Ivabradine (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ivabradine (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ivabradine (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.0921097
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0828824
EEF2 eukaryotic translation elongation factor 2 0.0819051
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0805226
ENO1 enolase 1, (alpha) 0.0730997
ESYT2 extended synaptotagmin-like protein 2 0.0703858
PDGFA platelet-derived growth factor alpha polypeptide 0.0679339
RPS12 ribosomal protein S12 0.0670966
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0625353
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0598673
TMSB10 thymosin beta 10 0.0589713
OGA O-GlcNAcase 0.0586128
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0575287
ZNF292 zinc finger protein 292 0.0547721
EIF1 eukaryotic translation initiation factor 1 0.050153
GOLGA4 golgin A4 0.0493757
OXR1 oxidation resistance 1 0.0478482
RPL37A ribosomal protein L37a 0.0471916
RPS6 ribosomal protein S6 0.0470991
RPLP1 ribosomal protein, large, P1 0.0469985
PCBP2 poly(rC) binding protein 2 0.0463821
RPS8 ribosomal protein S8 0.045872
ERRFI1 ERBB receptor feedback inhibitor 1 0.0449839
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0445778
RPL23 ribosomal protein L23 0.0434329
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0432811
RPL26 ribosomal protein L26 0.0431156
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0428503
CD46 CD46 molecule, complement regulatory protein 0.0412316
AKAP9 A kinase (PRKA) anchor protein 9 0.0408404
RPL12 ribosomal protein L12 0.0391588
ABHD2 abhydrolase domain containing 2 0.0390575
MORF4L2 mortality factor 4 like 2 0.0389332
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.038765
KMT2E lysine (K)-specific methyltransferase 2E 0.0380675
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0376386
TXNIP thioredoxin interacting protein 0.0375318
DDIT4 DNA-damage-inducible transcript 4 0.0373084
RPL4 ribosomal protein L4 0.0371673
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0369317
UBA6 ubiquitin-like modifier activating enzyme 6 0.0369299
CEMIP2 cell migration inducing hyaluronidase 2 0.0361616
ITGA6 integrin, alpha 6 0.0356111
KPNB1 karyopherin (importin) beta 1 0.0351282
RACK1 receptor for activated C kinase 1 0.035035
GARS1 glycyl-tRNA synthetase 1 0.0348446
KMT2C lysine (K)-specific methyltransferase 2C 0.0344889
RPS19 ribosomal protein S19 0.0343048
EIF4B eukaryotic translation initiation factor 4B 0.0341746
RPL7 ribosomal protein L7 0.0332142
SNX9 sorting nexin 9 0.0331131
VIM vimentin 0.0331009
BHLHE40 basic helix-loop-helix family, member e40 0.0330579
RPS27A ribosomal protein S27a 0.032937
RPL5 ribosomal protein L5 0.0328028
MYH9 myosin, heavy chain 9, non-muscle 0.0319467
RPS2 ribosomal protein S2 0.0317719
YEATS2 YEATS domain containing 2 0.0315904
SET SET nuclear proto-oncogene 0.0309003
RPL18 ribosomal protein L18 0.0308992
RPL3 ribosomal protein L3 0.0308959
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0308487
PRRC2C proline-rich coiled-coil 2C 0.0307273
PTMA prothymosin, alpha 0.0307228
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0304163
ETNK1 ethanolamine kinase 1 0.030408
LOC112694756 uncharaterized LOC112694756 0.0301058
RPL11 ribosomal protein L11 0.0301041
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0300671
CTNND1 catenin (cadherin-associated protein), delta 1 0.0298382
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0297694
CCDC82 coiled-coil domain containing 82 0.0297524
RPS17 ribosomal protein S17 0.0297476
BIRC6 baculoviral IAP repeat containing 6 0.0295776
BRWD3 bromodomain and WD repeat domain containing 3 0.0292675
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0292126
PGK1 phosphoglycerate kinase 1 0.0291681
TMEM41B transmembrane protein 41B 0.0290027
RBM39 RNA binding motif protein 39 0.0288166
AFDN afadin, adherens junction formation factor 0.0285731
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0284179
PDE8A phosphodiesterase 8A 0.0283366
EIF4A1 eukaryotic translation initiation factor 4A1 0.0283129
PERP PERP, TP53 apoptosis effector 0.0281808
NIPSNAP2 nipsnap homolog 2 0.028101
SRP54 signal recognition particle 54kDa 0.0280191
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.027795
RPL19 ribosomal protein L19 0.0275677
SETD5 SET domain containing 5 0.0275467
RPS4X ribosomal protein S4, X-linked 0.027416
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0273942
DSPP dentin sialophosphoprotein 0.026908
AHNAK AHNAK nucleoprotein 0.0267645
AVL9 AVL9 homolog (S. cerevisiase) 0.0266119
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0264979
RPL37 ribosomal protein L37 0.0263438
PCM1 pericentriolar material 1 0.0262324
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0258733
EXOC1 exocyst complex component 1 0.0257841
RNF149 ring finger protein 149 0.0257521

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.202508
NAV2 neuron navigator 2 -0.132319
INTS6 integrator complex subunit 6 -0.125412
VCL vinculin -0.114968
CDH13 cadherin 13 -0.107827
SDK1 sidekick cell adhesion molecule 1 -0.100546
ASPH aspartate beta-hydroxylase -0.0801759
CCND1 cyclin D1 -0.0738004
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0681178
SLC38A2 solute carrier family 38, member 2 -0.0665311
ADGRL2 adhesion G protein-coupled receptor L2 -0.0663866
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0659368
WWOX WW domain containing oxidoreductase -0.0641431
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0612506
ANO1 anoctamin 1, calcium activated chloride channel -0.0606028
RAD51B RAD51 paralog B -0.0605073
PDE4D phosphodiesterase 4D, cAMP-specific -0.059112
GMDS GDP-mannose 4,6-dehydratase -0.0567206
EXOC4 exocyst complex component 4 -0.0564687
MRPS6 mitochondrial ribosomal protein S6 -0.0478098
CDK6 cyclin-dependent kinase 6 -0.047119
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0451976
SKAP1 src kinase associated phosphoprotein 1 -0.044614
NPAS2 neuronal PAS domain protein 2 -0.0433059
UBAP2 ubiquitin associated protein 2 -0.0430906
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0399896
FRMD5 FERM domain containing 5 -0.0386531
FHIT fragile histidine triad -0.0382486
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0368084
MAML2 mastermind-like 2 (Drosophila) -0.03569
TAS2R14 taste receptor, type 2, member 14 -0.0356211
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0355714
ZBTB20 zinc finger and BTB domain containing 20 -0.0343858
PDLIM5 PDZ and LIM domain 5 -0.0341585
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0330819
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.033011
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0329692
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0324194
LRMDA leucine rich melanocyte differentiation associated -0.0321791
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.031356
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0312777
LPP LIM domain containing preferred translocation partner in lipoma -0.0312075
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0306052
SYT1 synaptotagmin I -0.0305641
DIAPH2 diaphanous-related formin 2 -0.0300787
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0291942
PCDH9 protocadherin 9 -0.0281493
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0275668
NABP1 nucleic acid binding protein 1 -0.0269216
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.026876
BACE2 beta-site APP-cleaving enzyme 2 -0.0267661
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0267617
CD44 CD44 molecule (Indian blood group) -0.0267019
RABGAP1L RAB GTPase activating protein 1-like -0.0264901
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0257181
COBL cordon-bleu WH2 repeat protein -0.025648
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0254147
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0253296
MTAP methylthioadenosine phosphorylase -0.0249318
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0249019
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0248681
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0245902
RCOR1 REST corepressor 1 -0.0244466
DOCK9 dedicator of cytokinesis 9 -0.0241966
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0241602
CUX1 cut-like homeobox 1 -0.0239592
PTPRK protein tyrosine phosphatase, receptor type, K -0.023885
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0238325
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0235383
FUS FUS RNA binding protein -0.0230516
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.022795
CDK13 cyclin-dependent kinase 13 -0.022724
TTC17 tetratricopeptide repeat domain 17 -0.0227153
EHBP1 EH domain binding protein 1 -0.0226053
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.0222014
COMMD10 COMM domain containing 10 -0.0220389
TFRC transferrin receptor -0.0217236
NTSR1 neurotensin receptor 1 (high affinity) -0.0216923
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.021592
MYOF myoferlin -0.0215202
RAB7A RAB7A, member RAS oncogene family -0.0214772
TNIK TRAF2 and NCK interacting kinase -0.0214213
PUM3 pumilio RNA binding family member 3 -0.0213272
ARHGAP26 Rho GTPase activating protein 26 -0.0211179
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.02111
PRH1 proline-rich protein HaeIII subfamily 1 -0.0209802
NCEH1 neutral cholesterol ester hydrolase 1 -0.0209749
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0209273
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.020926
DNAH14 dynein, axonemal, heavy chain 14 -0.0208543
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0206157
AIG1 androgen-induced 1 -0.0205493
AEBP2 AE binding protein 2 -0.0205181
PRKCA protein kinase C, alpha -0.020268
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0202571
ANXA3 annexin A3 -0.0202458
IGF2 insulin-like growth factor 2 -0.0202294
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0202045
ANKRD17 ankyrin repeat domain 17 -0.0201933
GPHN gephyrin -0.0201719