Ivabradine (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.126952
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0797237
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0755604
EIF4B eukaryotic translation initiation factor 4B 0.0423439
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.039863
KITLG KIT ligand 0.0352571
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0338041
ACTN4 actinin, alpha 4 0.030874
ZNRF3 zinc and ring finger 3 0.0282044
RAD51B RAD51 paralog B 0.027886
DUSP4 dual specificity phosphatase 4 0.0275941
TBC1D5 TBC1 domain family, member 5 0.0269255
MSI2 musashi RNA-binding protein 2 0.0263799
ZBTB7C zinc finger and BTB domain containing 7C 0.0260582
EEF2 eukaryotic translation elongation factor 2 0.0255023
TGFB2 transforming growth factor, beta 2 0.0252741
NIBAN2 niban apoptosis regulator 2 0.0244717
RPL3 ribosomal protein L3 0.0240945
RPL4 ribosomal protein L4 0.0238383
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0235658
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 0.0225686
FTH1 ferritin, heavy polypeptide 1 0.0211175
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0210516
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0208938
EPHA2 EPH receptor A2 0.0201191
GOLGA2 golgin A2 0.0200196
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0199781
MCL1 myeloid cell leukemia 1 0.0197923
PCBP2 poly(rC) binding protein 2 0.0197435
SFPQ splicing factor proline/glutamine-rich 0.0193491
GDF15 growth differentiation factor 15 0.0193185
PHF14 PHD finger protein 14 0.0189111
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0188749
SLC35F5 solute carrier family 35, member F5 0.0188446
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0183439
NFXL1 nuclear transcription factor, X-box binding-like 1 0.0171352
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0167415
SRRM2 serine/arginine repetitive matrix 2 0.0167265
NBAS neuroblastoma amplified sequence 0.0166598
CCSER1 coiled-coil serine-rich protein 1 0.0166243
ESRP1 epithelial splicing regulatory protein 1 0.0160937
HYOU1 hypoxia up-regulated 1 0.0160808
GIGYF2 GRB10 interacting GYF protein 2 0.0160383
EIF4A1 eukaryotic translation initiation factor 4A1 0.0159852
NGLY1 N-glycanase 1 0.0157336
ANXA11 annexin A11 0.0156143
FAR1 fatty acyl CoA reductase 1 0.0153289
EDAR ectodysplasin A receptor 0.0152353
ANKRD36 ankyrin repeat domain 36 0.0152188
SNX13 sorting nexin 13 0.0152184
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0151561
KLF3 Kruppel-like factor 3 (basic) 0.0151207
CD46 CD46 molecule, complement regulatory protein 0.0149246
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0149074
FHIT fragile histidine triad 0.0148519
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0147135
ICA1 islet cell autoantigen 1, 69kDa 0.0147119
TBCD tubulin folding cofactor D 0.0144911
IGSF9B immunoglobulin superfamily, member 9B 0.0143678
KIF16B kinesin family member 16B 0.0143636
AGPS alkylglycerone phosphate synthase 0.0143473
ITGB4 integrin, beta 4 0.0143052
UCK2 uridine-cytidine kinase 2 0.0139182
FOXP1 forkhead box P1 0.0138547
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0138518
PTEN phosphatase and tensin homolog 0.0138068
FMNL2 formin-like 2 0.0137824
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.0137016
MAT2A methionine adenosyltransferase II, alpha 0.0136727
RNF43 ring finger protein 43 0.0136147
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0135602
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0134781
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0133036
FAM135A family with sequence similarity 135, member A 0.0132952
PAWR PRKC, apoptosis, WT1, regulator 0.0131321
NFE2L1 nuclear factor, erythroid 2-like 1 0.0130909
RBM26 RNA binding motif protein 26 0.0129707
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0128109
TUT4 terminal uridylyl transferase 4 0.0128104
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.012698
ELP2 elongator acetyltransferase complex subunit 2 0.0126851
PDE4D phosphodiesterase 4D, cAMP-specific 0.0126336
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0124749
CDYL chromodomain protein, Y-like 0.0123624
MDN1 MDN1, midasin homolog (yeast) 0.0123601
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0122574
FMN1 formin 1 0.0122546
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 0.0121466
SREBF1 sterol regulatory element binding transcription factor 1 0.0120168
EPN2 epsin 2 0.0119636
FAT1 FAT atypical cadherin 1 0.0119286
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0118838
SRSF1 serine/arginine-rich splicing factor 1 0.0118514
BCL2L1 BCL2-like 1 0.0117778
RARS1 arginyl-tRNA synthetase 1 0.0116921
TBRG4 transforming growth factor beta regulator 4 0.0116607
PDE10A phosphodiesterase 10A 0.0115927
KANSL3 KAT8 regulatory NSL complex subunit 3 0.0113904
CTNND1 catenin (cadherin-associated protein), delta 1 0.0113086
TCOF1 Treacher Collins-Franceschetti syndrome 1 0.0112796

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.246156
RPS6 ribosomal protein S6 -0.17995
IER3 immediate early response 3 -0.176419
AREG amphiregulin -0.154699
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.140654
TPT1 tumor protein, translationally-controlled 1 -0.131565
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.130219
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.122262
TMSB10 thymosin beta 10 -0.0998081
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0991199
EGR1 early growth response 1 -0.0960241
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0878885
EGFR epidermal growth factor receptor -0.082521
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0823589
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0778892
RPS8 ribosomal protein S8 -0.0746118
RPS2 ribosomal protein S2 -0.0740838
ACTG1 actin gamma 1 -0.0733932
PLAUR plasminogen activator, urokinase receptor -0.0714003
RPS24 ribosomal protein S24 -0.0680402
TSC22D2 TSC22 domain family, member 2 -0.066138
RPL32 ribosomal protein L32 -0.0641266
HMGA1 high mobility group AT-hook 1 -0.0627751
SNX9 sorting nexin 9 -0.062718
LMO7 LIM domain 7 -0.0619353
RPLP1 ribosomal protein, large, P1 -0.0616026
RPL34 ribosomal protein L34 -0.0609022
RPL35A ribosomal protein L35a -0.0602807
LAMA4 laminin, alpha 4 -0.0594848
S100A10 S100 calcium binding protein A10 -0.0593235
ITPKC inositol-trisphosphate 3-kinase C -0.0591913
ANXA1 annexin A1 -0.057376
RPLP2 ribosomal protein, large, P2 -0.0564145
HSPA8 heat shock 70kDa protein 8 -0.0555159
RPLP0 ribosomal protein, large, P0 -0.0549459
LDHA lactate dehydrogenase A -0.0534892
UBC ubiquitin C -0.0533108
LAMC2 laminin, gamma 2 -0.0531899
ATXN1 ataxin 1 -0.0514988
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0506969
ANXA2 annexin A2 -0.049523
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0489708
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0488121
EMP1 epithelial membrane protein 1 -0.0480422
RPL26 ribosomal protein L26 -0.0480254
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0478153
RPS5 ribosomal protein S5 -0.0471743
RPL11 ribosomal protein L11 -0.0464441
SETD5 SET domain containing 5 -0.0463059
RPL5 ribosomal protein L5 -0.0462992
RPL12 ribosomal protein L12 -0.0451212
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0447688
RPS25 ribosomal protein S25 -0.044438
LOC112694756 uncharaterized LOC112694756 -0.0437895
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0437729
PTMA prothymosin, alpha -0.0429279
RPL31 ribosomal protein L31 -0.0426343
ZFAND3 zinc finger, AN1-type domain 3 -0.042628
RPS13 ribosomal protein S13 -0.0420204
EIF1 eukaryotic translation initiation factor 1 -0.0416518
RPL8 ribosomal protein L8 -0.041542
ATP5F1B ATP synthase F1 subunit beta -0.041534
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0413239
RPL9 ribosomal protein L9 -0.0405031
FHL2 four and a half LIM domains 2 -0.0400473
NUP50 nucleoporin 50kDa -0.0398721
RPL7 ribosomal protein L7 -0.0396716
RPS29 ribosomal protein S29 -0.0393795
RPL19 ribosomal protein L19 -0.0391361
BIRC3 baculoviral IAP repeat containing 3 -0.0389533
RBM39 RNA binding motif protein 39 -0.0385552
GOLGA4 golgin A4 -0.038439
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0382972
RPS19 ribosomal protein S19 -0.0378165
RAB1A RAB1A, member RAS oncogene family -0.0377792
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0370618
YAP1 Yes-associated protein 1 -0.0369452
RLF rearranged L-myc fusion -0.0366925
RPL38 ribosomal protein L38 -0.0365322
CLTC clathrin, heavy chain (Hc) -0.03647
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0364625
RPS15 ribosomal protein S15 -0.0364288
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0362501
NDRG1 N-myc downstream regulated 1 -0.0360773
RPS23 ribosomal protein S23 -0.0358588
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0353383
SEPTIN7 septin 7 -0.0344219
PUM2 pumilio RNA-binding family member 2 -0.0344173
HMGA2 high mobility group AT-hook 2 -0.033955
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0338789
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0335092
UGDH UDP-glucose 6-dehydrogenase -0.0334129
RSL1D1 ribosomal L1 domain containing 1 -0.0333371
TPM4 tropomyosin 4 -0.0332976
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.033209
KMT2E lysine (K)-specific methyltransferase 2E -0.0330803
CSNK1A1 casein kinase 1, alpha 1 -0.0329318
KLF6 Kruppel-like factor 6 -0.0325023
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0322097
RPS27A ribosomal protein S27a -0.0319964