complex component 4 | -0.0273012 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0269222 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0268232 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0267879 |
| FAM53C | family with sequence similarity 53, member C | -0.0267274 |
| IRS2 | insulin receptor substrate 2 | -0.0267082 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0265338 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0264205 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0262362 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0261336 |
| KRT19 | keratin 19, type I | -0.0261288 |
| SMAD2 | SMAD family member 2 | -0.0261287 |
| TRIM24 | tripartite motif containing 24 | -0.0259274 |
| TFRC | transferrin receptor | -0.0258889 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0258492 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0258464 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0258363 |
| TMSB10 | thymosin beta 10 | -0.0257736 |
| LDHA | lactate dehydrogenase A | -0.0256451 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0255858 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0255425 |
